Search Results - "Burns, Jonathan R."

A biomimetic DNA-based channel for the ligand-controlled transport of charged molecular cargo across a biological membrane by Burns, Jonathan R., Seifert, Astrid, Fertig, Niels, Howorka, Stefan

“…A DNA-based channel that undergoes a nanomechanical change in response to the binding of a specific ligand can be used to selectively transport small-molecule…”
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Creating complex protocells and prototissues using simple DNA building blocks by Arulkumaran, Nishkantha, Singer, Mervyn, Howorka, Stefan, Burns, Jonathan R.

“…Building synthetic protocells and prototissues hinges on the formation of biomimetic skeletal frameworks. Recreating the complexity of cytoskeletal and…”
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Synthetic protein-conductive membrane nanopores built with DNA by Diederichs, Tim, Pugh, Genevieve, Dorey, Adam, Xing, Yongzheng, Burns, Jonathan R., Hung Nguyen, Quoc, Tornow, Marc, Tampé, Robert, Howorka, Stefan

“…Nanopores are key in portable sequencing and research given their ability to transport elongated DNA or small bioactive molecules through narrow transmembrane…”
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Multi-functional DNA nanostructures that puncture and remodel lipid membranes into hybrid materials by Birkholz, Oliver, Burns, Jonathan R., Richter, Christian P., Psathaki, Olympia E., Howorka, Stefan, Piehler, Jacob

“…Synthetically replicating key biological processes requires the ability to puncture lipid bilayer membranes and to remodel their shape. Recently developed…”
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Design, assembly, and characterization of membrane-spanning DNA nanopores by Lanphere, Conor, Offenbartl-Stiegert, Daniel, Dorey, Adam, Pugh, Genevieve, Georgiou, Elena, Xing, Yongzheng, Burns, Jonathan R., Howorka, Stefan

“…DNA nanopores are bio-inspired nanostructures that control molecular transport across lipid bilayer membranes. Researchers can readily engineer the structure…”
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Antimicrobial peptide capsids of de novo design by De Santis, Emiliana, Alkassem, Hasan, Lamarre, Baptiste, Faruqui, Nilofar, Bella, Angelo, Noble, James E., Micale, Nicola, Ray, Santanu, Burns, Jonathan R., Yon, Alexander R., Hoogenboom, Bart W., Ryadnov, Maxim G.

“…The spread of bacterial resistance to antibiotics poses the need for antimicrobial discovery. With traditional search paradigms being exhausted, approaches…”
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Stability and dynamics of membrane-spanning DNA nanopores by Maingi, Vishal, Burns, Jonathan R., Uusitalo, Jaakko J., Howorka, Stefan, Marrink, Siewert J., Sansom, Mark S. P.

“…Recently developed DNA-based analogues of membrane proteins have advanced synthetic biology. A fundamental question is how hydrophilic nanostructures reside in…”
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Sizing up DNA nanostructure assembly with native mass spectrometry and ion mobility by van Dyck, Jeroen F., Burns, Jonathan R., Le Huray, Kyle I. P., Konijnenberg, Albert, Howorka, Stefan, Sobott, Frank

“…Recent interest in biological and synthetic DNA nanostructures has highlighted the need for methods to comprehensively characterize intermediates and end…”
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Structural and Functional Stability of DNA Nanopores in Biological Media by Burns, Jonathan R, Howorka, Stefan

“…DNA nanopores offer a unique nano-scale foothold at the membrane interface that can help advance the life sciences as biophysical research tools or…”
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Self-Assembled DNA Nanopores That Span Lipid Bilayers by Burns, Jonathan R, Stulz, Eugen, Howorka, Stefan

“…DNA nanotechnology excels at rationally designing bottom-up structures that can functionally replicate naturally occurring proteins. Here we describe the…”
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A Porphyrin-DNA Chiroptical Molecular Ruler With Base Pair Resolution by Burns, Jonathan R, Wood, James W, Stulz, Eugen

“…DNA-based molecular rulers enable scientists to determine important parameters across biology, from the measurement of protein binding interactions, to the…”
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Introducing Bacteria and Synthetic Biomolecules along Engineered DNA Fibers by Burns, Jonathan R.

“…Deoxyribonucleic acid (DNA) nanotechnology enables user‐defined structures to be built with unrivalled control. The approach is currently restricted across the…”
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Defined Bilayer Interactions of DNA Nanopores Revealed with a Nuclease-Based Nanoprobe Strategy by Burns, Jonathan R, Howorka, Stefan

“…DNA nanopores are a recent class of bilayer-puncturing nanodevices that can help advance biosensing, synthetic biology, and nanofluidics. Here, we create…”
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DNA Nanodevices with Selective Immune Cell Interaction and Function by Arulkumaran, Nishkantha, Lanphere, Conor, Gaupp, Charlotte, Burns, Jonathan R, Singer, Mervyn, Howorka, Stefan

“…DNA nanotechnology produces precision nanostructures of defined chemistry. Expanding their use in biomedicine requires designed biomolecular interaction and…”
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Directed formation of DNA nanoarrays through orthogonal self-assembly by Burns, Jonathan R, Zekonyte, Jurgita, Siligardi, Giuliano, Hussain, Rohanah, Stulz, Eugen

“…We describe the synthesis of terpyridine modified DNA strands which selectively form DNA nanotubes through orthogonal hydrogen bonding and metal complexation…”
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DNA as supramolecular scaffold for functional molecules: progress in DNA nanotechnology by Bandy, Thomas J, Brewer, Ashley, Burns, Jonathan R, Marth, Gabriella, Nguyen, Thaonguyen, Stulz, Eugen

“…Oligonucleotides have recently gained increased attraction as a supramolecular scaffold for the design and synthesis of functional molecules on the nanometre…”
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Membrane-Spanning DNA Nanopores with Cytotoxic Effect by Burns, Jonathan R., Al-Juffali, Noura, Janes, Sam M., Howorka, Stefan

“…DNA‐based cytotoxic agents: Nanopores composed of folded DNA featuring a hydrophobic belt of ethyl phosphorothioate groups insert into bilayer membranes and…”
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Bilayer-Spanning DNA Nanopores with Voltage-Switching between Open and Closed State by Seifert, Astrid, Göpfrich, Kerstin, Burns, Jonathan R, Fertig, Niels, Keyser, Ulrich F, Howorka, Stefan

“…Membrane-spanning nanopores from folded DNA are a recent example of biomimetic man-made nanostructures that can open up applications in biosensing, drug…”
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Lipid-Bilayer-Spanning DNA Nanopores with a Bifunctional Porphyrin Anchor by Burns, Jonathan R., Göpfrich, Kerstin, Wood, James W., Thacker, Vivek V., Stulz, Eugen, Keyser, Ulrich F., Howorka, Stefan

“…Holding tight: An artificial membrane nanopore assembled from DNA oligonucleotides carries porphyrin tags (red), which anchor the nanostructure into the lipid…”
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Lipidated DNA Nanostructures Target and Rupture Bacterial Membranes by Bennett, Isabel D., Burns, Jonathan R., Ryadnov, Maxim G., Howorka, Stefan, Pyne, Alice L. B.

“…Chemistry has the power to endow supramolecular nanostructures with new biomedically relevant functions. Here it is reported that DNA nanostructures modified…”
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