Melanins of Inonotus Obliquus : Bifidogenic and Antioxidant Properties

Extracts and melanins from are widely used in medicine due to their high antioxidant properties. This study is dedicated to define the influence of the physicochemical and antioxidant properties of melanins and their bifidogenic effects on 1 and For this purpose, melanins precipitated from aqueous e...

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Bibliographic Details
Published in:	Biomolecules (Basel, Switzerland) Vol. 9; no. 6; p. 248
Main Authors:	Burmasova, Marina A, Utebaeva, Aidana A, Sysoeva, Elena V, Sysoeva, Maria A
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI 24-06-2019 MDPI AG
Subjects:	antioxidant activity Antioxidants - chemistry Antioxidants - isolation & purification Antioxidants - pharmacology Basidiomycota - chemistry bifidobacteria Bifidobacterium bifidum - drug effects Bifidobacterium bifidum - growth & development bifidogenic Chemical Phenomena Dose-Response Relationship, Drug Inonotus obliquus melanins Melanins - chemistry Melanins - isolation & purification Melanins - pharmacology Inonotus obliquus bifidobacteria bifidogenic antioxidant activity melanins
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Summary:	Extracts and melanins from are widely used in medicine due to their high antioxidant properties. This study is dedicated to define the influence of the physicochemical and antioxidant properties of melanins and their bifidogenic effects on 1 and For this purpose, melanins precipitated from aqueous extracts, obtained by a few methods, and separated melanin fractions by organic solvents were used. For the melanin physicochemical properties analysis spectrophotometry, electron paramagnetic resonance (EPR) spectroscopy and dynamic light scattering methods were applied. Melanins and their fractions difference in particle size and charge, antioxidant properties, and redox potential were revealed. It was shown that the redox potential, the size of melanin particles and the z-potential had maximum influence on bifidobacteria growth. The greatest activating effect on bifidobacteria was established by using melanin isolated from aqueous microwave extracts in concentrations of 10 , 10 , 10 g/cm . The use of this melanin with antioxidant activity 0.67 ± 0.06 mg/g (expressed as ascorbic acid equivalent), and with redox potential -5.51 ± 2.22 mV as a prebiotic allowed the growth of 1 s to increase by 1.4 times in comparison with ascorbic acid by 24 h of cultivation.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2218-273X 2218-273X
DOI:	10.3390/biom9060248