Search Results - "Burnham, W.M."

5. Novel anticonvulsant effects of supraphysiological doses of progesterone in hippocampal-kindled mice by Jeffrey, Melanie, Zhang, Liang, Burnham, W.M

“…Background Progesterone is a known anticonvulsant. Progesterone’s anticonvulsant effects are generally attributed to its secondary metabolite, 5 α ,3 α…”
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5. The effects of progesterone, DHP, and THP on spontaneous inter ictal discharges in CA3 electrically kindled mice by Jeffrey, Melanie A, Lang, Min, Burnham, W.M, Zhang, Liang

“…Progesterone is an anticonvulsant neurosteroid. It is reduced by the unidirectional enzyme 5 α -reductase to 5 α -dihydroprogesterone (DHP) and subsequently…”
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Selective reduction of excitatory hippocampal sharp waves by docosahexaenoic acid and its methyl ester analog ex-vivo by Taha, Ameer Y, Zahid, Tariq, Epps, Tina, Trepanier, Marc-Olivier, Burnham, W.M, Bazinet, Richard P, Zhang, Liang

“…Abstract Excitatory sharp waves (SPWs) originating from the hippocampus are considered to model the interictal “spikes” that occur in people with temporal lobe…”
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1. Daily DHA injections raise seizure thresholds and blood but not brain free DHA levels in rats by Trépanier, Marc-Olivier, Taha, Ameer Y, Bazinet, Richard P, Burnham, W.M

“…Background Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid ( n −3 PUFA), which has previously shown to have anticonvulsant activity rats…”
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A minimum of 3 months of dietary fish oil supplementation is required to raise amygdaloid afterdischarge seizure thresholds in rats - implications for treating complex partial seizures by Taha, Ameer Y, Trepanier, Marc-Olivier, Ciobanu, Flaviu A, Taha, Nadeen M, Ahmed, Muaz, Zeng, Qiudi, Cheuk, Waiyin I, Ip, Bryan, Filo, Elvis, Scott, Brian W, Burnham, W.M, Bazinet, Richard P

“…Abstract Complex partial seizures, which typically originate in limbic structures such as the amygdala, are often resistant to antiseizure medications. Our…”
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Acute administration of docosahexaenoic acid increases resistance to pentylenetetrazol-induced seizures in rats by Taha, Ameer Y, Jeffrey, Melanie A, Taha, Nadeen M.Y, Bala, Saimir, Burnham, W.M

“…Abstract Objective Docosahexaenoic acid (DHA), an omega-3 fatty acid, has been reported to raise seizure thresholds. The purpose of the present study was to…”
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Intraperitoneal administration of docosahexaenoic acid for 14days increases serum unesterified DHA and seizure latency in the maximal pentylenetetrazol model by Trépanier, Marc-Olivier, Lim, Joonbum, Lai, Terence K.Y., Cho, Hye Jin, Domenichiello, Anthony F., Chen, Chuck T., Taha, Ameer Y., Bazinet, Richard P., Burnham, W.M.

“…Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid (n−3 PUFA) which has been shown to raise seizure thresholds following acute administration…”
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Increases in seizure latencies induced by subcutaneous docosahexaenoic acid are lost at higher doses by Trépanier, Marc-Olivier, Taha, Ameer Y, Mantha, Rebecca L, Ciobanu, Flaviu A, Zeng, Qiudi H, Tchkhartichvili, George M, Domenichiello, Anthony F, Bazinet, Richard P, Burnham, W.M

“…Summary Docosahexaenoic acid (DHA) is a polyunsaturated fatty acid (PUFA) which has been found to have anticonvulsant properties. Our group has previously…”
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The effects of a ketogenic diet on ATP concentrations and the number of hippocampal mitochondria in Aldh5a1 −/− mice by Nylen, Kirk, Velazquez, Jose Luis Perez, Sayed, Venus, Gibson, K. Michael, Burnham, W.M., Snead, O. Carter

“…Succinic semialdehyde dehydrogenase (SSADH) deficiency is an inborn error of GABA metabolism characterized clinically by ataxia, psychomotor retardation and…”
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9. Anti-convulsant doses of 5-alpha-dihydroprogesterone: Behavioural toxicity results and possible mechanisms of action by Jeffrey, M, Lonsdale, D, Burnham, W.M

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Dose response effects of the cannabinoids as anti-seizure drugs in amygdala kindled rats by Fallah, M., Burnham, W.M.

“…Focal Impaired Awareness Seizures of temporal lobe origin (FIAS, also called “complex partial” seizures) are the most common seizures in adults, and are…”
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Intravenous infusion of docosahexaenoic acid increases serum concentrations in a dose-dependent manner and increases seizure latency in the maximal PTZ model by Trépanier, Marc-Olivier, Kwong, Kei-Man, Domenichiello, Anthony F, Chen, Chuck T, Bazinet, Richard P, Burnham, W.M

“…Abstract Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid (n − 3 PUFA) that has been shown to raise seizure thresholds in the maximal…”
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6. Mechanisms of the ketogenic diet’s efficacy in succinic semialdehyde dehydrogenase deficiency by Nylen, Kirk, Likhodii, Sergei, Perez Velasquez, Jose Luis, Burnham, W.M, Gibson, K. Michael, Snead, O. Carter

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Cytogenesis in the adult rat dentate gyrus is increased following kindled seizures but is unaltered in pharmacological models of absence seizures by Scott, B.W, Chan, K.F.Y, Wong, G, Ahmed, M, Chieverton, L, Liu, R.R, Wood, J, Burnham, W.M

“…Abstract The production of new neurons continues throughout adulthood in the dentate gyrus of the hippocampal formation, and is believed to play a role in…”
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The ketogenic diet rescues the lethal phenotype and restores synaptic activity in succinic semialdehyde dehydrogenase deficient mice by Nylen, Kirk, Likhodii, Sergei, Perez Velasquez, Jose Luis, Burnham, W.M, Gibson, K. Michael, Snead, O. Carter

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P2-389: Metabolic treatments for Alzheimer's disease by Costantini, Lauren C, Studzinski, C.M, Araujo, J.A, MacKay, W.A, Webb, R.L, Beckett, T.L, Murphy, M.P, Sullivan, P.G, Burnham, W.M, Milgram, N.W, Vogel, J, Barr, L, Henderson, S.T

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The behavioral effects of CBD and THC in mouse models of psychosis by Li, C.K., Mielnik, C.A., Ramsey, A.J., Ross, R.A., Burnham, W.M.

“…Approximately 10% of the patients with long-term temporal-lobe epilepsy develop psychotic symptoms, which are known as the “psychosis of epilepsy” (POE). The…”
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1. The development of propagated discharge and behavioural arrest in hippocampal and amygdala kindled seizures by Mohamed, J., Scott, B.W., David, O., Burnham, W.M.

“…Patients with focal temporal lobe seizures often experience transient episodes of impaired awareness with behavioural arrest, but the precise mechanism remains…”
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The antidepressant properties of the ketogenic diet by Murphy, Patricia, Likhodii, Sergei, Nylen, Kirk, Burnham, W.M.

“…The ketogenic diet is used to treat epilepsy refractory to anticonvulsant medication. Individuals with epilepsy often have behavioral problems and deficits in…”
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The anticonvulsant effects of allopregnanolone against amygdala-kindled seizures in female rats by Lonsdale, Deborah, Burnham, W.M.

“…It has long been known that the steroid hormone progesterone has anticonvulsant actions. These have been documented both in animals and humans. In 2003, we…”
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