Search Results - "Burra, Prasad V. L. S."

RNA Dependent RNA Polymerases: Insights from Structure, Function and Evolution by Venkataraman, Sangita, Prasad, Burra V L S, Selvarajan, Ramasamy

“…RNA dependent RNA polymerase (RdRp) is one of the most versatile enzymes of RNA viruses that is indispensable for replicating the genome as well as for…”
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Conformational variation of site specific glycated albumin: A Molecular dynamics approach by Jeevanandam, Jayanth, Burra, V. L. S. Prasad, Saraswathi, N.T.

“…Human serum albumin (HSA) is a major cargo protein, which undergoes glycation in hyperglycaemic conditions and results in impaired function. In physiological…”
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An in silico approach to study the role of epitope order in the multi-epitope-based peptide (MEBP) vaccine design by Salaikumaran, Muthu Raj, Kasamuthu, Prasanna Sudharson, Aathmanathan, Veeranarayanan Surya, Burra, V. L. S. Prasad

“…With different countries facing multiple waves, with some SARS-CoV-2 variants more deadly and virulent, the COVID-19 pandemic is becoming more dangerous by the…”
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Designing a next generation multi-epitope based peptide vaccine candidate against SARS-CoV-2 using computational approaches by Saha, Ratnadeep, Ghosh, Pratik, Burra, V. L. S. Prasad

“…COVID-19 caused by SARS-CoV-2 was declared a global pandemic by WHO (World Health Organization) in March, 2020. Within 6 months, nearly 750,000 deaths are…”
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16S rRNA Methyltransferases as Novel Drug Targets Against Tuberculosis by Salaikumaran, M. R., Badiger, Veena P., Burra, V. L. S. Prasad

“…Tuberculosis (TB) is an airborne infectious disease caused by Mycobacterium tuberculosis ( M.tb ) whose natural history traces back to 70,000 years. TB remains…”
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Molecular docking analysis reveals differential binding affinities of multiple classes of selective inhibitors towards cancer-associated KRAS mutants by Mullaguri, Sai Charitha, Akula, Sravani, Sahoo, Partha Sarathi, Ashireddygari, Vigneshwar Reddy, Mupparapu, Vyshnavika, Silveri, Ravalika, Prasad Burra, V. L. S., Kancha, Rama Krishna

“…KRAS is the most frequently mutated oncogene in solid cancers, and inhibitors that specifically target the KRAS-G12C mutant were recently approved for clinical…”
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Appraisal of Pancreatic Lipase Inhibitory Potential of Ziziphus oenoplia (L.)Mill. Leaves by In Vitro and In Silico Approaches by Vulichi, Srinivasa R., Runthala, Ashish, Rachamreddy, Siva K., Yaramanedi, Radhika S. P., Sahoo, Partha Sarathi, Burra, Prasad V. L. S., Kaur, Nameet, Akkiraju, Sudheer, Kanala, Somasekhar Reddy, Chippada, Appa Rao, Murthy, Sistla Durga Srinivasa

“…Pancreatic lipase is one of the crucial lipolytic enzymes of the gut that actively facilitates the digestion and absorption of the dietary triglycerides and…”
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S-adenosyl-l-methionine interaction signatures in methyltransferases by Kadam, Mangal S., Burra, V. L. S. Prasad

“…The switching on or off of methylation, a change from a normal methylation to hyper or hypo methylation is implicated in many diseases that include cancers,…”
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Estimated sensitivity profiles of lung cancer specific uncommon BRAF mutants towards experimental and clinically approved kinase inhibitors by Mullaguri, Sai Charitha, Akula, Sravani, Ashireddygari, Vigneshwar Reddy, Sahoo, Partha Sarathi, Burra, V.L.S. Prasad, Silveri, Ravalika, Mupparapu, Vyshnavika, Korikani, Meghana, Amanchi, Nageswara Rao, Subramanian, Janakiraman, Kancha, Rama Krishna

“…Current experimental and clinical data are inadequate to conclusively predict the oncogenicity of uncommon BRAF mutants and their sensitivity towards kinase…”
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Computational and Synthetic approach with Biological Evaluation of Substituted Quinoline derivatives as small molecule L858R/T790M/C797S triple mutant EGFR inhibitors targeting resistance in Non-Small Cell Lung Cancer (NSCLC) by Karnik, Kshipra S., Sarkate, Aniket P., Tiwari, Shailee V., Azad, Rajaram, Burra, Prasad V.L.S., Wakte, Pravin S.

“…[Display omitted] •Novel substituted quinoline derivatives were designed and synthesized serving as new L858R/T790M/C797S triple mutant EGFR-TKIs.•Among the…”
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Ultrasound assisted synthesis of tetrazole based pyrazolines and isoxazolines as potent anticancer agents via inhibition of tubulin polymerization by Dofe, Vidya S., Sarkate, Aniket P., Tiwari, Shailee V., Lokwani, Deepak K., Karnik, Kshipra S., Kale, Ishwari A., Dodamani, Suneel, Jalalpure, Sunil S., Burra, Prasad V.L.S.

“…[Display omitted] •Ultrasound assisted method was employed for the synthesis of tetrazole based pyrazolines and isoxazolines derivatives.•Two synthesized…”
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Understanding the structural basis of the binding specificity of c-di-AMP to M. smegmatis RecA using computational biology approach by Burra, V. L. S. Prasad, Sahoo, Partha Sarathi, Dhankhar, Amit, Jhajj, Jatinder, Kasamuthu, Prasanna Sudharson, K, S. S. V. Kiran, Macha, Samuel Krupa Rakshan

“…Mycobacterium tuberculosis RecA (MtRecA), a protein involved in DNA repair, homologous recombination and SOS pathway, contributes to the development of…”
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Efficient Synthesis of Densely Functionalized Pyrido[2,3-d]Pyrimidines via Three-component One-pot Domino Knoevenagel aza-Diels Alder Reaction and Induces Apoptosis in Human Cancer Cell Lines via Inhibiting Aurora A and B Kinases by Bhosle, Manisha R., Palke, Amruta, Bondle, Giribala M., Sarkate, Aniket P., Azad, Rajaram, Burra, Prasad V. L. S.

“…The identification of novel aurora kinase inhibitors is one of the most attractive directions in the field of anticancer research and development. In our…”
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One pot synthesis, in silico study and evaluation of some novel flavonoids as potent topoisomerase II inhibitors by Sarkate, Aniket P., Dofe, Vidya S., Tiwari, Shailee V., Lokwani, Deepak K., Karnik, Kshipra S., Kamble, Darshana D., Ansari, Mujahed H.S.H., Dodamani, Suneel, Jalalpure, Sunil S., Sangshetti, Jaiprakash N., Azad, Rajaram, Burra, Prasad V.L.S., Bhandari, Shashikant V.

“…[Display omitted] •One pot method was employed for the synthesis of novel flavonoid derivatives.•Seven synthesized compounds demonstrated an antiproliferative…”
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Development of triple mutant T790M/C797S allosteric EGFR inhibitors: a computational approach by Karnik, Kshipra S., Sarkate, Aniket P., Lokwani, Deepak K., Narula, Ishudeep S., Burra, Prasad V. L. S., Wakte, Pravin S.

“…The mutations concerned with non-small cell lung cancer involving epidermal growth factor receptor of tyrosine kinase family have primarily targeted. EGFR…”
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Rapid Serological Testing for Managing the COVID-19 Pandemic: A Review by Faheem, Sultan M., D’Mello, Jancie, Kaleem, Sultan M., Prasad, Burra V. L. S., Siddiqui, Khalid

“…With the onset of the novel coronavirus disease pandemic (COVID-19) that emerged from Wuhan in China, the need of the hour can be summarized into two groups…”
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Design and synthesis of novel conformationally constrained 7,12-dihydrodibenzo[b,h][1,6] naphthyridine and 7H-Chromeno[3,2-c] quinoline derivatives as topoisomerase I inhibitors: In vitro screening, molecular docking and ADME predictions by Kardile, Ramakant A., Sarkate, Aniket P., Borude, Avinash S., Mane, Rajendra S., Lokwani, Deepak K., Tiwari, Shailee V., Azad, Rajaram, Burra, Prasad V.L.S., Thopate, Shankar R.

“…[Display omitted] •A series of novel non-Camptothecin scaffold- conformationally constrained 7,12-dihydrodibenzo[b,h][1,6] naphthyridine (8–15) and…”
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Molecular docking analysis reveals differential binding affinities of multiple classes of selective inhibitors towards cancer-associated KRAS mutants by Mullaguri, Sai Charitha, Akula, Sravani, Sahoo, Partha Sarathi, Ashireddygari, Vigneshwar Reddy, Mupparapu, Vyshnavika, Silveri, Ravalika, Prasad Burra, V L S, Kancha, Rama Krishna

“…KRAS is the most frequently mutated oncogene in solid cancers, and inhibitors that specifically target the KRAS-G12C mutant were recently approved for clinical…”
Get full text