Search Results - "Burnet, N G"

Guidelines for preclinical and early phase clinical assessment of novel radiosensitisers by Harrington, K J, Billingham, L J, Brunner, T B, Burnet, N G, Chan, C S, Hoskin, P, Mackay, R I, Maughan, T S, Macdougall, J, McKenna, W G, Nutting, C M, Oliver, A, Plummer, R, Stratford, I J, Illidge, T

Get full text

Years of life lost (YLL) from cancer is an important measure of population burden - and should be considered when allocating research funds by BURNET, N. G, JEFFERIES, S. J, BENSON, R. J, HUNT, D. P, TREASURE, F. P

“…Recently, cancer mortality has been compared to research spending by the National Cancer Research Institute (NCRI), whose research budget is approximately…”
Get full text

Improved Delineation of Glioma Margins and Regions of Infiltration with the Use of Diffusion Tensor Imaging: An Image-Guided Biopsy Study by Price, S.J, Jena, R, Burnet, N.G, Hutchinson, P.J, Dean, A.F, Pena, A, Pickard, J.D, Carpenter, T.A, Gillard, J.H

“…The efficacy of radiation therapy, the mainstay of treatment for malignant gliomas, is limited by our inability to accurately determine tumor margins. As a…”
Get full text

Clinically relevant nanodosimetric simulation of DNA damage complexity from photons and protons by Henthorn, N T, Warmenhoven, J W, Sotiropoulos, M, Aitkenhead, A H, Smith, E A K, Ingram, S P, Kirkby, N F, Chadwick, A L, Burnet, N G, Mackay, R I, Kirkby, K J, Merchant, M J

“…Relative Biological Effectiveness (RBE), the ratio of doses between radiation modalities to produce the same biological endpoint, is a controversial and…”
Get full text

A replicated association between polymorphisms near TNFα and risk for adverse reactions to radiotherapy by Talbot, C J, Tanteles, G A, Barnett, G C, Burnet, N G, Chang-Claude, J, Coles, C E, Davidson, S, Dunning, A M, Mills, J, Murray, R J S, Popanda, O, Seibold, P, West, C M L, Yarnold, J R, Symonds, R P

“…Background: Response to radiotherapy varies between individuals both in terms of efficacy and adverse reactions. Finding genetic determinants of radiation…”
Get full text

A novel algorithm for the morphometric assessment of radiotherapy treatment planning volumes by JENA, R, KIRKBY, N. F, BURTON, K. E, HOOLE, A. C. F, TAN, L. T, BURNET, N. G

“…Quantitative assessment of target volume contouring in radiotherapy treatment planning is an important aspect of quality assessment and educational exercises…”
Get full text

Temozolomide responsiveness in aggressive corticotroph tumours: a case report and review of the literature by Annamalai, A. K., Dean, A. F., Kandasamy, N., Kovacs, K., Burton, H., Halsall, D. J., Shaw, A. S., Antoun, N. M., Cheow, H. K., Kirollos, R. W., Pickard, J. D., Simpson, H. L., Jefferies, S. J., Burnet, N. G., Gurnell, M.

“…Pituitary carcinoma occurs in ~0.2% of resected pituitary tumours and carries a poor prognosis (mean survival <4 years), with standard chemotherapy regimens…”
Get full text

Imaging regional variation of cellular proliferation in gliomas using 3′-deoxy-3′-[18 F]fluorothymidine positron-emission tomography: an image-guided biopsy study by Price, S.J, Fryer, T.D, Cleij, M.C, Dean, A.F, Joseph, J, Salvador, R, Wang, D.D, Hutchinson, P.J, Clark, J.C, Burnet, N.G, Pickard, J.D, Aigbirhio, F.I, Gillard, J.H

“…Aim To compare regional variations in uptake of 3′-deoxy-3′- [18 F]-fluorothymidine (FLT) images using positron-emission tomography (PET) with measures of…”
Get full text

Treatment planning optimisation in proton therapy by McGowan, S E, Burnet, N G, Lomax, A J

“…The goal of radiotherapy is to achieve uniform target coverage while sparing normal tissue. In proton therapy, the same sources of geometric uncertainty are…”
Get full text

Diffusion Tensor Imaging of Brain Tumours at 3 T: A Potential Tool for Assessing White Matter Tract Invasion? by Price, S.J., Burnet, N.G., Donovan, T., Green, H.A.L., Peña, A., Antoun, N.M., Pickard, J.D., Carpenter, T.A., Gillard, J.H.

“…AIM: To determine whether diffusion tensor imaging (DTI) of brain tumours can demonstrate abnormalities distal to hyperintensities on T2-weighted images, and…”
Get full text

Assessing Equity of Access to Proton Beam Therapy: A Literature Review by Gaito, S., Aznar, M.C., Burnet, N.G., Crellin, A., France, A., Indelicato, D., Kirkby, K.J., Pan, S., Whitfield, G., Smith, E.

“…Proton beam therapy (PBT) is one of the most advanced radiotherapy technologies, with growing evidence to support its use in specific clinical scenarios and…”
Get full text

Effect of Race and Ethnicity on Risk of Radiotherapy Toxicity and Implications for Radiogenomics by Abdelkarem, O A I, Choudhury, A, Burnet, N G, Summersgill, H R, West, C M L

“…Patient factors affect the risk of radiotherapy toxicity, but many are poorly defined. Studies have shown that race affects cancer incidence, survival, drug…”
Get full text

A Novel Model and Infrastructure for Clinical Outcomes Data Collection and Their Systematic Evaluation for UK Patients Receiving Proton Beam Therapy by Hwang, E., Burnet, N.G., Crellin, A.M., Ahern, V., Thwaites, D.I., Gaito, S., Chang, Y.-C., Smith, E.

“…To establish an infrastructure for sustainable, comprehensive data collection and systematic outcomes evaluation for UK patients receiving proton beam therapy…”
Get full text

Proton Beam Therapy in the Reirradiation Setting of Brain and Base of Skull Tumour Recurrences by Gaito, S., Burnet, N.G., Aznar, M.C., Marvaso, G., Jereczek-Fossa, B.A., Crellin, A., Indelicato, D., Pan, S., Colaco, R., Rieu, R., Smith, E., Whitfield, G.

“…The therapeutic management of local tumour recurrence after a first course of radical radiotherapy is always complex. Surgery and reirradiation carry increased…”
Get full text

Mechanistic modelling supports entwined rather than exclusively competitive DNA double-strand break repair pathway by Ingram, S. P., Warmenhoven, J. W., Henthorn, N. T., Smith, E. A. K., Chadwick, A. L., Burnet, N. G., Mackay, R. I., Kirkby, N. F., Kirkby, K. J., Merchant, M. J.

“…Following radiation induced DNA damage, several repair pathways are activated to help preserve genome integrity. Double Strand Breaks (DSBs), which are highly…”
Get full text

Delivered dose can be a better predictor of rectal toxicity than planned dose in prostate radiotherapy by Shelley, L.E.A, Scaife, J.E, Romanchikova, M, Harrison, K, Forman, J.R, Bates, A.M, Noble, D.J, Jena, R, Parker, M.A, Sutcliffe, M.P.F, Thomas, S.J, Burnet, N.G

“…Abstract Background and purpose For the first time, delivered dose to the rectum has been calculated and accumulated throughout the course of prostate…”
Get full text

Comparing Proton to Photon Radiotherapy Plans: UK Consensus Guidance for Reporting Under Uncertainty for Clinical Trials by Lowe, M., Gosling, A., Nicholas, O., Underwood, T., Miles, E., Chang, Y.-C., Amos, R.A., Burnet, N.G., Clark, C.H., Patel, I., Tsang, Y., Sisson, N., Gulliford, S.

“…In the UK, the recent introduction of high-energy proton beam therapy into national clinical practice provides an opportunity for new clinical trials,…”
Get full text

Re-irradiation: From Cell Lines to Patients, Filling the (Science) Gap in the Market by Murray, L.J., Appelt, A.L., Ajithkumar, T., Bedford, J.L., Burnet, N.G., Lalondrelle, S., Manolopoulos, S., O'Cathail, S.M., Robinson, M., Short, S.C., Slevin, F., Thomson, D.J.

Get full text

Tumour Volume and Dose Influence Outcome after Surgery and High-dose Photon Radiotherapy for Chordoma and Chondrosarcoma of the Skull Base and Spine by Gatfield, E.R., Noble, D.J., Barnett, G.C., Early, N.Y., Hoole, A.C.F., Kirkby, N.F., Jefferies, S.J., Burnet, N.G.

“…To evaluate the long-term outcomes of patients with chordoma and low-grade chondrosarcoma after surgery and high-dose radiotherapy. High-dose photon…”
Get full text

Exploiting biological and physical determinants of radiotherapy toxicity to individualize treatment by Scaife, J E, Barnett, G C, Noble, D J, Jena, R, Thomas, S J, West, C M L, Burnet, N G

“…The recent advances in radiation delivery can improve tumour control probability (TCP) and reduce treatment-related toxicity. The use of intensity-modulated…”
Get full text