Search Results - "Burlingame, Mark A."

Turning a protein kinase on or off from a single allosteric site via disulfide trapping by Sadowsky, Jack D, Burlingame, Mark A, Wolan, Dennis W, McClendon, Christopher L, Jacobson, Matthew P, Wells, James A

“…There is significant interest in identifying and characterizing allosteric sites in enzymes such as protein kinases both for understanding allosteric…”
Get full text

Capture of micrococcin biosynthetic intermediates reveals C-terminal processing as an obligatory step for in vivo maturation by Bewley, Kathryn D., Bennallack, Philip R., Burlingame, Mark A., Robison, Richard A., Griffitts, Joel S., Miller, Susan M.

“…Thiopeptides, including micrococcins, are a growing family of bioactive natural products that are ribosomally synthesized and heavily modified. Here we use a…”
Get full text

Reconstitution and Minimization of a Micrococcin Biosynthetic Pathway in Bacillus subtilis by Bennallack, Philip R, Bewley, Kathryn D, Burlingame, Mark A, Robison, Richard A, Miller, Susan M, Griffitts, Joel S

“…Thiopeptides represent one of several families of highly modified peptide antibiotics that hold great promise for natural product engineering. These…”
Get full text

Identification and Optimization of Thienopyridine Carboxamides as Inhibitors of HIV Regulatory Complexes by Nakamura, Robert L, Burlingame, Mark A, Yang, Shumin, Crosby, David C, Talbot, Dale J, Chui, Kitty, Frankel, Alan D, Renslo, Adam R

“…Viral regulatory complexes perform critical functions during virus replication and are important targets for therapeutic intervention. In HIV, the Tat and Rev…”
Get full text

Simple One-Pot Synthesis of Disulfide Fragments for Use in Disulfide-Exchange Screening by Burlingame, Mark A, Tom, Christopher T. M. B, Renslo, Adam R

“…Disulfide exchange screening is a method for evaluating the binding of small molecule fragments to proteins that have at least one accessible cysteine. While…”
Get full text

Toward Understanding How the Lactone Moiety of Discodermolide Affects Activity by Shaw, Simon J, Sundermann, Kurt F, Burlingame, Mark A, Myles, David C, Freeze, B. Scott, Xian, Ming, Brouard, Ignacio, Smith, Amos B

“…A series of simplified discodermolide analogues have been designed and synthesized in an attempt to understand the role of the lactone ring. These synthetic…”
Get full text

Structure−Activity Relationships of 9-Substituted-9-Dihydroerythromycin-Based Motilin Agonists: Optimizing for Potency and Safety by Shaw, Simon J, Chen, Yue, Zheng, Hao, Fu, Hong, Burlingame, Mark A, Marquez, Saul, Li, Yong, Claypool, Mark, Carreras, Christopher W, Crumb, William, Hardy, Dwight J, Myles, David C, Liu, Yaoquan

“…A series of 9-dihydro-9-acetamido-N-desmethyl-N-isopropyl erythromycin A analogues and related derivatives was generated as motilin agonists. The compounds…”
Get full text

Design, Synthesis, and Evaluation of Carbamate-Substituted Analogues of (+)-Discodermolide by Smith, Amos B, Freeze, B. Scott, LaMarche, Matthew J, Hirose, Tomoyasu, Brouard, Ignacio, Rucker, Paul V, Xian, Ming, Sundermann, Kurt F, Shaw, Simon J, Burlingame, Mark A, Horwitz, Susan Band, Myles, David C

“…The design, syntheses, and biological evaluation of 22 totally synthetic analogues of the potent microtubule-stabilizing agent (+)-discodermolide (1) have been…”
Get full text

Design, Synthesis, and Evaluation of Analogues of (+)-14-Normethyldiscodermolide by Smith, Amos B, Freeze, B. Scott, LaMarche, Matthew J, Hirose, Tomoyasu, Brouard, Ignacio, Xian, Ming, Sundermann, Kurt F, Shaw, Simon J, Burlingame, Mark A, Horwitz, Susan Band, Myles, David C

“…The design, syntheses, and biological evaluation of nine totally synthetic analogues of the microtubule-stabilizing agent (+)-14-normethyldiscodermolide (2)…”
Get full text

A series of 23,24-dihydrodiscodermolide analogues with simplified lactone regions by Shaw, Simon J., Sundermann, Kurt F., Burlingame, Mark A., Zhang, Dan, Petryka, Joseph, Myles, David C.

“…A collection of seven new 23,24-dihydrodiscodermolide analogues have been synthesized with modifications to the lactone ring, some of which show…”
Get full text

Design, synthesis and cytotoxicity of 7-deoxy aryl discodermolide analogues by BURLINGAME, Mark A, SHAW, Simon J, FREEZE, B. Scott, SMITH, Amos B, SUNDERMANN, Kurt F, DAN ZHANG, PETRYKA, Joseph, MENDOZA, Esteban, FENGHUA LIU, MYLES, David C, LAMARCHE, Matthew J, HIROSE, Tomoyasu

“…A series of 7-deoxy discodermolide analogues in which the lactone fragment 'C' was replaced by aryl substituents were designed, synthesized, and evaluated for…”
Get full text

Synthesis of discodermolide intermediates from engineered polyketides by Burlingame, Mark A., Mendoza, Esteban, Ashley, Gary W., Myles, David C.

“…Key intermediates used in Smith’s total synthesis of discodermolide were synthesized from an engineered polyketide made via precusor feeding to genetically…”
Get full text

N-Acyl-2-benzoxazolinones in titanium-mediated aldol reactions by Burlingame, Mark A., Mendoza, Esteban, Ashley, Gary W.

“…Graphic N-Acyl-2-benzoxazolinones readily form trichlorotitanium enolates that react rapidly with aldehydes to provide crystalline syn-aldol adducts in high…”
Get full text