Search Results - "Burns, Colin S."

Prothymosin-α inhibits HIV-1 via Toll-like receptor 4-mediated type I interferon induction by Mosoian, Arevik, Teixeira, Avelino, Burns, Colin S, Sander, Leif E, Gusella, G. Luca, He, Cijiang, Blander, J. Magarian, Klotman, Paul, Klotman, Mary E

“…Induction of type I interferons (IFN) is a central feature of innate immune responses to microbial pathogens and is mediated via Toll-like receptor…”
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Copper Coordination in the Full-Length, Recombinant Prion Protein by Burns, Colin S, Aronoff-Spencer, Eliah, Legname, Giuseppe, Prusiner, Stanley B, Antholine, William E, Gerfen, Gary J, Peisach, Jack, Millhauser, Glenn L

“…The prion protein (PrP) binds divalent copper at physiologically relevant conditions and is believed to participate in copper regulation or act as a…”
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Manganese Transporter MntH Is a Critical Virulence Determinant for Brucella abortus 2308 in Experimentally Infected Mice by Anderson, Eric S, Paulley, James T, Gaines, Jennifer M, Valderas, Michelle W, Martin, Daniel W, Menscher, Evan, Brown, Timothy D, Burns, Colin S, Roop, R. Martin II

“…The gene designated BAB1_1460 in the Brucella abortus 2308 genome sequence is predicted to encode the manganese transporter MntH. Phenotypic analysis of an…”
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Molecular Features of the Copper Binding Sites in the Octarepeat Domain of the Prion Protein by Burns, Colin S, Aronoff-Spencer, Eliah, Dunham, Christine M, Lario, Paula, Avdievich, Nikolai I, Antholine, William E, Olmstead, Marilyn M, Vrielink, Alice, Gerfen, Gary J, Peisach, Jack, Scott, William G, Millhauser, Glenn L

“…Recent evidence suggests that the prion protein (PrP) is a copper binding protein. The N-terminal region of human PrP contains four sequential copies of the…”
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Copper and Zinc Promote Interactions between Membrane-Anchored Peptides of the Metal Binding Domain of the Prion Protein by Kenward, Angela G, Bartolotti, Libero J, Burns, Colin S

“…The prion protein (PrP) has been identified as a metalloprotein capable of binding multiple copper ions and possibly zinc. Recent studies now indicate that…”
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Identification of the Cu2+ Binding Sites in the N-Terminal Domain of the Prion Protein by EPR and CD Spectroscopy by Aronoff-Spencer, Eliah, Burns, Colin S, Avdievich, Nikolai I, Gerfen, Gary J, Peisach, Jack, Antholine, William E, Ball, Haydn L, Cohen, Fred E, Prusiner, Stanley B, Millhauser, Glenn L

“…Recent evidence indicates that the prion protein (PrP) plays a role in copper metabolism in the central nervous system. The N-terminal region of human PrP…”
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Zn2+-binding in the glutamate-rich region of the intrinsically disordered protein prothymosin-alpha by Garapati, Sriramya, Monteith, William, Wilson, Chris, Kostenko, Anastasiia, Kenney, John M., Danell, Allison S., Burns, Colin S.

“…Prothymosin-α is a small, multifunctional intrinsically disordered protein associated with cell survival and proliferation which binds multiple Zn 2+ ions and…”
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Calorimetric Investigation of Copper Binding in the N‑Terminal Region of the Prion Protein at Low Copper Loading: Evidence for an Entropically Favorable First Binding Event by Gogineni, Devi Praneetha, Spuches, Anne M, Burns, Colin S

“…Although the Cu2+-binding sites of the prion protein have been well studied when the protein is fully saturated by Cu2+, the Cu2+-loading mechanism is just…”
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Identification of the Copper(II) Coordinating Residues in the Prion Protein by Metal-Catalyzed Oxidation Mass Spectrometry: Evidence for Multiple Isomers at Low Copper(II) Loadings by Srikanth, Rapole, Wilson, Jonathan, Burns, Colin S, Vachet, Richard W

“…While the Cu(II) binding sites of the prion protein have been well studied under Cu-saturation conditions, the identity of the residues involved in…”
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The 4-pyridylmethyl ester as a protecting group for glutamic and aspartic acids: 'flipping' peptide charge states for characterization by positive ion mode ESI-MS by Garapati, Sriramya, Burns, Colin S.

“…Use of the 4‐pyridylmethyl ester group for side‐chain protection of glutamic acid residues in solid‐phase peptide synthesis enables switching of the charge…”
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Peculiarities of Copper Binding to α-Synuclein by Ahmad, Atta, Burns, Colin S., Fink, Anthony L., Uversky, Vladimir N.

“…Heavy metals have been implicated as the causative agents for the pathogenesis of the most prevalent neurodegenerative disease. Various mechanisms have been…”
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Zinc Deposition During ESI-MS Analysis of Peptide-Zinc Complexes by Mattapalli, Haritha, Monteith, William B., Burns, Colin S., Danell, Allison S.

“…Electrospray ionization (ESI) mass spectrometry (MS) has proven to be an extremely powerful technique for studying the stoichiometry and binding strength of…”
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Influence of Prothymosin-α on HIV-1 Target Cells by MOSOIAN, AREVIK, TEIXEIRA, AVELINO, BURNS, COLIN S., KHITROV, GREGORY, ZHANG, WEIJIA, GUSELLA, LUCA, KLOTMAN, PAUL, KLOTMAN, MARY

“…:  The important role of CD8+ T cells in controlling HIV‐1 infection through the innate as well as the adaptive immune system is well established. In addition…”
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Mechanism for Formation of the Lightstruck Flavor in Beer Revealed by Time-Resolved Electron Paramagnetic Resonance by Burns, Colin S., Heyerick, Arne, De Keukeleire, Denis, Forbes, Malcolm D. E.

“…Time‐resolved electron paramagnetic resonance (TREPR) data collected during the photodegradation of iso‐α‐acids (isohumulones), the principal bittering agents…”
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Purification and characterization of the central segment of prothymosin-α: methodology for handling highly acidic peptides by Wilson, Christopher L., Monteith, William B., Danell, Allison S., Burns, Colin S.

“…Prothymosin‐α is a highly acidic protein consisting of 110 amino acids. The central segment of this protein, residues 51–89, is thought to be involved in metal…”
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Neutral Peptide Biradicals Formed by Dissociative Electron Transfer by Burns, Colin S, Rochelle, Lakecia, Forbes, Malcolm D. E

“…A new method for the generation of transient neutral biradicals in liquid solution is reported. Photoinduced electron transfer in aqueous solution of the…”
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The 4-pyridylmethyl ester as a protecting group for glutamic and aspartic acids: ‘flipping’ peptide charge states for characterization by positive ion mode ESI-MS: 4-PYRIDYLMETHYL ESTER: A POLARITY SWITCHING PROTECTING GROUP IN ESI-MS by Garapati, Sriramya, Burns, Colin S.

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Field- and Temperature-Dependent 13 C NMR Studies of the EDTA–Zn 2+ Complex: Insight into Structure and Dynamics via Relaxation Measurements by Garapati, Sriramya, Burns, Colin S., Rodriguez, A. A.

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Field- and Temperature-Dependent super(13)C NMR Studies of the EDTA-Zn super(2+) Complex: Insight into Structure and Dynamics via Relaxation Measurements by Garapati, Sriramya, Burns, Colin S, Rodriguez, A A

“…The relaxation rates for the three different carbon types in EDTA (carbonyl, CH sub(2) central, and CH sub(2) lateral) were measured with and without Zn…”
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Field- and Temperature-Dependent 13C NMR Studies of the EDTA–Zn2+ Complex: Insight into Structure and Dynamics via Relaxation Measurements by Garapati, Sriramya, Burns, Colin S, Rodriguez, A. A

“…The relaxation rates for the three different carbon types in EDTA (carbonyl, CH2 central, and CH2 lateral) were measured with and without Zn2+ as a function of…”
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