Search Results - "Burkholder, J K"

In vivo Cytokine Gene Transfer by Gene Gun Reduces Tumor Growth in Mice by Sun, Wenn H., Burkholder, Joseph K., Sun, Jian, Culp, Jerilyn, Turner, Joel, Lu, Xing G., Pugh, Thomas D., Ershler, William B., Yang, Ning-Sun

“…Implantation of tumor cells modified by in vitro cytokine gene transfer has been shown by many investigators to result in potent in vivo antitumor activities…”
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Establishment of an Adherent Cell Feeder Layer from Human Umbilical Cord Blood for Support of Long-Term Hematopoietic Progenitor Cell Growth by Z.-Q. Ye, Burkholder, J. K., Qiu, P., Schultz, J. C., Shahidi, N. T., Yang, N. S.

“…Previous attempts to establish a stromal cell feeder layer from human umbilical cord blood (HUCB) have met with very limited success. It has been suggested…”
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Development of human granulocyte-macrophage colony-stimulating factor-transfected tumor cell vaccines for the treatment of spontaneous canine cancer by Hogge, G S, Burkholder, J K, Culp, J, Albertini, M R, Dubielzig, R R, Keller, E T, Yang, N S, MacEwen, E G

“…Cytokine gene-engineered tumor vaccines are currently an area of intense investigation in both basic research and clinical medicine. Our efforts to utilize…”
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Preclinical development of human granulocyte-macrophage colony-stimulating factor-transfected melanoma cell vaccine using established canine cell lines and normal dogs by Hogge, G S, Burkholder, J K, Culp, J, Albertini, M R, Dubielzig, R R, Yang, N S, MacEwen, E G

“…Tumor vaccines and gene therapy have received significant attention as means of increasing cellular and humoral immune responses to cancer. We conducted a…”
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Induction of antigen-specific CD8+ T cells, T helper cells, and protective levels of antibody in humans by particle-mediated administration of a hepatitis B virus DNA vaccine by Roy, Michael J, Wu, Mary S, Barr, Lori James, Fuller, James T, Tussey, Lynda G, Speller, Sue, Culp, Jerilyn, Burkholder, Joseph K, Swain, William F, Dixon, Russell M, Widera, Georg, Vessey, Rupert, King, Abbi, Ogg, Graham, Gallimore, Awen, Haynes, Joel R, Heydenburg Fuller, Deborah

“…A DNA vaccine against the hepatitis B virus (HBV) was evaluated for safety and induction of immune responses in 12 healthy, hepatitis-naı̈ve human volunteers…”
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Granulocyte-macrophage colony-stimulating factor mRNA stabilization enhances transgenic expression in normal cells and tissues by RAJAGOPALAN, L. E, BURKHOLDER, J. K, TURNER, J, CULP, J, NING-SUN YANG, MALTER, J. S

“…To increase transgenic production of granulocyte-macrophage colony-stimulating factor (GM-CSF), we mutated the mRNA's 3'-untranslated region, AUUUA instability…”
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Transient Promoter Activity in Primary Rat Mammary Epithelial Cells Evaluated Using Particle Bombardment Gene Transfer by T. Anthony Thompson, Gould, Michael N., Burkholder, Joseph K., Yang, Ning-Sun

“…The relative strengths of several commonly used viral promoters in primary cultures of rat mammary epithelial cells were studied using a particle bombardment…”
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Expression of a tumor-reactive antibody-interleukin 2 fusion protein after in vivo particle-mediated gene delivery by Nicolet, C M, Burkholder, J K, Gan, J, Culp, J, Kashmiri, S V, Schlom, J, Yang, N S, Sondel, P M

“…We have used a particle-mediated gene transfer method to analyze the posttransfection expression pattern of an antibody-cytokine fusion protein (FP) in vivo…”
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Transcriptional regulatory and response mapping of the rat Ha-ras upstream sequence using primary mammary epithelial cells by Ariazi, E A, Thompson, T A, Burkholder, J K, Yang, N S, Gould, M N

“…The rat Ha-ras upstream sequence (-2876 to +986 bp relative to the most 5' transcriptional start site) was transcriptionally mapped at a gross level. Ha-ras…”
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Particle-mediated gene transfer of granulocyte-macrophage colony-stimulating factor cDNA to tumor cells: implications for a clinically relevant tumor vaccine by Mahvi, D M, Burkholder, J K, Turner, J, Culp, J, Malter, J S, Sondel, P M, Yang, N S

“…The necessity for prolonged tissue culture manipulations limits the clinical application of many form of gene therapy in patients with malignancies. We…”
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Broadened clinical utility of gene gun-mediated, granulocyte-macrophage colony-stimulating factor cDNA-based tumor cell vaccines as demonstrated with a mouse myeloma model by Turner, J G, Tan, J, Crucian, B E, Sullivan, D M, Ballester, O F, Dalton, W S, Yang, N S, Burkholder, J K, Yu, H

“…Effective immunization against the murine B16 melanoma by a nonviral approach in which a gene gun is used to transfer GM-CSF cDNA into tumor cells has been…”
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Rapid transgene expression in lymphocyte and macrophage primary cultures after particle bombardment-mediated gene transfer by Burkholder, J K, Decker, J, Yang, N S

“…A particle bombardment technique was used for gene transfer to human peripheral blood mononuclear cells, and murine splenocytes, thymocytes and peritoneal…”
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Cytokine transgene expression and promoter usage in primary CD34+ cells using particle-mediated gene delivery by Ye, Z Q, Qiu, P, Burkholder, J K, Turner, J, Culp, J, Roberts, T, Shahidi, N T, Yang, N S

“…Induction or short-term transgenic expression of specific cytokines, growth factors, or other candidate therapeutic genes in hematopoietic progenitor or stem…”
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In vivo particle-mediated cytokine gene transfer into canine oral mucosa and epidermis by Keller, E T, Burkholder, J K, Shi, F, Pugh, T D, McCabe, D, Malter, J S, MacEwen, E G, Yang, N S, Ershler, W B

“…Cytokines can stimulate immune effector cells present within the oral mucosa and epidermis to respond to vaccination or to combat cancer. However, intravenous…”
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Granulocyte-macrophage colony-stimulating factor mRNA stabilization enhances transgenic expression in normal cells and tissues by Rajagopalan, LE, Burkholder, JK, Turner, J, Culp, J, Yang, NS, Malter, JS

“…To increase transgenic production of granulocyte-macrophage colony-stimulating factor (GM-CSF), we mutated the mRNA's 32-untranslated region, AUUUA instability…”
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