Search Results - "Burnstock, G."

Purine and pyrimidine receptors by Burnstock, G

“…Adenosine 5'-triphosphate (ATP), in addition to its intracellular roles, acts as an extracellular signalling molecule via a rich array of receptors, which have…”
Get full text

Physiopathological roles of P2X receptors in the central nervous system by Burnstock, G

“…Potent actions of ATP in the central nervous system (CNS) were reported in the late 1940's, but cloning and characterisation of receptors for purines and…”
Get more information

Discovery of purinergic signalling, the initial resistance and current explosion of interest by Burnstock, G

“…There has been a remarkable growth of papers published about purinergic signalling via ATP since 1972. I am most grateful to the wonderful PhD students and…”
Get full text

Purinergic signalling: past, present and future by Burnstock, G

“…The discovery of non-adrenergic, non-cholinergic neurotransmission in the gut and bladder in the early 1960's is described as well as the identification of…”
Get full text

Purinergic signalling by Burnstock, Geoffrey

“…While there were early papers about the extracellular actions of purines, the role of ATP as a purinergic neurotransmitter in nonadrenergic, noncholinergic…”
Get full text

Purinergic signalling in the lower urinary tract by Burnstock, G.

“…The aim of this review is to describe the conceptual steps contributing to our current knowledge of purinergic signalling and to consider its involvement in…”
Get full text

Historical review: ATP as a neurotransmitter by Burnstock, Geoffrey

“…Purinergic signalling is now recognized to be involved in a wide range of activities of the nervous system, including neuroprotection, central control of…”
Get full text

The journey to establish purinergic signalling in the gut by Burnstock, G.

“…Although the concept of purinergic signalling arose from experiments designed to find the identity of the non‐adrenergic, non‐cholinergic (NANC) inhibitory…”
Get full text

Evolutionary origins of the purinergic signalling system by Burnstock, G., Verkhratsky, A.

“…Purines appear to be the most primitive and widespread chemical messengers in the animal and plant kingdoms. The evidence for purinergic signalling in plants,…”
Get full text

Purinergic regulation of vascular tone and remodelling by Burnstock, G

“…1 Purinergic signalling is involved both in short-term control of vascular tone and in longer-term control of cell proliferation, migration and death involved…”
Get more information

P2X receptors in sensory neurones by Burnstock, G

“…P2X receptors are a family of ligand-gated ion channels responsive to ATP. Seven subtypes have been identified which form homo-multimeric or hetero-multimeric…”
Get full text

P2X7 receptors: channels, pores and more by Volonté, C, Apolloni, S, Skaper, S D, Burnstock, G

“…Purine nucleotides are well established as extracellular signaling molecules. P2X7 receptors (P2X7Rs) are members of the family of ionotropic ATP-gated…”
Get more information

The past, present and future of purine nucleotides as signalling molecules by Burnstock, G.

Get full text

Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death by Burnstock, G, Verkhratsky, A

“…The purinergic signalling system, which uses purines and pyrimidines as chemical transmitters, and purinoceptors as effectors, is deeply rooted in evolution…”
Get full text

Targeting the visceral purinergic system for pain control by Burnstock, G

“…Highlights ► Distension of visceral tubes and sacs, including urinary bladder, ureter and gut, is associated with pain. ► P2X3 homomultimer and P2X2/3…”
Get full text

Purinergic signalling in the pancreas in health and disease by Burnstock, G, Novak, I

“…Pancreatic cells contain specialised stores for ATP. Purinergic receptors (P2 and P1) and ecto-nucleotidases are expressed in both endocrine and exocrine…”
Get full text

Purine-mediated signalling in pain and visceral perception by Burnstock, Geoffrey

“…Receptor subtypes for purines have been identified in a variety of tissues, increasing interest in the roles of purine-mediated signalling in…”
Get full text

Purinergic system in psychiatric diseases by Cheffer, A, Castillo, A R G, Corrêa-Velloso, J, Gonçalves, M C B, Naaldijk, Y, Nascimento, I C, Burnstock, G, Ulrich, H

“…Psychiatric disorders are debilitating diseases, affecting >80 million people worldwide. There are no causal cures for psychiatric disorders and available…”
Get full text

The Concise Guide to PHARMACOLOGY 2015/16: Enzymes by Alexander, Stephen PH, Fabbro, Doriano, Kelly, Eamonn, Marrion, Neil, Peters, John A, Benson, Helen E, Faccenda, Elena, Pawson, Adam J, Sharman, Joanna L, Southan, Christopher, Davies, Jamie A

“…The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links…”
Get full text

The Concise Guide to PHARMACOLOGY 2015/16: G protein‐coupled receptors by Alexander, Stephen PH, Davenport, Anthony P, Kelly, Eamonn, Marrion, Neil, Peters, John A, Benson, Helen E, Faccenda, Elena, Pawson, Adam J, Sharman, Joanna L, Southan, Christopher, Davies, Jamie A

“…The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links…”
Get full text