Search Results - "Burkey, Thomas H"

Isolation and culture of sensory neurons from the dorsal-root ganglia of embryonic or adult rats by Burkey, Thomas H, Hingtgen, Cynthia M, Vasko, Michael R

“…There is increasing use of isolated sensory neuronal preparations to examine the cellular mechanisms involved in pain signaling. Indeed, these in viro…”
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Tumor necrosis factor α and interleukin-1β stimulate the expression of cyclooxygenase II but do not alter prostaglandin E2 receptor mRNA levels in cultured dorsal root ganglia cells by FEHRENBACHER, Jill C, BURKEY, Thomas H, NICOL, Grant D, VASKO, Michael R

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Relative efficacies of cannabinoid CB1 receptor agonists in the mouse brain by BURKEY, T. H, QUOCK, R. M, CONSROE, P, EHLERT, F. J, HOSOHATA, Y, ROESKE, W. R, YAMAMURA, H. I

“…We measured (-)-5-(1,1-dimethylheptyl)-2-[5-hydroxy-2-(3-hydroxypropyl)cyclohe xyl]-phenol (CP 55,940)-, (-)11-OH-delta8-tetrahydrocannabinol-dimethylheptyl…”
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6-isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809), a human EP2 receptor antagonist by WOODWARD, D. F, PEPPERL, D. J, BURKEY, T. H, REGAN, J. W

“…On studying the interaction of various ligands with the pharmacologically defined, recombinant human EP2 receptor (Regan et al., Mol Pharmacol 46: 213-220,…”
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δ-Opioid receptor agonists produce antinociception and [ 35S]GTPγS binding in μ receptor knockout mice by Hosohata, Yoshiaki, Vanderah, Todd W, Burkey, Thomas H, Ossipov, Michael H, Kovelowski, Carl J, Sora, Ichiro, Uhl, George R, Zhang, Xiaoyan, Rice, Kenner C, Roeske, William R, Hruby, Victor J, Yamamura, Henry I, Lai, Josephine, Porreca, Frank

“…We examined the effects of [ d-Pen 2, d-Pen 5]enkephalin (DPDPE), [ d-Ala 2,Glu 4]deltorphin (DELT), and (+)-4-[(α R)-α((2 S,5…”
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Endomorphin-1 and endomorphin-2 are partial agonists at the human μ-opioid receptor by Hosohata, Keiko, Burkey, Thomas H, Alfaro-Lopez, Josue, Varga, Eva, Hruby, Victor J, Roeske, William R, Yamamura, Henry I

“…Recently two tetrapeptide ligands that bind preferentially to the μ-opioid receptor were identified and named endomorphin-1 and endomorphin-2. We examined the…”
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The role of the G protein γ2 subunit in opioid antinociception in mice by HOSOHATA, K, LOGAN, J. K, VARGA, E, BURKEY, T. H, VANDERAH, T. W, PORRECA, F, HRUBY, V. J, ROESKE, W. R, YAMAMURA, H. I

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(2 S,3 R)TMT- l-Tic-OH is a potent inverse agonist at the human δ-opioid receptor by Hosohata, Keiko, Burkey, Thomas H, Alfaro-Lopez, Josua, Hruby, Victor J, Roeske, William R, I. Yamamura, Henry

“…We examined the pharmacologic effect of β-methyl-2′,6′-dimethyltyrosine- l-tetrahydroisoquinoline-3-carboxylic acid ((2 S,3 R)TMT- l-Tic-OH) on G protein…”
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Adenosine inhibits fMLP-stimulated adherence and superoxide anion generation by human neutrophils at an early step in signal transduction by Burkey, T H, Webster, R O

“…The ability of physiological concentrations of adenosine to inhibit formylmethionylleucylphenylalanine (fMLP)-stimulated superoxide anion (O2-) generation,…”
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Tumor necrosis factor α and interleukin-1β stimulate the expression of cyclooxygenase II but do not alter prostaglandin E 2 receptor mRNA levels in cultured dorsal root ganglia cells by Fehrenbacher, Jill C., Burkey, Thomas H., Nicol, Grant D., Vasko, Michael R.

“…Tumor necrosis factor α (TNFα) and interleukin 1β (IL-1β) are pro-inflammatory cytokines capable of altering the sensitivity of sensory neurons. Because…”
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SR141716A is an inverse agonist at the human cannabinoid CB1 receptor by Landsman, R S, Burkey, T H, Consroe, P, Roeske, W R, Yamamura, H I

“…The effects of R(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4- benzoxazin-yl]-(1-napthalenyl)methanone mesylate (WIN 55,212-2) and…”
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The delta-opioid receptor: molecular pharmacology, signal transduction, and the determination of drug efficacy by Quock, R M, Burkey, T H, Varga, E, Hosohata, Y, Hosohata, K, Cowell, S M, Slate, C A, Ehlert, F J, Roeske, W R, Yamamura, H I

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SR141716A is an inverse agonist at the human cannabinoid CB1 receptor by LANDSMAN, R. S, BURKEY, T. H, CONSROE, P, ROESKE, W. R, YAMAMURA, H. I

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Tumor necrosis factor alpha and interleukin-1beta stimulate the expression of cyclooxygenase II but do not alter prostaglandin E2 receptor mRNA levels in cultured dorsal root ganglia cells by Fehrenbacher, Jill C, Burkey, Thomas H, Nicol, Grant D, Vasko, Michael R

“…Tumor necrosis factor alpha (TNFalpha) and interleukin 1beta (IL-1beta) are pro-inflammatory cytokines capable of altering the sensitivity of sensory neurons…”
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AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain by Hosohata, Keiko, Quock, Raymond M., Hosohata, Yoshiaki, Burkey, Thomas H., Makriyannis, Alexandros, Consroe, Paul, Roeske, William R., Yamamura, Henry I.

“…AM 630 has been demonstrated to be a cannabinoid receptor antagonist in the mouse brain and vas deferens. Conversely, it was recently reported that AM630 acts…”
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Activation of Mitogen-Activated Protein Kinase by the Human Prostaglandin EP3A Receptor by Burkey, T.H., Regan, J.W.

“…Mitogen-activated protein (MAP) kinases are involved with cellular proliferation, and while the traditional activators of these kinases have been the growth…”
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Differential down-regulation of the human δ-opioid receptor by SNC80 and [ d-Pen 2, d-Pen 5]enkephalin by Okura, Takashi, Cowell, Scott M, Varga, Eva, Burkey, Thomas H, Roeske, William R, Hruby, Victor J, Yamamura, Henry I

“…We examined the contribution of the human δ-opioid receptor carboxyl terminal tail to (+)-4-[(α R)-α-((2 S,5…”
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The role of the G protein γ 2 subunit in opioid antinociception in mice by Hosohata, Keiko, Logan, Jennifer K, Varga, Eva, Burkey, Thomas H, Vanderah, Todd W, Porreca, Frank, Hruby, Victor J, Roeske, William R, Yamamura, Henry I

“…We examined the role of the γ 2 subunit of G proteins (Gγ 2) in the antinociception produced by c[D-Pen 2,D-Pen 5]enkephalin (DPDPE) in mice. DPDPE produced…”
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SR141716A is an inverse agonist at the human cannabinoid CB 1 receptor by Landsman, Robert S, Burkey, Thomas H, Consroe, Paul, Roeske, William R, Yamamura, Henry I

“…The effects of R(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3- de]-1,4-benzoxazin-yl]-(1-napthalenyl)methanone mesylate (WIN 55,212-2) and…”
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Relative efficacies of δ-opioid receptor agonists at the cloned human δ-opioid receptor by Quock, Raymond M, Hosohata, Yoshiaki, Knapp, Richard J, Burkey, Thomas H, Hosohata, Keiko, Zhang, Xiaoyan, Rice, Kenner C, Nagase, Hiroshi, Hruby, Victor J, Porreca, Frank, Roeske, William R, Yamamura, Henry I

“…The present study was conducted to determine the relative efficacies of the selective δ-opioid receptor agonists SNC80 ((+)-4-[(α R)-α-((2 S,5…”
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