Search Results - "Burnham, W M"

Selective reduction of excitatory hippocampal sharp waves by docosahexaenoic acid and its methyl ester analog ex-vivo by Taha, Ameer Y, Zahid, Tariq, Epps, Tina, Trepanier, Marc-Olivier, Burnham, W.M, Bazinet, Richard P, Zhang, Liang

“…Abstract Excitatory sharp waves (SPWs) originating from the hippocampus are considered to model the interictal “spikes” that occur in people with temporal lobe…”
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The antidepressant properties of the ketogenic diet by Murphy, Patricia, Likhodii, Sergei, Nylen, Kirk, Burnham, W.M.

“…The ketogenic diet is used to treat epilepsy refractory to anticonvulsant medication. Individuals with epilepsy often have behavioral problems and deficits in…”
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The anticonvulsant effects of allopregnanolone against amygdala-kindled seizures in female rats by Lonsdale, Deborah, Burnham, W.M.

“…It has long been known that the steroid hormone progesterone has anticonvulsant actions. These have been documented both in animals and humans. In 2003, we…”
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Increases in seizure latencies induced by subcutaneous docosahexaenoic acid are lost at higher doses by Trépanier, Marc-Olivier, Taha, Ameer Y, Mantha, Rebecca L, Ciobanu, Flaviu A, Zeng, Qiudi H, Tchkhartichvili, George M, Domenichiello, Anthony F, Bazinet, Richard P, Burnham, W.M

“…Summary Docosahexaenoic acid (DHA) is a polyunsaturated fatty acid (PUFA) which has been found to have anticonvulsant properties. Our group has previously…”
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Comparative study of five antiepileptic drugs on a translational cognitive measure in the rat: relationship to antiepileptic property by Higgins, Guy A., Breysse, Nathalie, Undzys, Elijus, Derksen, D. Richard, Jeffrey, Melanie, Scott, Brian W., Xin, Tao, Roucard, Corinne, Bressand, Karine, Depaulis, Antoine, Burnham, W. M.

“…Rationale Antiepileptic drugs (AEDs) have been available for many years; yet, new members of this class continue to be identified and developed due to the…”
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Kindling-induced neurogenesis in the dentate gyrus of the rat by Scott, B.W, Wang, S, Burnham, W.M, De Boni, U, Wojtowicz, J.M

“…Kindling, a form of neuronal plasticity produced by repeated low intensity electrical brain stimulation, leads to epileptic seizures. To address possible…”
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Oxidative stress is involved in seizure-induced neurodegeneration in the kindling model of epilepsy by Frantseva, M.V, Perez Velazquez, J.L, Tsoraklidis, G, Mendonca, A.J, Adamchik, Y, Mills, L.R, Carlen, P.L, Burnham, M.W

“…Reactive oxygen species have been implicated in the development of seizures under pathological conditions and linked to seizure-induced neurodegeneration…”
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A ketogenic diet rescues the murine succinic semialdehyde dehydrogenase deficient phenotype by Nylen, Kirk, Velazquez, Jose Luis Perez, Likhodii, Sergei S., Cortez, Miguel A., Shen, Lily, Leshchenko, Yevgen, Adeli, Khosrow, Gibson, K. Michael, Burnham, W.M., Snead, O. Carter

“…Succinic semialdehyde dehydrogenase (SSADH) deficiency is a heritable disorder of GABA degradation characterized by ataxia, psychomotor retardation and…”
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A minimum of 3 months of dietary fish oil supplementation is required to raise amygdaloid afterdischarge seizure thresholds in rats - implications for treating complex partial seizures by Taha, Ameer Y, Trepanier, Marc-Olivier, Ciobanu, Flaviu A, Taha, Nadeen M, Ahmed, Muaz, Zeng, Qiudi, Cheuk, Waiyin I, Ip, Bryan, Filo, Elvis, Scott, Brian W, Burnham, W.M, Bazinet, Richard P

“…Abstract Complex partial seizures, which typically originate in limbic structures such as the amygdala, are often resistant to antiseizure medications. Our…”
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Dietary Enrichment with Medium Chain Triglycerides (AC-1203) Elevates Polyunsaturated Fatty Acids in the Parietal Cortex of Aged Dogs: Implications for Treating Age-Related Cognitive Decline by Taha, Ameer Y., Henderson, Samuel T., Burnham, W. M.

“…Dogs demonstrate an age-related cognitive decline, which may be related to a decrease in the concentration of omega-3 polyunsaturated fatty acids ( n -3 PUFA)…”
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Acute administration of docosahexaenoic acid increases resistance to pentylenetetrazol-induced seizures in rats by Taha, Ameer Y, Jeffrey, Melanie A, Taha, Nadeen M.Y, Bala, Saimir, Burnham, W.M

“…Abstract Objective Docosahexaenoic acid (DHA), an omega-3 fatty acid, has been reported to raise seizure thresholds. The purpose of the present study was to…”
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Deoxycorticosterone's anticonvulsant effects in infant rats are blocked by finasteride, but not by indomethacin by Perez-Cruz, Claudia, Likhodii, Sergei, Burnham, W.M.

“…Deoxycorticosterone (DOC) is a steroid hormone that suppresses seizures in both humans and animals. At higher doses, DOC's anticonvulsant actions are…”
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The effect of kindled seizures on the locomotory behavior of long–evans rats by Murphy, Patricia, Burnham, W.M

“…The incidence of attention deficit hyperactivity disorder (ADHD) is higher in children with epilepsy than in the general childhood population. The origin of…”
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Steroid hormones affect limbic afterdischarge thresholds and kindling rates in adult female rats by Edwards, Heather E, Burnham, W.McIntyre, Mendonca, Antonio, Bowlby, Deborah A, MacLusky, Neil J

“…Catamenial epileptics show particular vulnerability to seizures during menstruation and at the time of ovulation, when circulating estradiol (E 2)/progesterone…”
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The impact of corticosteroids on the developing animal by EDWARDS, Heather E, BURNHAM, W. Mcintyre

“…Infants are subjected to both endogenous and exogenous corticosteroids in the pre- and postnatal periods. Stress to the mother before birth, or to the child…”
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Cytogenesis in the adult rat dentate gyrus is increased following kindled seizures but is unaltered in pharmacological models of absence seizures by Scott, B.W, Chan, K.F.Y, Wong, G, Ahmed, M, Chieverton, L, Liu, R.R, Wood, J, Burnham, W.M

“…Abstract The production of new neurons continues throughout adulthood in the dentate gyrus of the hippocampal formation, and is believed to play a role in…”
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Kindled seizures enhance young neuron survival in the adult rat dentate gyrus by Scott, B W, Burnham, W M

“…New neurons continue to be generated throughout adulthood in the dentate gyrus of mammals. This process of neurogenesis is believed to play a role in some…”
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Testosterone and its metabolites affect afterdischarge thresholds and the development of amygdala kindled seizures by Edwards, Heather E., Burnham, W.McIntyre, MacLusky, Neil J.

“…In boys with epilepsy, pubertal increases in seizure frequency may be associated with rising androgen levels. The present study tested the hypothesis that…”
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Intraperitoneal administration of docosahexaenoic acid for 14days increases serum unesterified DHA and seizure latency in the maximal pentylenetetrazol model by Trépanier, Marc-Olivier, Lim, Joonbum, Lai, Terence K.Y., Cho, Hye Jin, Domenichiello, Anthony F., Chen, Chuck T., Taha, Ameer Y., Bazinet, Richard P., Burnham, W.M.

“…Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid (n−3 PUFA) which has been shown to raise seizure thresholds following acute administration…”
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The ketogenic diet causes a reversible decrease in activity level in Long–Evans rats by Murphy, Patricia, Burnham, W.M.

“…Individuals with epilepsy also often exhibit symptoms of attention deficit hyperactivity disorder (ADHD). The ketogenic diet, which is a high fat, low protein,…”
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