Search Results - "Burnett, Deborah L."

Clonal redemption and clonal anergy as mechanisms to balance B cell tolerance and immunity by Burnett, Deborah L., Reed, Joanne H., Christ, Daniel, Goodnow, Christopher C.

“…The adaptive immune system is tasked with producing antibodies that recognize a wide scope of potential pathogens, including those never before encountered,…”
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Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination by Burnett, Deborah L, Langley, David B, Schofield, Peter, Hermes, Jana R, Chan, Tyani D, Jackson, Jennifer, Bourne, Katherine, Reed, Joanne H, Patterson, Kate, Porebski, Benjamin T, Brink, Robert, Christ, Daniel, Goodnow, Christopher C

“…Antibodies have the specificity to differentiate foreign antigens that mimic self antigens, but it remains unclear how such specificity is acquired. In a mouse…”
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B cells in the balance: Offsetting self-reactivity avoidance with protection against foreign by Young, Clara, Lau, Angelica W. Y., Burnett, Deborah L.

“…Antibodies are theoretically limitless in their diversity and specificity to foreign antigens; however they are constrained by the need to avoid binding to…”
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Insights Into the Host Contribution of Endocrine Associated Immune-Related Adverse Events to Immune Checkpoint Inhibition Therapy by Chye, Adrian, Allen, India, Barnet, Megan, Burnett, Deborah L.

“…Blockade of immune checkpoints transformed the paradigm of systemic cancer therapy, enabling substitution of a cytotoxic chemotherapy backbone to one of…”
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Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients by Rouet, Romain, Henry, Jake Y., Johansen, Matt D., Sobti, Meghna, Balachandran, Harikrishnan, Langley, David B., Walker, Gregory J., Lenthall, Helen, Jackson, Jennifer, Ubiparipovic, Stephanie, Mazigi, Ohan, Schofield, Peter, Burnett, Deborah L., Brown, Simon H. J., Martinello, Marianne, Hudson, Bernard, Gilroy, Nicole, Post, Jeffrey J., Kelleher, Anthony, Jäck, Hans-Martin, Goodnow, Christopher C., Turville, Stuart G., Rawlinson, William D., Bull, Rowena A., Stewart, Alastair G., Hansbro, Philip M., Christ, Daniel

“…Emerging variants of concern (VOCs) are threatening to limit the effectiveness of SARS-CoV-2 monoclonal antibodies and vaccines currently used in clinical…”
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Murine LRBA deficiency causes CTLA‐4 deficiency in Tregs without progression to immune dysregulation by Burnett, Deborah L, Parish, Ian A, Masle‐Farquhar, Etienne, Brink, Robert, Goodnow, Christopher C

“…Inherited mutations in lipopolysaccharide‐responsive beige‐like anchor (LRBA) cause a recessive human immune dysregulation syndrome with memory B‐cell and…”
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Editorial: Decoding checkpoint inhibitor-induced endocrinopathies by Burnett, Deborah L., Barnet, Megan B., Samaras, Katherine

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Editorial: Decoding checkpoint inhibitor-induced immune-related adverse events, volume II by Burnett, Deborah L., Barnet, Megan B., Moxon, Ania, Tsang, Venessa, Samaras, Katherine

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Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways by Josefsson, Emma C., Burnett, Deborah L., Lebois, Marion, Debrincat, Marlyse A., White, Michael J., Henley, Katya J., Lane, Rachael M., Moujalled, Diane, Preston, Simon P., O’Reilly, Lorraine A., Pellegrini, Marc, Metcalf, Donald, Strasser, Andreas, Kile, Benjamin T.

“…BH3 mimetic drugs that target BCL-2 family pro-survival proteins to induce tumour cell apoptosis represent a new era in cancer therapy. Clinical trials of…”
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Total recall? Understanding the effect of antigenic distance on original antigenic sin by Burnett, Deborah L, Bull, Rowena A

“…Vaccination‐induced antibodies are critical for protective immunity against pathogenic threats. “Original antigenic sin” (OAS), also referred to as imprinting,…”
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Getting to the (germinal) center of humoral immune responses to SARS-CoV-2 by Tangye, Stuart G., Burnett, Deborah L., Bull, Rowena A.

“…Long-term protection against SARS-CoV-2 requires effective and durable immunity. In this issue of Cell, two papers closely examine germinal centers, the…”
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Blood and guts: peripheral immune correlates of immunotherapy‐induced colitis by Barnet, Megan, Masle‐Farquhar, Etienne, Singh, Mandeep, Burnett, Deborah L

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Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody by Singh, Mandeep, Jackson, Katherine J.L., Wang, Jing J., Schofield, Peter, Field, Matt A., Koppstein, David, Peters, Timothy J., Burnett, Deborah L., Rizzetto, Simone, Nevoltris, Damien, Masle-Farquhar, Etienne, Faulks, Megan L., Russell, Amanda, Gokal, Divya, Hanioka, Asami, Horikawa, Keisuke, Colella, Alexander D., Chataway, Timothy K., Blackburn, James, Mercer, Tim R., Langley, David B., Goodall, D. Margaret, Jefferis, Roy, Gangadharan Komala, Muralikrishna, Kelleher, Anthony D., Suan, Dan, Rischmueller, Maureen, Christ, Daniel, Brink, Robert, Luciani, Fabio, Gordon, Tom P., Goodnow, Christopher C., Reed, Joanne H.

“…Pathogenic autoantibodies arise in many autoimmune diseases, but it is not understood how the cells making them evade immune checkpoints. Here, single-cell…”
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Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability by Burnett, Deborah L., Jackson, Katherine J.L., Langley, David B., Aggarwal, Anupriya, Stella, Alberto Ospina, Johansen, Matt D., Balachandran, Harikrishnan, Lenthall, Helen, Rouet, Romain, Walker, Gregory, Saunders, Bernadette M., Singh, Mandeep, Li, Hui, Henry, Jake Y., Jackson, Jennifer, Stewart, Alastair G., Witthauer, Franka, Spence, Matthew A., Hansbro, Nicole G., Jackson, Colin, Schofield, Peter, Milthorpe, Claire, Martinello, Marianne, Schulz, Sebastian R., Roth, Edith, Kelleher, Anthony, Emery, Sean, Britton, Warwick J., Rawlinson, William D., Karl, Rudolfo, Schäfer, Simon, Winkler, Thomas H., Brink, Robert, Bull, Rowena A., Hansbro, Philip M., Jäck, Hans-Martin, Turville, Stuart, Christ, Daniel, Goodnow, Christopher C.

“…Viral mutations are an emerging concern in reducing SARS-CoV-2 vaccination efficacy. Second-generation vaccines will need to elicit neutralizing antibodies…”
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Augmented neutralization of SARS‐CoV‐2 Omicron variant by boost vaccination and monoclonal antibodies by Schulz, Sebastian R., Hoffmann, Markus, Roth, Edith, Pracht, Katharina, Burnett, Deborah L., Mazigi, Ohan, Schuh, Wolfgang, Manger, Bernhard, Mielenz, Dirk, Goodnow, Christopher C., Christ, Daniel, Pöhlmann, Stefan, Jäck, Hans‐Martin

“…Effective vaccines and monoclonal antibodies have been developed against coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome…”
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Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens by Burnett, Deborah L., Schofield, Peter, Langley, David B., Jackson, Jennifer, Bourne, Katherine, Wilson, Emily, Porebski, Benjamin T., Buckle, Ashley M., Brink, Robert, Goodnow, Christopher C., Christ, Daniel

“…Conformational diversity and self-cross-reactivity of antigens have been correlated with evasion from neutralizing antibody responses. We utilized single cell…”
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The importance of veterinary specialized generalists in biomedical research by Burnett, Deborah L., Bertzbach, Luca D.

“…Given that no transmissible human tumour has been discovered, studying this disease in animals allows for a potential head start to understand a disease…”
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Platform for isolation and characterization of SARS-CoV-2 variants enables rapid characterization of Omicron in Australia by Aggarwal, Anupriya, Stella, Alberto Ospina, Walker, Gregory, Akerman, Anouschka, Esneau, Camille, Milogiannakis, Vanessa, Burnett, Deborah L., McAllery, Samantha, Silva, Mariana Ruiz, Lu, Yonghui, Foster, Charles S. P., Brilot, Fabienne, Pillay, Aleha, Van Hal, Sabastiaan, Mathivanan, Vennila, Fichter, Christina, Kindinger, Andrea, Hoppe, Alexandra Carey, Munier, Mee Ling, Amatayakul-Chantler, Supavadee, Roth, Nathan, Coppola, Germano, Symonds, Geoff P., Schofield, Peter, Jackson, Jennifer, Lenthall, Helen, Henry, Jake Y., Mazigi, Ohan, Jäck, Hans-Martin, Davenport, Miles P., Darley, David R., Matthews, Gail V., Khoury, David S., Cromer, Deborah, Goodnow, Christopher C., Christ, Daniel, Robosa, Roselle, Starck, Damien J., Bartlett, Nathan W., Rawlinson, William D., Kelleher, Anthony D., Turville, Stuart G.

“…Genetically distinct variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged since the start of the COVID-19 pandemic. Over this…”
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Investigation of cell-free DNA in canine plasma and its relation to disease by Burnett, Deborah L., Cave, Nicholas J., Gedye, Kristene R., Bridges, Janis P.

“…Background: DNA is released from dying cells during apoptosis and necrosis. This cell-free DNA (cfDNA) diffuses into the plasma where it can be measured. In…”
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Abstract 665: Correlation between a CTLA-4 single nucleotide polymorphism and high response to anti-PD1/PDL1 immunotherapy in advanced non small cell lung cancer by Allen, India A., Russell, Amanda, Jackson, Katherine J., Peters, Timothy, Gibson, Greg, Joshua, Anthony M., Goodnow, Christopher C., Burnett, Deborah L., Barnet, Megan B.

“…Abstract Blockade of the immune checkpoint protein Programmed Cell Death Protein-1 or its ligand (PD-1 and PD-L1, respectively) allows durable cancer control…”
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