Search Results - "Burm, Saskia"

Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo by Oosterhof, Nynke, Kuil, Laura E., van der Linde, Herma C., Burm, Saskia M., Berdowski, Woutje, van Ijcken, Wilfred F.J., van Swieten, John C., Hol, Elly M., Verheijen, Mark H.G., van Ham, Tjakko J.

“…Microglia are brain-resident macrophages with trophic and phagocytic functions. Dominant loss-of-function mutations in a key microglia regulator,…”
Get full text

VISTA expression by microglia decreases during inflammation and is differentially regulated in CNS diseases by Borggrewe, Malte, Grit, Corien, Den Dunnen, Wilfred F. A., Burm, Saskia M., Bajramovic, Jeffrey J., Noelle, Randolph J., Eggen, Bart J. L., Laman, Jon D.

“…V‐type immunoglobulin domain‐containing suppressor of T‐cell activation (VISTA) is a negative checkpoint regulator (NCR) involved in inhibition of T…”
Get full text

An Overview of in vitro Methods to Study Microglia by Timmerman, Raissa, Burm, Saskia M, Bajramovic, Jeffrey J

“…Neuroinflammation is a common feature in neurodegenerative diseases and strategies to modulate neuroinflammatory processes are increasingly considered as…”
Get full text

Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors by Muik, Alexander, Garralda, Elena, Altintas, Isil, Gieseke, Friederike, Geva, Ravit, Ben-Ami, Eytan, Maurice-Dror, Corinne, Calvo, Emiliano, LoRusso, Patricia M, Alonso, Guzman, Rodriguez-Ruiz, Maria E, Schoedel, Kristina B, Blum, Jordan M, Sänger, Bianca, Salcedo, Theodora W, Burm, Saskia M, Stanganello, Eliana, Verzijl, Dennis, Vascotto, Fulvia, Sette, Angelica, Quinkhardt, Juliane, Plantinga, Theo S, Toker, Aras, van den Brink, Edward N, Fereshteh, Mark, Diken, Mustafa, Satijn, David, Kreiter, Sebastian, Breij, Esther C W, Bajaj, Gaurav, Lagkadinou, Eleni, Sasser, Kate, Türeci, Özlem, Forssmann, Ulf, Ahmadi, Tahamtan, Şahin, Uğur, Jure-Kunkel, Maria, Melero, Ignacio

“…Checkpoint inhibitors (CPI) have revolutionized the treatment paradigm for advanced solid tumors; however, there remains an opportunity to improve response…”
Get more information

Inflammasome-induced IL-1β secretion in microglia is characterized by delayed kinetics and is only partially dependent on inflammatory caspases by Burm, Saskia M, Zuiderwijk-Sick, Ella A, 't Jong, Anke E J, van der Putten, Céline, Veth, Jennifer, Kondova, Ivanela, Bajramovic, Jeffrey J

“…Inflammasomes are multiprotein complexes that link pathogen recognition and cellular stress to the processing of the proinflammatory cytokine interleukin-1β…”
Get full text

Transcriptome analysis reveals the contribution of oligodendrocyte and radial glia‐derived cues for maintenance of microglia identity by Timmerman, Raissa, Zuiderwijk‐Sick, Ella A., Oosterhof, Nynke, 't Jong, Anke E. J., Veth, Jennifer, Burm, Saskia M., Ham, Tjakko J., Bajramovic, Jeffrey J.

“…Microglia are increasingly being recognized as druggable targets in neurodegenerative disorders, and good in vitro models are crucial to address cell…”
Get full text

An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation by Muik, Alexander, Altintas, Isil, Gieseke, Friederike, Schoedel, Kristina B, Burm, Saskia M, Toker, Aras, Salcedo, Theodora W., Verzijl, Dennis, Eisel, David, Grunwitz, Christian, Kranz, Lena M, Vormehr, Mathias, Satijn, David P.E., Diken, Mustafa, Kreiter, Sebastian, Sasser, Kate, Ahmadi, Tahamtan, Türeci, Özlem, Breij, Esther C.W., Jure-Kunkel, Maria, Sahin, Ugur

“…Immune checkpoint inhibitors (ICI) targeting the PD-1/PD-L1 axis have changed the treatment paradigm for advanced solid tumors; however, many patients…”
Get full text

DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity by Muik, Alexander, Adams III, Homer C, Gieseke, Friederike, Altintas, Isil, Schoedel, Kristina B, Blum, Jordan M, Sänger, Bianca, Burm, Saskia M, Stanganello, Eliana, Verzijl, Dennis, Spires, Vanessa M, Vascotto, Fulvia, Toker, Aras, Quinkhardt, Juliane, Fereshteh, Mark, Diken, Mustafa, Satijn, David P E, Kreiter, Sebastian, Ahmadi, Tahamtan, Breij, Esther C W, Türeci, Özlem, Sasser, Kate, Sahin, Ugur, Jure-Kunkel, Maria

“…BackgroundDespite the preclinical promise of CD40 and 4-1BB as immuno-oncology targets, clinical efforts evaluating CD40 and 4-1BB agonists as monotherapy have…”
Get full text

Transcriptome and proteome profiling of neural stem cells from the human subventricular zone in Parkinson's disease by Donega, Vanessa, Burm, Saskia M, van Strien, Miriam E, van Bodegraven, Emma J, Paliukhovich, Iryna, Geut, Hanneke, van de Berg, Wilma D J, Li, Ka Wan, Smit, August B, Basak, Onur, Hol, Elly M

“…It is currently accepted that the human brain has a limited neurogenic capacity and an impaired regenerative potential. We have previously shown the existence…”
Get full text

TLR-Induced IL-12 and CCL2 Production by Myeloid Cells Is Dependent on Adenosine A3 Receptor–Mediated Signaling by van der Putten, Céline, Veth, Jennifer, Sukurova, Lejla, Zuiderwijk-Sick, Ella A., Simonetti, Elles, Koenen, Hans J. P .M., Burm, Saskia M., van Noort, Johannes M., IJzerman, Ad P., van Hijum, Sacha A. F. T., Diavatopoulos, Dimitri, Bajramovic, Jeffrey J.

“…Abstract TLR-induced signaling potently activates cells of the innate immune system and is subject to regulation at different levels. Inflammatory conditions…”
Get full text

Systematic study of tissue factor expression in solid tumors by Bono, Johann S., Harris, Jeffrey R., Burm, Saskia M., Vanderstichele, Adriaan, Houtkamp, Mischa A., Aarass, Saida, Riisnaes, Ruth, Figueiredo, Ines, Nava Rodrigues, Daniel, Christova, Rossitza, Olbrecht, Siel, Niessen, Hans W. M., Ruuls, Sigrid R., Schuurhuis, Danita H., Lammerts van Bueren, Jeroen J., Breij, Esther C. W., Vergote, Ignace

“…Background Elevated tissue factor (TF) expression, although restricted in normal tissue, has been reported in multiple solid cancers, and expression has been…”
Get full text

Mechanistic and pharmacodynamic studies of DuoBody-CD3x5T4 in preclinical tumor models by Kemper, Kristel, Gielen, Ellis, Boross, Peter, Houtkamp, Mischa, Plantinga, Theo S, de Poot, Stefanie Ah, Burm, Saskia M, Janmaat, Maarten L, Koopman, Louise A, van den Brink, Edward N, Rademaker, Rik, Verzijl, Dennis, Engelberts, Patrick J, Satijn, David, Sasser, A Kate, Breij, Esther Cw

“…CD3 bispecific antibodies (bsAbs) show great promise as anticancer therapeutics. Here, we show in-depth mechanistic studies of a CD3 bsAb in solid cancer,…”
Get full text

Alternative methods for the use of non-human primates in biomedical research by Burm, Saskia M, Prins, Jan-Bas, Langermans, Jan, Bajramovic, Jeffrey J

“…The experimental use of non-human primates (NHP) in Europe is tightly regulated and is only permitted when there are no alternatives available. As a result,…”
Get full text

561 DuoBody®-PD-L1×4–1BB (GEN1046) induces superior immune-cell activation, cytokine production and cytotoxicity by combining PD-L1 blockade with conditional 4–1BB co-stimulation by Muik, Alexander, Altintas, Isil, Kosoff, Rachelle, Gieseke, Friederike, Schödel, Kristina, Salcedo, Theodora, Burm, Saskia, Toker, Aras, Kranz, Lena, Vormehr, Mathias, Eisel, David, Fereshteh, Mark, Türeci, Özlem, Breij, Esther, Ahmadi, Tahamtan, Sahin, Ugur, Jure-Kunkel, Maria

“…BackgroundCheckpoint inhibitors targeting the PD-1/PD-L1 axis (CPI) have changed the treatment paradigm and prognosis for patients with advanced solid tumors;…”
Get full text

ATP-induced IL-1β secretion is selectively impaired in microglia as compared to hematopoietic macrophages by Burm, Saskia Maria, Zuiderwijk-Sick, Ella Alwine, Weert, Paola Massiel, Bajramovic, Jeffrey John

“…Under stressful conditions nucleotides are released from dying cells into the extracellular space, where they can bind to purinergic P2X and P2Y receptors…”
Get full text

Expression of IL-1β in rhesus EAE and MS lesions is mainly induced in the CNS itself by Burm, Saskia Maria, Peferoen, Laura Anna Norma, Zuiderwijk-Sick, Ella Alwine, Haanstra, Krista Geraldine, 't Hart, Bert Adriaan, van der Valk, Paul, Amor, Sandra, Bauer, Jan, Bajramovic, Jeffrey John

“…Interleukin (IL)-1β is a pro-inflammatory cytokine that plays a role in the pathogenesis of multiple sclerosis (MS) and experimental autoimmune…”
Get full text

Abstract 1846: DuoBody-CD40×4-1BB (GEN1042) induces dendritic-cell maturation and enhances T-cell activation and effector functions in vitro by conditional CD40 and 4-1BB agonist activity by Muik, Alexander, Kosoff, Rachelle, Gieseke, Friederike, Altintas, Isil, Schödel, Kristina, Burm, Saskia, Stanganello, Eliana, Vascotto, Fulvia, Toker, Aras, Adams, Homer, Breij, Esther, Diken, Mustafa, Ahmadi, Tahamtan, Sasser, Kate, Türeci, Özlem, Fereshteh, Mark, Sahin, Ugur, Jure-Kunkel, Maria

“…Abstract The clinical success of immune checkpoint inhibitor monoclonal antibodies (mAbs) has demonstrated potential for re-activation of anti-tumor immunity…”
Get full text

ATP-induced IL-1[beta] secretion is selectively impaired in microglia as compared to hematopoietic macrophages by Burm, Saskia Maria, Zuiderwijk-Sick, Ella Alwine, Weert, Paola Massiel, Bajramovic, Jeffrey John

“…Under stressful conditions nucleotides are released from dying cells into the extracellular space, where they can bind to purinergic P2X and P2Y receptors…”
Get full text

ATP-induced IL-1β secretion is selectively impaired in microglia as compared to hematopoietic macrophages: Microglial Adaptation of Innate Immune Responses by Burm, Saskia Maria, Zuiderwijk-Sick, Ella Alwine, Weert, Paola Massiel, Bajramovic, Jeffrey John

Get full text

1208 DuoBody®-PD-L1x4–1BB (GEN1046) reverses T-cell exhaustion in vitro by Blum, Jordan, Spires, Vanessa, Masters, Gregg, Yu, Christina, Burm, Saskia, Hancock, Matt, Jabado, Omar, Higgs, Brandon, Muik, Alexander, Nuermberger, Kristina, Gieseke, Friederike, Ahmadi, Tahamtan, Sasser, Kate, Tureci, Ozlem, Jure-Kunkel, Maria, Sahin, Ugur, Fereshteh, Mark, Pencheva, Nora

“…BackgroundDuoBody®-PD-L1x4-1BB (GEN1046) is an investigational, potential first-in-class bispecific immunomodulatory antibody designed to elicit an anti-tumor…”
Get full text