Search Results - "Burks, Scott R"

Disrupting the blood–brain barrier by focused ultrasound induces sterile inflammation by Kovacs, Zsofia I., Kim, Saejeong, Jikaria, Neekita, Qureshi, Farhan, Milo, Blerta, Lewis, Bobbi K., Bresler, Michele, Burks, Scott R., Frank, Joseph A.

“…MRI-guided pulsed focused ultrasound (pFUS) combined with systemic infusion of ultrasound contrast agent microbubbles (MB) causes localized blood–brain barrier…”
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Temporally distinct myeloid cell responses mediate damage and repair after cerebrovascular injury by Mastorakos, Panagiotis, Mihelson, Nicole, Luby, Marie, Burks, Scott R., Johnson, Kory, Hsia, Amie W., Witko, Jaclyn, Frank, Joseph A., Latour, Lawrence, McGavern, Dorian B.

“…Cerebrovascular injuries can cause severe edema and inflammation that adversely affect human health. Here, we observed that recanalization after successful…”
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Chlorotoxin-A Multimodal Imaging Platform for Targeting Glioma Tumors by Cohen, Gadi, Burks, Scott R, Frank, Joseph A

“…Chlorotoxin (CTX) is a 36-amino-acid disulfide-containing peptide derived from the venom of the scorpion . CTX alters physiology in numerous ways. It interacts…”
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REPLY TO SILBURT ET AL: Concerning sterile inflammation following focused ultrasound and microbubbles in the brain by Kovacs, Zsofia I., Burks, Scott R., Frank, Joseph A.

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Cytosolic Ca2+ transients during pulsed focused ultrasound generate reactive oxygen species and cause DNA damage in tumor cells by Rosenblatt, Robert B, Frank, Joseph A, Burks, Scott R

“…Mechanical forces from non-ablative pulsed focused ultrasound (pFUS) generate pro-inflammatory tumor microenvironments (TME), marked by increased cytokines,…”
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Microbubbles bound to drug-eluting beads enable ultrasound imaging and enhanced delivery of therapeutics by Owen, Joshua, Negussie, Ayele H., Burks, Scott R., Delgado, Jose, Mikhail, Andrew S., Rivera, Jocelyne, Pritchard, William F., Karanian, John W., Stride, Eleanor, Frank, Joseph A., Wood, Bradford J.

“…Transarterial chemoembolization (TACE) is an image-guided minimally invasive treatment for liver cancer which involves delivery of chemotherapy and embolic…”
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MRI and histological evaluation of pulsed focused ultrasound and microbubbles treatment effects in the brain by Kovacs, Zsofia I, Tu, Tsang-Wei, Sundby, Maggie, Qureshi, Farhan, Lewis, Bobbi K, Jikaria, Neekita, Burks, Scott R, Frank, Joseph A

“…Magnetic resonance imaging (MRI)-guided pulsed focused ultrasound (pFUS) combined with microbubbles (MB) contrast agent infusion has been shown to transiently…”
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Investigation of cellular and molecular responses to pulsed focused ultrasound in a mouse model by Burks, Scott R, Ziadloo, Ali, Hancock, Hilary A, Chaudhry, Aneeka, Dean, Dana D, Lewis, Bobbi K, Frenkel, Victor, Frank, Joseph A

“…Continuous focused ultrasound (cFUS) has been widely used for thermal ablation of tissues, relying on continuous exposures to generate temperatures necessary…”
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Molecular and histological effects of MR-guided pulsed focused ultrasound to the rat heart by Jang, Kee W, Tu, Tsang-Wei, Nagle, Matthew E, Lewis, Bobbi K, Burks, Scott R, Frank, Joseph A

“…Image-guided high intensity focused ultrasound has been used as an extracorporeal cardiac pacing tool and to enhance homing of stem cells to targeted tissues…”
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The Impact of Focused Ultrasound in Two Tumor Models: Temporal Alterations in the Natural History on Tumor Microenvironment and Immune Cell Response by Cohen, Gadi, Chandran, Parwathy, Lorsung, Rebecca M, Tomlinson, Lauren E, Sundby, Maggie, Burks, Scott R, Frank, Joseph A

“…Image-guided focused ultrasound (FUS) has been successfully employed as an ablative treatment for solid malignancies by exposing immune cells to tumor…”
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Anti-inflammatory drugs suppress ultrasound-mediated mesenchymal stromal cell tropism to kidneys by Burks, Scott R., Nguyen, Ben A., Bresler, Michele N., Nagle, Matthew E., Kim, Saejeong J., Frank, Joseph A.

“…Mesenchymal stromal cells (MSC) are potential renal therapeutics. Clinically, results are mixed partly because MSC tropism to kidneys is minimal following…”
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In vivo EPR oximetry using an isotopically-substituted nitroxide: Potential for quantitative measurement of tissue oxygen by Weaver, John, Burks, Scott R., Liu, Ke Jian, Kao, Joseph P.Y., Rosen, Gerald M.

“…[Display omitted] •Anionic nature of carboxy-nitroxides aids their trapping and buildup in the brain.•15N-perdeuterionitroxide is ∼2-fold more sensitive as an…”
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Identification of prostaglandin E2 receptors mediating perinatal masculinization of adult sex behavior and neuroanatomical correlates by Wright, Christopher L., Burks, Scott R., McCarthy, Margaret M.

“…Prostaglandin E2 (PGE2) mediates the organization of male rat sexual behavior and medial preoptic area (MPOA) neuroanatomy during a sensitive perinatal window…”
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Acoustic Radiation or Cavitation Forces From Therapeutic Ultrasound Generate Prostaglandins and Increase Mesenchymal Stromal Cell Homing to Murine Muscle by Lorsung, Rebecca M., Rosenblatt, Robert B., Cohen, Gadi, Frank, Joseph A., Burks, Scott R.

“…Non-ablative ultrasound (US)-based techniques to improve targeted tropism of systemically infused cell therapies, particularly mesenchymal stromal cell (MSC),…”
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Co-encapsulating the fusogenic peptide INF7 and molecular imaging probes in liposomes increases intracellular signal and probe retention by Burks, Scott R, Legenzov, Eric A, Martin, Erik W, Li, Changqing, Lu, Wuyuan, Kao, Joseph P Y

“…Liposomes are promising vehicles to deliver diagnostic and therapeutic agents to cells in vivo. After uptake into cells by endocytosis, liposomes are degraded…”
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Neuroinflammation associated with ultrasound-mediated permeabilization of the blood–brain barrier by Jung, Olive, Thomas, Alec, Burks, Scott R., Dustin, Michael L., Frank, Joseph A., Ferrer, Marc, Stride, Eleanor

“…The blood–brain barrier (BBB) continues to represent one of the most significant challenges for successful drug-based treatments of neurological disease…”
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The Effect of Structure on Nitroxide EPR Spectral Linewidth by Burks, Scott R, Makowsky, Mallory A, Yaffe, Zachary A, Hoggle, Chad, Tsai, Pei, Muralidharan, Sukumaran, Bowman, Michael K, Kao, Joseph P.Y, Rosen, Gerald M

“…Nitroxides with narrow linewidths are essential for low-frequency EPR spectroscopy and in vivo EPR imaging. In developing a framework for designing narrow-line…”
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Focused ultrasound with microbubbles induces sterile inflammatory response proportional to the blood brain barrier opening: Attention to experimental conditions by Kovacs, Zsofia I, Burks, Scott R, Frank, Joseph A

“…This editorial highlights the findings of McMahon [1] and demonstrates the need for careful attention to experimental conditions that influence microbubble…”
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Blood–brain barrier opening by intracarotid artery hyperosmolar mannitol induces sterile inflammatory and innate immune responses by Burks, Scott R., Kersch, Cymon N., Witko, Jaclyn A., Pagel, Michael A., Sundby, Maggie, Muldoon, Leslie L., Neuwelt, Edward A., Frank, Joseph A.

“…Intracarotid arterial hyperosmolar mannitol (ICAHM) blood–brain barrier disruption (BBBD) is effective and safe for delivery of therapeutics for central…”
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The Proteomic Effects of Pulsed Focused Ultrasound on Tumor Microenvironments of Murine Melanoma and Breast Cancer Models by Aydin, Omer, Chandran, Parwathy, Lorsung, Rebecca R, Cohen, Gadi, Burks, Scott R, Frank, Joseph A

“…AbstractNon-ablative pulsed focused ultrasound (pFUS) targets non-thermal forces that activate local molecular and cellular immune responses. Optimal…”
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