Search Results - "Burke, Zoé D"

Liver Zonation Occurs Through a β-Catenin–Dependent, c-Myc–Independent Mechanism by Burke, Zoé D, Reed, Karen R, Phesse, Toby J, Sansom, Owen J, Clarke, Alan R, Tosh, David

“…Background and Aims The Wnt pathway has previously been shown to play a role in hepatic zonation. Herein, we have explored the role of 3 key components (Apc,…”
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B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver by Reed, Karen R, Athineos, Dimitris, Meniel, Valerie S, Wilkins, Julie A, Ridgway, Rachel A, Burke, Zoé D, Muncan, Vanesa, Clarke, Alan R, Sansom, Owen J

“…Dysregulated Wnt signaling is seen in approximately 30% of hepatocellular carcinomas; thus, finding pathways downstream of the activation of Wnt signaling is…”
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Human Breast Cancer Cells Demonstrate Electrical Excitability by Ribeiro, Mafalda, Elghajiji, Aya, Fraser, Scott P, Burke, Zoë D, Tosh, David, Djamgoz, Mustafa B A, Rocha, Paulo R F

“…Breast cancer is one of the most prevalent types of cancers worldwide and yet, its pathophysiology is poorly understood. Single-cell electrophysiological…”
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The Canonical Wnt Pathway as a Key Regulator in Liver Development, Differentiation and Homeostatic Renewal by Wild, Sebastian L., Elghajiji, Aya, Grimaldos Rodriguez, Carmen, Weston, Stephen D., Burke, Zoë D., Tosh, David

“…The canonical Wnt (Wnt/β-catenin) signalling pathway is highly conserved and plays a critical role in regulating cellular processes both during development and…”
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Barrett's metaplasia as a paradigm for understanding the development of cancer by Burke, Zoë D, Tosh, David

“…The conversion of one cell type to another is defined as metaplasia (or sometimes it is referred to as transdifferentiation or cellular reprogramming)…”
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Editorial: Cellular reprogramming in development, disease, and design of cell-replacement therapies by Burke, Zoë D., Lyon, Cressida, Perán, Macarena

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Spatiotemporal regulation of liver development by the Wnt/β-catenin pathway by Burke, Zoë D., Reed, Karen R., Yeh, Sheng-Wen, Meniel, Valerie, Sansom, Owen J., Clarke, Alan R., Tosh, David

“…While the Wnt/β-catenin pathway plays a critical role in the maintenance of the zonation of ammonia metabolizing enzymes in the adult liver, the mechanisms…”
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MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity by Kia, Richard, Kelly, Lorna, Sison-Young, Rowena L C, Zhang, Fang, Pridgeon, Chris S, Heslop, James A, Metcalfe, Pete, Kitteringham, Neil R, Baxter, Melissa, Harrison, Sean, Hanley, Neil A, Burke, Zoë D, Storm, Mike P, Welham, Melanie J, Tosh, David, Küppers-Munther, Barbara, Edsbagge, Josefina, Starkey Lewis, Philip J, Bonner, Frank, Harpur, Ernie, Sidaway, James, Bowes, Joanne, Fenwick, Stephen W, Malik, Hassan, Goldring, Chris E P, Park, B Kevin

“…Emerging hepatic models for the study of drug-induced toxicity include pluripotent stem cell-derived hepatocyte-like cells (HLCs) and complex…”
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Correction: Dexamethasone Treatment Induces the Reprogramming of Pancreatic Acinar Cells to Hepatocytes and Ductal Cells by Al-Adsani, Amani, Burke, Zoë D, Eberhard, Daniel, Lawrence, Katherine L, Shen, Chia-Ning, Rustgi, Anil K, Sakaue, Hiroshi, Mark Farrant, J, Tosh, David

“…[This corrects the article DOI: 10.1371/journal.pone.0013650.]…”
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Hnf4α is a key gene that can generate columnar metaplasia in oesophageal epithelium by Colleypriest, Benjamin J., Burke, Zoë D., Griffiths, Leonard P., Chen, Yu, Yu, Wei-Yuan, Jover, Ramiro, Bock, Michael, Biddlestone, Leigh, Quinlan, Jonathan M., Ward, Stephen G., Mark Farrant, J., Slack, Jonathan M.W., Tosh, David

“…Barrett's metaplasia is the only known morphological precursor to oesophageal adenocarcinoma and is characterized by replacement of stratified squamous…”
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Stem cells in the adult pancreas and liver by Burke, Zoë D, Thowfeequ, Shifaan, Peran, Macarena, Tosh, David

“…Stem cells are undifferentiated cells that can self-renew and generate specialized (functional) cell types. The remarkable ability of stem cells to…”
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The Wnt/β-catenin pathway: master regulator of liver zonation? by Burke, Zoë D., Tosh, David

“…The liver contains two systems for the removal of ammonia—the urea cycle and the enzyme glutamine synthetase. These systems are expressed in a complementary…”
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Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo by Buchert, Michael, Athineos, Dimitris, Abud, Helen E, Burke, Zoe D, Faux, Maree C, Samuel, Michael S, Jarnicki, Andrew G, Winbanks, Catherine E, Newton, Ian P, Meniel, Valerie S, Suzuki, Hiromu, Stacker, Steven A, Näthke, Inke S, Tosh, David, Huelsken, Joerg, Clarke, Alan R, Heath, Joan K, Sansom, Owen J, Ernst, Matthias

“…Contributions of null and hypomorphic alleles of Apc in mice produce both developmental and pathophysiological phenotypes. To ascribe the resulting…”
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Dexamethasone treatment induces the reprogramming of pancreatic acinar cells to hepatocytes and ductal cells by Al-Adsani, Amani, Burke, Zoë D, Eberhard, Daniel, Lawrence, Katherine L, Shen, Chia-Ning, Rustgi, Anil K, Sakaue, Hiroshi, Farrant, J Mark, Tosh, David

“…The pancreatic exocrine cell line AR42J-B13 can be reprogrammed to hepatocytes following treatment with dexamethasone. The question arises whether…”
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Molecular aspects of esophageal development by Rishniw, Mark, Rodriguez, Pavel, Que, Jianwen, Burke, Zoe D., Tosh, David, Chen, Hao, Chen, Xiaoxin

“…The following on molecular aspects of esophageal development contains commentaries on esophageal striated myogenesis and transdifferentiation; conversion from…”
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Ontogenesis of Hepatic and Pancreatic Stem Cells by Burke, Zoë D., Tosh, David

“…In the embryo, the liver and pancreas exhibit a close developmental relationship. Both tissues arise from neighbouring regions of the developing endoderm. As…”
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Therapeutic potential of transdifferentiated cells by Burke, Zoë D, Tosh, David

“…Cell therapy means treating diseases with the body's own cells. The ability to produce differentiated cell types at will offers a compelling new approach to…”
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Liver Specification: A New Role for Wnts in Liver Development by Burke, Zoë D., Thowfeequ, Shifaan, Tosh, David

“…Secreted Wnt proteins control a diverse array of developmental decisions. A recent analysis of the zebrafish mutant prometheus points to a previously unknown…”
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Isolation and culture of embryonic pancreas and liver by Burke, Zoë D, Li, Wan-Chun, Slack, Jonathan M W, Tosh, David

“…Culturing embryonic tissue in an in vitro setting offers the unique ability to manipulate the external medium and therefore to investigate the pathways…”
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Transdifferentiation, Metaplasia and Tissue Regeneration by SHEN, CHIA-NING, Burke, Zoë D, Tosh, David

“…Transdifferentiation is defined as the conversion of one cell type to another. It belongs to a wider class of cell type transformations called metaplasias…”
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