Search Results - "Burns, James M"

A step forward for an attenuated blood-stage malaria vaccine by Burns, Jr, James M

“…Efforts to develop an effective malaria vaccine have encountered multiple challenges, and have had limited success to date. As the need remains urgent, novel…”
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Maintaining immunogenicity of blood stage and sexual stage subunit malaria vaccines when formulated in combination by Parzych, Elizabeth M, Miura, Kazutoyo, Long, Carole A, Burns, Jr, James M

“…Eradication of Plasmodium falciparum malaria will likely require a multivalent vaccine, but the development of a highly efficacious subunit-based formulation…”
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Host-parasite interactions revealed by Plasmodium falciparum metabolomics by Olszewski, Kellen L, Morrisey, Joanne M, Wilinski, Daniel, Burns, James M, Vaidya, Akhil B, Rabinowitz, Joshua D, Llinás, Manuel

“…Intracellular pathogens have devised mechanisms to exploit their host cells to ensure their survival and replication. The malaria parasite Plasmodium…”
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Na+ Influx Induced by New Antimalarials Causes Rapid Alterations in the Cholesterol Content and Morphology of Plasmodium falciparum by Das, Sudipta, Bhatanagar, Suyash, Morrisey, Joanne M, Daly, Thomas M, Burns, Jr, James M, Coppens, Isabelle, Vaidya, Akhil B

“…Among the several new antimalarials discovered over the past decade are at least three clinical candidate drugs, each with a distinct chemical structure, that…”
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Design and Evaluation of Chimeric Plasmodium falciparum Circumsporozoite Protein-Based Malaria Vaccines by Stump, William H, Klingenberg, Hayley J, Ott, Amy C, Gonzales, Donna M, Burns, Jr, James M

“…Efficacy data on two malaria vaccines, RTS,S and R21, targeting circumsporozoite protein ( CSP), are encouraging. Efficacy may be improved by induction of…”
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Inclusion of an Optimized Plasmodium falciparum Merozoite Surface Protein 2-Based Antigen in a Trivalent, Multistage Malaria Vaccine by Eacret, Jacqueline S, Parzych, Elizabeth M, Gonzales, Donna M, Burns, Jr, James M

“…merozoite surface protein ( MSP)2 is a target of parasite-neutralizing Abs. Inclusion of recombinant MSP2 (r MSP2) as a component of a multivalent malaria…”
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A Chimeric Plasmodium falciparum Merozoite Surface Protein Vaccine Induces High Titers of Parasite Growth Inhibitory Antibodies by Alaro, James R, Partridge, Andrea, Miura, Kazutoyo, Diouf, Ababacar, Lopez, Ana M, Angov, Evelina, Long, Carole A, Burns, Jr, James M

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Immunization with merozoite surface protein 2 fused to a Plasmodium-specific carrier protein elicits strain-specific and strain-transcending, opsonizing antibody by Eacret, Jacqueline S., Gonzales, Donna M., Franks, Raymond G., Burns, James M.

“…Vaccine trials and cohort studies in Plasmodium falciparum endemic areas indicate that naturally-acquired and vaccine-induced antibodies to merozoite surface…”
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Enhanced Protection against Malaria by a Chimeric Merozoite Surface Protein Vaccine by Shi, Qifang, Lynch, Michelle M, Romero, Margarita, Burns, James M. Jr

“…The 42-kDa processed fragment of Plasmodium falciparum merozoite surface protein 1 (MSP-1₄₂) is a prime candidate for a blood-stage malaria vaccine. Merozoite…”
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γδ T Cells but Not NK Cells Are Essential for Cell-Mediated Immunity against Plasmodium chabaudi Malaria by Weidanz, William P, LaFleur, GayeLyn, Brown, Andrew, Burns, James M. Jr, Gramaglia, Irene, van der Heyde, Henri C

“…Blood-stage Plasmodium chabaudi infections are suppressed by antibody-mediated immunity and/or cell-mediated immunity (CMI). To determine the contributions of…”
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Immunogenicity of a chimeric Plasmodium falciparum merozoite surface protein vaccine in Aotus monkeys by Burns, Jr, James M, Miura, Kazutoyo, Sullivan, JoAnn, Long, Carole A, Barnwell, John W

“…The production of properly folded, recombinant sub-unit Plasmodium falciparum malaria vaccine candidates in sufficient quantities is often a challenge. Success…”
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Elevated Levels of the Plasmodium yoelii Homologue of Macrophage Migration Inhibitory Factor Attenuate Blood-Stage Malaria by Thorat, Swati, Daly, Thomas M, Bergman, Lawrence W, Burns, James M. Jr

“…The excessive production of proinflammatory cytokines plays a significant role in the pathogenesis of severe malaria. Mammalian macrophage migration inhibitory…”
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Evaluation of the Immunogenicity and Vaccine Potential of Recombinant Plasmodium falciparum Merozoite Surface Protein 8 by ALARO, James R, ANGOV, Evelina, LOPEZ, Ana M, HONG ZHOU, LONG, Carole A, BURNS, James M

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Host erythrocyte environment influences the localization of exported protein 2, an essential component of the Plasmodium translocon by Meibalan, Elamaran, Comunale, Mary Ann, Lopez, Ana M, Bergman, Lawrence W, Mehta, Anand, Vaidya, Akhil B, Burns, Jr, James M

“…Malaria parasites replicating inside red blood cells (RBCs) export a large subset of proteins into the erythrocyte cytoplasm to facilitate parasite growth and…”
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Protective immune responses elicited by immunization with a chimeric blood-stage malaria vaccine persist but are not boosted by Plasmodium yoelii challenge infection by Alaro, James R, Lynch, Michele M, Burns, James M

“…Abstract An efficacious malaria vaccine remains elusive despite concerted efforts. Using the Plasmodium yoelii murine model, we previously reported that…”
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Remarkable stability in patterns of blood-stage gene expression during episodes of non-lethal Plasmodium yoelii malaria by Cernetich-Ott, Amy, Daly, Thomas M, Vaidya, Akhil B, Bergman, Lawrence W, Burns, Jr, James M

“…Microarray studies using in vitro cultures of synchronized, blood-stage Plasmodium falciparum malaria parasites have revealed a 'just-in-time' cascade of gene…”
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Suppression of lethal Plasmodium yoelii malaria following protective immunization requires antibody-, IL-4-, and IFN-gamma-dependent responses induced by vaccination and/or challenge infection by Petritus, Patricia M, Burns, Jr, James M

“…Immunization with Plasmodium yoelii merozoite surface protein (PyMSP)-8 protects mice from lethal malaria but does not prevent infection. Using this merozoite…”
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Prediction of Merozoite Surface Protein 1 and Apical Membrane Antigen 1 Vaccine Efficacies against Plasmodium chabaudi Malaria Based on Prechallenge Antibody Responses by Lynch, Michelle M., Cernetich-Ott, Amy, Weidanz, William P., Burns, James M.

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Evaluation of a Plasmodium-Specific Carrier Protein To Enhance Production of Recombinant Pfs25, a Leading Transmission-Blocking Vaccine Candidate by Parzych, Elizabeth M, Miura, Kazutoyo, Ramanathan, Aarti, Long, Carole A, Burns, James M

“…Challenges with the production and suboptimal immunogenicity of malaria vaccine candidates have slowed the development of a Plasmodium falciparum multiantigen…”
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Protection against Plasmodium chabaudi Malaria Induced by Immunization with Apical Membrane Antigen 1 and Merozoite Surface Protein 1 in the Absence of Gamma Interferon or Interleukin-4 by BURNS, James M, FLAHERTY, Patrick R, NANAVATI, Payal, WEIDANZ, William P

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