Search Results - "Burrowes, K. S."

Sex matters: the frequently overlooked importance of considering sex in computational models by Burrowes, K S, Ruppage, M, Lowry, A, Zhao, D

“…Personalised medicine and the development of a virtual human or a digital twin comprises visions of the future of medicine. To realise these innovations, an…”
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Vaping causes an acute BMI‐dependent change in pulmonary blood flow by Burrowes, K. S., Seal, M., Noorababaee, L., Pontré, B., Dubowitz, D., Sá, R. C., Prisk, G. K.

“…Vaping use has skyrocketed especially among young adults, however there is no consensus on how vaping impacts the lungs. We aimed to determine whether there…”
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The interdependent contributions of gravitational and structural features to perfusion distribution in a multiscale model of the pulmonary circulation by CLARK, A. R, TAWHAI, M. H, HOFFMAN, E. A, BURROWES, K. S

“…Recent experimental and imaging studies suggest that the influence of gravity on the measured distribution of blood flow in the lung is largely through…”
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Assessing potential errors of MRI-based measurements of pulmonary blood flow using a detailed network flow model by BURROWES, K. S, BUXTON, R. B, PRISK, G. K

“…MRI images of pulmonary blood flow using arterial spin labeling (ASL) measure the delivery of magnetically tagged blood to an image plane during one systolic…”
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Contribution of serial and parallel microperfusion to spatial variability in pulmonary inter- and intra-acinar blood flow by CLARK, A. R, BURROWES, K. S, TAWHAI, M. H

“…This study presents a theoretical model of combined series and parallel perfusion in the human pulmonary acinus that maintains computational simplicity while…”
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Hypoxic Pulmonary Vasoconstriction as a Contributor to Response in Acute Pulmonary Embolism by Burrowes, K. S., Clark, A. R., Wilsher, M. L., Milne, D. G., Tawhai, M. H.

“…Hypoxic pulmonary vasoconstriction (HPV) is an adaptive response unique to the lung whereby blood flow is diverted away from areas of low alveolar oxygen to…”
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Pulmonary embolism: predicting disease severity by Burrowes, K. S., Clark, A. R., Mrcinkowski, A., Wilsher, M. L., Mlne, D. G., Tawhai, M. H.

“…Pulmonary embolism (PE) is the most common cause of acute pulmonary hypertension, yet it is commonly undiagnosed, with risk of death if not recognized promptly…”
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Species-Specific Pulmonary Arterial Asymmetry Determines Species Differences in Regional Pulmonary Perfusion by Burrowes, K. S, Hoffman, E. A, Tawhai, M. H

“…The functional significance of differences in pulmonary vascular branching and diameter asymmetry between the human and quadruped lung has not previously been…”
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Multi-scale computational models of the airways to unravel the pathophysiological mechanisms in asthma and chronic obstructive pulmonary disease (AirPROM) by Burrowes, K. S., De Backer, J., Smallwood, R., Sterk, P. J., Gut, I., Wirix-Speetjens, R., Siddiqui, S., Owers-Bradley, J., Wild, J., Maier, D., Brightling, C.

“…The respiratory system comprises several scales of biological complexity: the genes, cells and tissues that work in concert to generate resultant function…”
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A viscoelastic two-dimensional network model of the lung extracellular matrix by Iravani, A., Thambyah, A., Burrowes, K. S.

“…The extracellular matrix (ECM) comprises a large proportion of the lung parenchymal tissue and is an important contributor to the mechanical properties of the…”
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The impact of micro-embolism size on haemodynamic changes in the pulmonary micro-circulation by Clark, A.R, Burrowes, K.S, Tawhai, M.H

“…Abstract Embolus occlusion of pulmonary arteries can result in elevated pulmonary blood pressures, often resulting in pulmonary hypertension (PH). Experimental…”
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An in silico approach to understanding the interaction between cardiovascular and pulmonary lymphatic dysfunction by Ashworth, E T, Burrowes, K S, Clark, A R, Ebrahimi, B S Shaarbaf, Tawhai, M H

“…The lung is extremely sensitive to interstitial fluid balance, yet the role of pulmonary lymphatics in lung fluid homeostasis and its interaction with…”
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In Silico Ventilation Within the Dose-Volume is Predictive of Lung Function Post-radiation Therapy in Patients with Lung Cancer by Dong, Yu, Kumar, H., Tawhai, M., Veiga, C., Szmul, A., Landau, D., McClelland, J., Lao, L., Burrowes, K. S.

“…Lung cancer is a leading cause of death worldwide. Radiation therapy (RT) is one method to treat this disease. A common side effect of RT for lung cancer is…”
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ECAM: A low-cost vaping device for generating and collecting electronic cigarette condensate for in vitro studies by Campbell, R.T., Suresh, V., Burrowes, K.S.

“…[Display omitted] The use of electronic cigarettes (ECs) has become widespread despite many unknowns around their long-term health impact. ECs work by…”
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Towards a virtual lung: multi-scale, multi-physics modelling of the pulmonary system by Burrowes, K.S, Swan, A.J, Warren, N.J, Tawhai, M.H

“…The essential function of the lung, gas exchange, is dependent on adequate matching of ventilation and perfusion, where air and blood are delivered through…”
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Lack of functional information explains the poor performance of ‘clot load scores’ at predicting outcome in acute pulmonary embolism by Clark, A.R, Milne, D, Wilsher, M, Burrowes, K.S, Bajaj, M, Tawhai, M.H

“…Highlights • We model the response of individuals to pulmonary embolism including the spatial distribution of emboli. • Model predictions correlate well with…”
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Coupling of lung tissue tethering force to fluid dynamics in the pulmonary circulation by Burrowes, K. S., Tawhai, M. H.

“…Dynamic changes in lung volume during breathing and alteration of posture are both known to influence the distribution of perfusion within the lung. Here we…”
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Computational modeling of airway and pulmonary vascular structure and function: development of a "lung physiome" by Tawhai, Merryn, Clark, A, Donovan, G, Burrowes, K

“…Computational models of lung structure and function necessarily span multiple spatial and temporal scales, i.e., dynamic molecular interactions give rise to…”
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Blood flow redistribution and ventilation-perfusion mismatch during embolic pulmonary arterial occlusion by Burrowes, K. S., Clark, A. R., Tawhai, M. H.

“…Acute pulmonary embolism causes redistribution of blood in the lung, which impairs ventilation/perfusion matching and gas exchange and can elevate pulmonary…”
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Modeling RBC and neutrophil distribution through an anatomically based pulmonary capillary network by Burrowes, Kelly S, Tawhai, Merryn H, Hunter, Peter J

“…An anatomically based finite element model of the human pulmonary microcirculation has been created and applied to simulating regional variations in blood…”
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