Search Results - "Burnand, Kevin G."

Galectin-3 Is an Amplifier of Inflammation in Atherosclerotic Plaque Progression Through Macrophage Activation And Monocyte Chemoattraction by Papaspyridonos, Marianna, McNeill, Eileen, de Bono, Joe P, Smith, Alberto, Burnand, Kevin G, Channon, Keith M, Greaves, David R

“…OBJECTIVE—Galectin-3 (Gal-3) is a 26-kDa lectin known to regulate many aspects of inflammatory cell behavior. We assessed the hypothesis that increased levels…”
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Novel Candidate Genes in Unstable Areas of Human Atherosclerotic Plaques by Papaspyridonos, Marianna, Smith, Alberto, Burnand, Kevin G, Taylor, Peter, Padayachee, Soundrie, Suckling, Keith E, James, Christian H, Greaves, David R, Patel, Lisa

“…OBJECTIVE—Comparison of gene expression in stable versus unstable atherosclerotic plaque may be confounded by interpatient variability. The aim of this study…”
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Electrospray Ionization Mass Spectrometry Identifies Substrates and Products of Lipoprotein-associated Phospholipase A2 in Oxidized Human Low Density Lipoprotein by Davis, Bill, Koster, Grielof, Douet, Lisa J., Scigelova, Michaela, Woffendin, Gary, Ward, Joanna M., Smith, Alberto, Humphries, Julia, Burnand, Kevin G., Macphee, Colin H., Postle, Anthony D.

“…There is increasing evidence that modified phospholipid products of low density lipoprotein (LDL) oxidation mediate inflammatory processes within vulnerable…”
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The monocyte/macrophage as a therapeutic target in atherosclerosis by Saha, Prakash, Modarai, Bijan, Humphries, Julia, Mattock, Katherine, Waltham, Matthew, Burnand, Kevin G, Smith, Alberto

“…It is now clear that the monocyte/macrophage has a crucial role in the development of atherosclerosis. This cell appears to be involved in all stages of…”
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Cysteine protease activity in the wall of abdominal aortic aneurysms by Abisi, Said, MRCS, Burnand, Kevin G., FRCS, MS, Waltham, Matthew, FRCS, PhD, Humphries, Julia, PhD, Taylor, Peter R., FRCS, MS, Smith, Alberto, PhD

“…Background Cysteine proteases are potent elastolytic enzymes and together with their inhibitor, cystatin C, have been linked with the growth of abdominal…”
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Monocyte urokinase-type plasminogen activator up-regulation reduces thrombus size in a model of venous thrombosis by Humphries, Julia, PhD, Gossage, James A., MS, MRCS, Modarai, Bijan, MRCS, PhD, Burnand, Kevin G., MS, FRCS, Sisson, Thomas H., MD, Murdoch, Colin, PhD, Smith, Alberto, PhD

“…Background Our previous studies showed that the direct injection of an adenovirus construct expressing urokinase-type plasminogen activator (uPA) into…”
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Stromelysin-1 (matrix metalloproteinase-3) and tissue inhibitor of metalloproteinase-3 are overexpressed in the wall of abdominal aortic aneurysms by CARRELL, Tom W. G, BURNAND, Kevin G, WELLS, Graham M. A, CLEMENTS, John M, SMITH, Alberto

“…Atherosclerosis is implicated in the pathogenesis of abdominal aortic aneurysm (AAA) but more often causes aortic occlusive disease (AOD). The matrix…”
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Mutations in FOXC2 in humans (lymphoedema distichiasis syndrome) cause lymphatic dysfunction on dependency by Mellor, Russell H, Tate, Naomi, Stanton, Anthony W B, Hubert, Charlotte, Mäkinen, Taija, Smith, Alberto, Burnand, Kevin G, Jeffery, Steve, Levick, J Rodney, Mortimer, Peter S

“…Human lymphoedema distichiasis syndrome (LDS) results from germline mutations in transcription factor FOXC2. In a mouse model, lack of lymphatic and venous…”
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Human tribbles homologue 2 is expressed in unstable regions of carotid plaques and regulates macrophage IL-10 in vitro by Deng, Jingti, James, Christian H, Patel, Lisa, Smith, Alberto, Burnand, Kevin G, Rahmoune, Hassan, Lamb, Jonathan R, Davis, Bill

“…Mammalian orthologues of the Drosophila tribbles protein (Trb1, Trb2 and Trb3) are a recently described family of signalling molecules that regulate gene…”
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Increased but ineffectual angiogenic drive in nonhealing venous leg ulcers by Drinkwater, Susan L, Burnand, Kevin G, Ding, Ren, Smith, Alberto

“…Our previous work demonstrated that angiogenesis is inhibited in nonhealing venous ulcers. The object of this study was to determine whether local expression…”
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Vascular endothelial growth factor enhances venous thrombus recanalisation and organisation by Waltham, Matthew, Burnand, Kevin G, Collins, Michael, McGuinness, Catharine L, Singh, Inderjit, Smith, Alberto

“…Vascular endothelial growth factor (VEGF) is a regulator of physiological and pathological angiogenesis and is found in naturally resolving experimental venous…”
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Mutations in FOXC2 are strongly associated with primary valve failure in veins of the lower limb by MELLOR, Russell H, BRICE, Glen, STANTON, Anthony W. B, FRENCH, Jane, SMITH, Alberto, JEFFERY, Steve, LEVICK, J. Rodney, BURNAND, Kevin G, MORTIMER, Peter S

“…Mutations in the FOXC2 gene cause lymphedema distichiasis, an inherited primary lymphedema in which a significant number of patients have varicose veins…”
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Nox Activator 1: A Potential Target for Modulation of Vascular Reactive Oxygen Species in Atherosclerotic Arteries by NIU, Xi-Lin, MADAMANCHI, Nageswara R, BURNAND, Kevin G, RUNGE, Marschall S, VENDROV, Aleksandr E, TCHIVILEV, Igor, ROJAS, Mauricio, MADAMANCHI, Chaitanya, BRANDES, Ralph P, KRAUSE, Karl-Heinz, HUMPHRIES, Julia, SMITH, Alberto

“…Despite a concerted effort by many laboratories, the critical subunits that participate in vascular smooth muscle cell (VSMC) NADPH oxidase function have yet…”
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A decade of experience with dorsalis pedis artery bypass: Analysis of outcome in more than 1000 cases by Pomposelli, Frank B., Kansal, Nikhil, Hamdan, Alan D., Belfield, Alana, Sheahan, Malachi, Campbell, David R., Skillman, John J., Logerfo, Frank W.

“…Objective: The purpose of this study was to review our experience over the last decade with the dorsalis pedis bypass for ischemic limb salvage in patients…”
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Lymphatic Dysfunction, Not Aplasia, Underlies Milroy Disease by Mellor, Russell H., Hubert, Charlotte E., Stanton, Anthony W.B., Tate, Naomi, Akhras, Victoria, Smith, Alberto, Burnand, Kevin G., Jeffery, Steve, Mäkinen, Taija, Levick, J. Rodney, Mortimer, Peter S.

“…Microcirculation (2010) 17, 281–296. doi: 10.1111/j.1549‐8719.2010.00030.x Objective:  Milroy disease is an inherited autosomal dominant lymphoedema caused by…”
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Hematopoietic Progenitor Cells and Restenosis After Carotid Endarterectomy by PATEL, Sanjay D, HUMPHRIES, Julia, MATTOCK, Katherine, WADOODI, Ashar, MODARAI, Bijan, AHMAD, Anwar, BURNAND, Kevin G, WALTHAM, Matthew, SMITH, Alberto

“…Hematopoietic progenitor cells (HPCs) may attenuate the response to vascular injury by maintaining endothelial integrity and function. Our aim was to determine…”
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Adenoviral urokinase-type plasminogen activator (uPA) gene transfer enhances venous thrombus resolution by Gossage, James A., Humphries, Julia, Modarai, Bijan, Burnand, Kevin G., Smith, Alberto

“…There is an increase in the natural level of urokinase-type plasminogen activator (uPA) activity within the thrombus during venous thrombus resolution. The use…”
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An increased frequency of the 5A allele in the promoter region of the MMP3 gene is associated with abdominal aortic aneurysms by Deguara, Jean, Burnand, Kevin G., Berg, Jonathan, Green, Peter, Lewis, Cathryn M., Chinien, Ganesh, Waltham, Matthew, Taylor, Peter, Stern, Rachel F., Solomon, Ellen, Smith, Alberto

“…Matrix metalloproteinase 3 (MMP3), is over expressed in the wall of abdominal aortic aneurysms (AAA), while inactivation of the gene expressing this enzyme is…”
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Identification of potentially effective antisense oligodeoxyribonucleotide (ODN) sequences for inhibiting plasminogen activator inhibitor-2 (PAI-2) production by monocytes by Humphries, Julia, Burnand, Kevin G, Cunningham, Philip, Brock, Adrian, Westwood, Nigel, Smith, Alberto

“…Monocyte fibrinolytic activity may influence thrombus resolution. The balance between uPA and PAI-2 could determine the fibrinolytic activity of the monocyte…”
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Complications After Endoluminal Stent Grafting of a Thoracic Mycotic Aneurysm by SAHA, Prakash, BURNAND, Kevin G, PATEL, Sanjay D, WALTHAM, Matt

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