Search Results - "Burra, Sirisha"

Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels by Batra, Nidhi, Burra, Sirisha, Siller-Jackson, Arlene J, Gu, Sumin, Xia, Xuechun, Weber, Gregory F, DeSimone, Douglas, Bonewald, Lynda F, Lafer, Eileen M, Sprague, Eugene, Schwartz, Martin A, Jiang, Jean X

“…The connexin 43 (Cx43) hemichannel (HC) in the mechanosensory osteocytes is a major portal for the release of factors responsible for the anabolic effects of…”
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Direct Regulation of Osteocytic Connexin 43 Hemichannels through AKT Kinase Activated by Mechanical Stimulation by Batra, Nidhi, Riquelme, Manuel A., Burra, Sirisha, Kar, Rekha, Gu, Sumin, Jiang, Jean X.

“…Connexin (Cx) 43 hemichannels in osteocytes are thought to play a critical role in releasing bone modulators in response to mechanical loading, a process…”
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Connexin 43 Channels Are Essential for Normal Bone Structure and Osteocyte Viability by Xu, Huiyun, Gu, Sumin, Riquelme, Manuel A, Burra, Sirisha, Callaway, Danielle, Cheng, Hongyun, Guda, Teja, Schmitz, James, Fajardo, Roberto J, Werner, Sherry L, Zhao, Hong, Shang, Peng, Johnson, Mark L, Bonewald, Lynda F, Jiang, Jean X

“…ABSTRACT Connexin (Cx) 43 serves important roles in bone function and development. Targeted deletion of Cx43 in osteoblasts or osteocytes leads to increased…”
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Dendritic processes of osteocytes are mechanotransducers that induce the opening of hemichannels by Burra, Sirisha, Nicolella, Daniel P., Francis, W. Loren, Freitas, Christopher J., Mueschke, Nicholas J., Poole, Kristin, Jiang, Jean X., Weinbaum, Sheldon

“…Osteocytes with long dendritic processes are known to sense mechanical loading, which is essential for bone remodeling. There has been a long-standing debate…”
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14-3-3θ facilitates plasma membrane delivery and function of mechanosensitive connexin 43 hemichannels by Batra, Nidhi, Riquelme, Manuel A, Burra, Sirisha, Jiang, Jean X

“…Intracellular signaling in osteocytes activated by mechanical loading is important for bone formation and remodeling. These signaling events are mediated by…”
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Adaptation of Connexin 43-Hemichannel Prostaglandin Release to Mechanical Loading by Siller-Jackson, Arlene J., Burra, Sirisha, Gu, Sumin, Xia, Xuechun, Bonewald, Lynda F., Sprague, Eugene, Jiang, Jean X.

“…Bone tissues respond to mechanical loading/unloading regimens to accommodate (re)modeling requirements; however, the underlying molecular mechanism responsible…”
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Pvr and distinct downstream signaling factors are required for hemocyte spreading and epidermal wound closure at Drosophila larval wound sites by Tsai, Chang-Ru, Wang, Yan, Jacobson, Alec, Sankoorikkal, Niki, Chirinos, Josue D, Burra, Sirisha, Makthal, Nishanth, Kumaraswami, Muthiah, Galko, Michael J

“…Tissue injury is typically accompanied by inflammation. In Drosophila melanogaster larvae, wound-induced inflammation involves adhesive capture of hemocytes at…”
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Connexin 43 hemichannel opening associated with Prostaglandin E2 release is adaptively regulated by mechanical stimulation by Burra, Sirisha, Jiang, Jean X.

“…Osteocytes present in the bone are known to be the major mechanosensory cells. Their involvement in mechanoregulation of bone remodeling is not yet clear…”
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Dark horse in osteocyte biology: Glycocalyx around the dendrites is critical for osteocyte mechanosensing by Burra, Sirisha, Nicolella, Daniel P, Jiang, Jean X

“…Osteocytes are considered as the major mechanosensory cells of the bone tissue that control the bone remodeling process. Since osteocytes are buried inside…”
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Drosophila larval epidermal cells only exhibit epidermal aging when they persist to the adult stage by Wang, Yan, Burra, Sirisha, Galko, Michael J

“…Holometabolous insects undergo a complete transformation of the body plan from the larval to the adult stage. In , this transformation includes replacement of…”
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Mitogen-activated Protein Kinase (MAPK) Activated by Prostaglandin E2 Phosphorylates Connexin 43 and Closes Osteocytic Hemichannels in Response to Continuous Flow Shear Stress by Riquelme, Manuel A., Burra, Sirisha, Kar, Rekha, Lampe, Paul D., Jiang, Jean X.

“…Cx43 hemichannels serve as a portal for the release of prostaglandins, a critical process in mediating biological responses of mechanical loading on bone…”
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Roles of gap junctions and hemichannels in bone cell functions and in signal transmission of mechanical stress by Jiang, Jean Xin, Siller-Jackson, Arlene Janel, Burra, Sirisha

“…Gap junctions formed by connexins (Cx) play an important role in transmitting signals between bone cells such as osteoblasts and osteoclasts, cells responsible…”
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Yorkie regulates epidermal wound healing in Drosophila larvae independently of cell proliferation and apoptosis by Tsai, Chang-Ru, Anderson, Aimee E., Burra, Sirisha, Jo, Juyeon, Galko, Michael J.

“…Yorkie (Yki), the transcriptional co-activator of the Hippo signaling pathway, has well-characterized roles in balancing apoptosis and cell division during…”
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Regulation of cellular function by connexin hemichannels by Burra, Sirisha, Jiang, Jean X

“…Gap junctions and hemichannels are formed by a family of proteins called connexins. Till date up to twenty one different connexins have been characterized and…”
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Using Drosophila larvae to study epidermal wound closure and inflammation by Burra, Sirisha, Wang, Yan, Brock, Amanda R, Galko, Michael J

“…This methods chapter describes two methods for creating epithelial wounds in Drosophila larvae: pinch and puncture wounding. It also covers protocols for…”
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Connexin 43 hemichannel opening associated with Prostaglandin E 2 release is adaptively regulated by mechanical stimulation by Burra, Sirisha, Jiang, Jean X.

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Mechanical stress-activated integrin [alpha]5[Beta]1 induces opening of connexin 43 hemichannels by Batra, Nidhi, Burra, Sirisha, Siller-Jackson, Arlene J, Gu, Sumin, Xia, Xuechun, Weber, Gregory F, DeSimone, Douglas, Bonewald, Lynda F, Lafer, Eileen M, Sprague, Eugene, Schwartz, Martin A, Jiang, Jean X

“…The connexin 43 (Cx43) hemichannel (HC) in the mechanosensory osteocytes is a major portal for the release of factors responsible for the anabolic effects of…”
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Dark horse in osteocyte biology: Glycocalyx around the dendrites is critical for osteocyte mechanosensing by Burra, Sirisha, Nicolella, Daniel P., Jiang, Jean X.

“…Osteocytes are considered as the major mechanosensory cells of the bone tissue that control the bone remodeling process. Since osteocytes are buried inside…”
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Connexin 43 hemichannel opening associated with Prostaglandin E(2) release is adaptively regulated by mechanical stimulation by Burra, Sirisha, Jiang, Jean X

“…Osteocytes present in the bone are known to be the major mechanosensory cells. Their involvement in mechanoregulation of bone remodeling is not yet clear…”
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Regulation of connexin 43 hemichannels by mechanical loading, integrins and activated kinases in bone osteocytes by Burra, Sirisha

“…Osteocytes are the known mechanosensory cells in bone and are characterized by long dendritic processes. Mechanical signals travel from one osteocyte to…”
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