Search Results - "Burns, DJ"

Validation of FLIPR membrane potential dye for high throughput screening of potassium channel modulators by Whiteaker, K L, Gopalakrishnan, S M, Groebe, D, Shieh, C C, Warrior, U, Burns, D J, Coghlan, M J, Scott, V E, Gopalakrishnan, M

“…A fluorescence-based assay using the FLIPR Membrane Potential Assay Kit (FMP) was evaluated for functional characterization and high throughput screening (HTS)…”
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Abstract P2-09-22: Use of a functional signal profiling test with high sensitivity and specificity to determine the prevalence of abnormal HER2-driven signaling activity in the HER2-negative breast cancer patient population: New patient group may benefit from HER2 therapy by Laing, LG, Burns, DJ, MacNeil, IA, Rich, BE, Myhre, S, Soltani, S, Sullivan, BF

“…Background: Biological factors, such as HER2 signaling activity, may be important to measure in addition to expression and amplification of HER2 when…”
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Abstract P3-10-15: Evaluating contribution of hyperactive c-Met and ErbB signaling to tumor progression in mouse breast tumor xenografts: An in vivo study of c-Met and ErbB targeted therapies by Laing, LG, Burns, DJ, Khan, S, MacNeil, IA, Rich, BE, Kharbush, SM, Soltani, SM, Sullivan, BF

“…Background: Hyperactive c-Met signaling, including cross-talk between c-Met and ErbB family receptors, is suspected of contributing to tumor progression in a…”
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Abstract P3-10-20: Sub-group of HER2- breast cancer patients with hyperactive and co-involved c-Met and ErbB pathways identified: Functional signal profiling test identifies patient group that may benefit from c-Met and pan-HER combination therapy by Laing, LG, Burns, DJ, Khan, S, MacNeil, IA, Rich, BE, Kharbush, SM, Soltani, SM, Sullivan, BF

“…Background: Biological factors other than c-Met status, such as c-Met and ErbB signaling activity, may be important to measure when identifying patients…”
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Abstract P2-05-05: Evaluation of pan-HER and c-MET inhibitors tested ex vivo in primary HER2- breast cancer cells with hyperactive c-MET and ErbB family signaling by Laing, LG, Burns, DJ, Khan, S, MacNeil, IA, Rich, BE, Kharbush, SM, Soltani, SM, Sullivan, BF

“…Background: To elucidate the role of c-Met signaling and its involvement with ErbB signaling as a cancer driver, a new assay using an impedance biosensor, the…”
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Estrogen receptor-α mediates gene expression changes and growth response in ovarian cancer cells exposed to estrogen by O’Donnell, Amanda J M, Macleod, Kenneth G, Burns, David J, Smyth, John F, Langdon, Simon P

“…Estrogens play a significant role in the development, growth, invasion and metastasis of ovarian tumors. The transcriptional program regulated by 17β-estradiol…”
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Lipid activation of protein kinase C by Bell, R M, Burns, D J

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Discovery of novel inhibitors of Bcl-xL using multiple high-throughput screening platforms by Qian, Jie, Voorbach, Martin J, Huth, Jeffrey R, Coen, Michael L, Zhang, Haichao, Ng, Shi-Chung, Comess, Kenneth M, Petros, Andrew M, Rosenberg, Saul H, Warrior, Usha, Burns, David J

“…Bcl-xL is a member of the Bcl-2 family of proteins that are implicated to play a vital role in several diseases including cancer. Bcl-xL suppresses apoptosis;…”
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Integration of NMR and high-throughput screening by Hajduk, Philip J, Burns, David J

“…NMR-based screening has become a powerful method for the identification and analysis of low-molecular weight organic compounds that bind to protein targets and…”
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Using cumulative-recall curves to assess the extent of relational and item-specific processing by Burns, Daniel, Hebert, Theresa

“…Although distinguishing between item-specific and relational information has proved to be a useful approach for understanding a variety of important memory…”
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Regulation of phospholipase D by protein kinase C in human neutrophils. Conventional isoforms of protein kinase C phosphorylate a phospholipase D-related component in the plasma membrane by Lopez, I, Burns, D J, Lambeth, J D

“…In a variety of intact cells, phorbol esters are known to activate phospholipase D. In a cell-free system consisting of plasma membrane and cytosol from human…”
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A system for automatic electrical and optical characterization of microelectromechanical devices by Burns, D.J., Helbig, H.F.

“…A new optical method for characterizing the performance of microelectromechanical systems (MEMS) is described that is significantly faster and simpler than…”
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The development of a college biology self-efficacy instrument for nonmajors by Baldwin, Julie A., Ebert-May, Diane, Burns, Dennis J.

“…In an effort to test the effectiveness of teaching and learning strategies that may increase biological literacy for nonbiology majors, an NSF‐funded research…”
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An Item Gains and Losses Analysis of False Memories Suggests Critical Items Receive More Item-Specific Processing Than List Items by Burns, Daniel J, Martens, Nicholas J, Bertoni, Alicia A, Sweeney, Emily J, Lividini, Michelle D

“…In a repeated testing paradigm, list items receiving item-specific processing are more likely to be recovered across successive tests (item gains), whereas…”
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Protein kinase C isotypes in human erythroleukemia (K562) cell proliferation and differentiation. Evidence that beta II protein kinase C is required for proliferation by MURRAY, N. R, BAUMGARDNER, G. P, BURNS, D. J, FIELDS, A. P

“…The human erythroleukemia (K562) cell line undergoes megakaryocytic differentiation and cessation of proliferation when treated with phorbol myristate acetate…”
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Identification and regulation of protein kinase C-delta in human neutrophils by Kent, JD, Sergeant, S, Burns, DJ, McPhail, LC

“…The intracellular mechanisms that regulate the function of human neutrophils are not well understood. Receptor-initiated signaling events result in the…”
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The Simultaneous Acquisition Effect: Simultaneous Task Learning Inhibits Memory for Order by Burns, Daniel J.

“…Delayed recall of a list of words learned simultaneously with other lists is superior to that of a list of words learned singly. A Brown-Peterson-like task was…”
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A cell-based microarrayed compound screening format for identifying agonists of G-protein-coupled receptors by Gopalakrishnan, Sujatha M., Moreland, Robert B., Kofron, James.L., Helfrich, Rosalind J., Gubbins, Earl, McGowen, Jennifer, Masters, Jeffrey N., Donnelly-Roberts, Diana, Brioni, Jorge D., Burns, David.J., Warrior, Usha

“…The identification of agonist and antagonist leads for G-protein-coupled receptors (GPCRs) is of critical importance to the pharmaceutical and biotechnology…”
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Microarrayed compound screening (microARCS) to identify activators and inhibitors of AMP-activated protein kinase by Anderson, Steven N, Cool, Barbara L, Kifle, Lemma, Chiou, William, Egan, David A, Barrett, Leo W, Richardson, Paul L, Frevert, Ernst U, Warrior, Usha, Kofron, James L, Burns, David J

“…A novel and innovative high-throughput screening assay was developed to identify both activators and inhibitors of AMP-activated protein kinase (AMPK) using…”
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Identification of protein kinase C (PKC) phosphorylation sites on human lamin B. Potential role of PKC in nuclear lamina structural dynamics by HOCEVAR, B. A, BURNS, D. J, FIELDS, A. P

“…Protein kinase C (PKC) is activated at the nuclear membrane in response to a variety of mitogenic stimuli. In human leukemic cells, the beta II PKC isotype is…”
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