Search Results - "Burnier, John"

Safety and pharmacokinetics of a novel lymphocyte function-associated antigen-1 antagonist ophthalmic solution (SAR 1118) in healthy adults by Semba, Charles P, Swearingen, Dennis, Smith, Valerie L, Newman, Mary S, O'Neill, Charles A, Burnier, John P, Haughey, David B, Gadek, Thomas R

“…To investigate the safety, tolerability, and pharmacokinetics (PKs) of topical SAR 1118 Ophthalmic Solution in healthy adults. SAR 1118 is an investigational…”
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Subtiligase: A Tool for Semisynthesis of Proteins by Chang, Thomas K., Jackson, David Y., Burnier, John P., Wells, James A.

“…A variant of subtilisin BPN', which we call subtiligase, has been used to ligate esterified peptides site-specifically onto the N termini of proteins or…”
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Engineering subtilisin and its substrates for efficient ligation of peptide bonds in aqueous solution by Abrahmsen, Lars, Tom, Jeffrey, Burnier, John, Butcher, Karen A, Kossiakoff, Anthony, Wells, James A

“…Protein engineering techniques were used to construct a derivative of the serine protease subtilisin that ligates peptides efficiently in water. The subtilisin…”
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Determination of the Solution Structure of the Peptide Hormone Guanylin: Observation of a Novel Form of Topological Stereoisomerism by Skelton, Nicholas J, Garcia, K. Christopher, Goeddel, David V, Quan, Clifford, Burnier, John P

“…Guanylin is a 15 amino acid mammalian hormone containing two disulfide bonds. Guanylin shares sequence similarity with the bacterial heat-stable enterotoxin…”
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Tetrapeptide Inhibitors of Protein Farnesyltransferase: Amino-Terminal Substitution in Phenylalanine-Containing Tetrapeptides Restores Farnesylation by Brown, Michael S., Goldstein, Joseph L., Paris, Kenneth J., Burnier, John P., James C. Marsters, Jr

“…Protein farnesyltransferase from rat brain transfers farnesyl residues to cysteine residues in tetrapeptides that conform to the sequence CA1A2X, where C is…”
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Enzymic Cyclization of Linear Peptide Esters Using Subtiligase by Jackson, David Y, Burnier, John P, Wells, James A

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Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye by Zhong, Min, Gadek, Thomas R, Bui, Minna, Shen, Wang, Burnier, John, Barr, Kenneth J, Hanan, Emily J, Oslob, Johan D, Yu, Chul H, Zhu, Jiang, Arkin, Michelle R, Evanchik, Marc J, Flanagan, W. Mike, Hoch, Ute, Hyde, Jennifer, Prabhu, Saileta, Silverman, Jeffrey A, Wright, Jasmin

“…LFA-1/ICAM-1 interaction is essential in support of inflammatory and specific T-cell regulated immune responses by mediating cell adhesion, leukocyte…”
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Substrate specificities of growth factor associated kallikreins of the mouse submandibular gland by Blaber, Michael, Isackson, Paul J, Marsters, James C, Burnier, John P, Bradshaw, Ralph A

“…The kinetic constants for the hydrolysis of a series of tripeptide p-nitroanilide substrates by mouse epidermal growth factor binding protein (EGF-BP), the…”
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Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity by HIGASHIJIMA, T, BURNIER, J, ROSS, E. M

“…Mastoparan (MP), a cationic, amphiphilic tetradecapeptide, stimulates guanine nucleotide exchange by GTP-binding regulatory proteins (G proteins) in a manner…”
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A Designed Peptide Ligase for Total Synthesis of Ribonuclease A with Unnatural Catalytic Residues by Jackson, David Y., Burnier, John, Quan, Clifford, Stanley, Mark, Tom, Jeffrey, Wells, James A.

“…An engineered variant of subtilisin BPN′, termed subtiligase, which efficiently ligates esterified peptides in aqueous solution, was used for the complete…”
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In vitro characterization of four novel classes of growth hormone-releasing peptide by Elias, K A, Ingle, G S, Burnier, J P, Hammonds, R G, McDowell, R S, Rawson, T E, Somers, T C, Stanley, M S, Cronin, M J

“…Reexamination of the hexapeptide GH-releasing peptide (GHRP-6) structure/function has lead to the development of four novel classes of compound that stimulate…”
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From Peptide to Non-Peptide. 1. The Elucidation of a Bioactive Conformation of the Arginine-Glycine-Aspartic Acid Recognition Sequence by McDowell, Robert S, Gadek, Thomas R, Barker, Peter L, Burdick, Daniel J, Chan, Kathyrn S, Quan, Clifford L, Skelton, Nicholas, Struble, Martin, Thorsett, Eugene D

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A peptide derived from the amino terminus of endothelial-monocyte-activating polypeptide II modulates mononuclear and polymorphonuclear leukocyte functions, defines an apparently novel cellular interaction site, and induces an acute inflammatory response by KAO, J, FAN, Y.-G, BURNIER, J, STERN, D, HAEHNEL, I, BRETT, J, GREENBERG, S, CLAUSS, M, KAYTON, M, HOUCK, K, KISIEL, W, SELJELID, R

“…Endothelial-monocyte-activating polypeptide II (EMAP II) is a novel mediator isolated from conditioned medium of methylcholanthrene A-induced tumor cells which…”
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Growth Hormone Secretagogues: Characterization, Efficacy, and Minimal Bioactive Conformation by McDowell, Robert S., Elias, Kathleen A., Stanley, Mark S., Burdick, Daniel J., Burnier, John P., Chan, Kathryn S., Fairbrother, Wayne J., Hammonds, R. Glenn, Gladys S.Ingle, Jacobsen, Neil E., Mortensen, Deborah L., Rawson, Thomas E., Won, Wesley B., Clark, Ross G., Somers, Todd C.

“…Another class of growth hormone (GH) secretagogues has been discovered by altering the backbone structure of a flexible linear GH-releasing peptide (GHRP). In…”
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The kinetics of relaxin oxidation by hydrogen peroxide by NGUYEN, T. H, BURNIER, J, WEI MENG

“…In this study, hydrogen peroxide was used to study the oxidation of rhRlx under various conditions. Oxidation of rhRlx occurred at both of the two methionines…”
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Extracellular domain-IgG fusion proteins for three human natriuretic peptide receptors. Hormone pharmacology and application to solid phase screening of synthetic peptide antisera by BENNETT, B. D, BENNETT, G. L, VITANGCOL, R. V, JEWETT, J. R. S, BURNIER, J, HENZEL, W, LOWE, D. G

“…The natriuretic peptide receptors (NPRs) are a family of three cell surface glycoproteins, each with a single transmembrane domain. Two of these receptors,…”
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Engineering subtilisin BPN' for site-specific proteolysis by Carter, P, Nilsson, B, Burnier, J P, Burdick, D, Wells, J A

“…A combination of protein engineering and substrate optimization was used to create variants of the serine protease, subtilisin BPN', which efficiently and…”
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Agonist selectivity for three species of natriuretic peptide receptor-A by Schoenfeld, J R, Sehl, P, Quan, C, Burnier, J P, Lowe, D G

“…We determined the nucleotide sequence of mouse natriuretic peptide receptor-A (NPR-A) cDNA and compared the revised deduced amino acid sequence with those of…”
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Isolation and properties of a soluble sialidase from the culture fluid of Chinese hamster ovary cells by Warner, T G, Chang, J, Ferrari, J, Harris, R, McNerney, T, Bennett, G, Burnier, J, Sliwkowski, M B

“…A soluble sialidase that can degrade recombinant glycoproteins expressed in Chinese hamster ovary (CHO) cells has been isolated and purified to near…”
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Cyclic RGD peptide analogs as antiplatelet antithrombotics by Barker, Peter L, Bullens, Sherron, Bunting, Stuart, Burdick, Daniel J, Chan, Kathryn S, Deisher, Tracy, Eigenbrot, Charles, Gadek, Thomas R, Gantzos, Robin

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