Search Results - "Burke, Terrence R."

Refine Results
  1. 1

    Chemically Programmable and Switchable CAR‐T Therapy by Qi, Junpeng, Tsuji, Kohei, Hymel, David, Burke, Terrence R., Hudecek, Michael, Rader, Christoph, Peng, Haiyong

    Published in Angewandte Chemie International Edition (13-07-2020)
    “…Although macromolecules on cell surfaces are predominantly targeted and drugged with antibodies, they harbor pockets that are only accessible to small…”
    Get full text
    Journal Article
  2. 2

    Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets by Lu, Xiuxiu, Nowicka, Urszula, Sridharan, Vinidhra, Liu, Fen, Randles, Leah, Hymel, David, Dyba, Marzena, Tarasov, Sergey G., Tarasova, Nadya I., Zhao, Xue Zhi, Hamazaki, Jun, Murata, Shigeo, Burke, Jr, Terrence R., Walters, Kylie J.

    Published in Nature communications (09-06-2017)
    “…Proteasome–ubiquitin receptor hRpn13/Adrm1 binds and activates deubiquitinating enzyme Uch37/UCHL5 and is targeted by bis-benzylidine piperidone RA190, which…”
    Get full text
    Journal Article
  3. 3

    Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates by Nanna, Alex R., Li, Xiuling, Walseng, Even, Pedzisa, Lee, Goydel, Rebecca S., Hymel, David, Burke Jr, Terrence R., Roush, William R., Rader, Christoph

    Published in Nature communications (24-10-2017)
    “…Current strategies to produce homogeneous antibody-drug conjugates (ADCs) rely on mutations or inefficient conjugation chemistries. Here we present a strategy…”
    Get full text
    Journal Article
  4. 4

    Application of a Fluorescence Recovery-Based Polo-Like Kinase 1 Binding Assay to Polo-Like Kinase 2 and Polo-Like Kinase 3 by Tsuji, Kohei, Tamamura, Hirokazu, Burke, Terrence R., Jr

    Published in Biological & pharmaceutical bulletin (11-07-2024)
    “…Assay systems for evaluating compound protein-binding affinities are essential for developing agonists and/or antagonists. Targeting individual members of a…”
    Get full text
    Journal Article
  5. 5

    Efficacies of Cabotegravir and Bictegravir against drug-resistant HIV-1 integrase mutants by Smith, Steven J, Zhao, Xue Zhi, Burke, Jr, Terrence R, Hughes, Stephen H

    Published in Retrovirology (16-05-2018)
    “…Integrase strand transfer inhibitors (INSTIs) are the class of antiretroviral (ARV) drugs most recently approved by the FDA for the treatment of HIV-1…”
    Get full text
    Journal Article
  6. 6

    Synthetic Approaches to a Key Pyridone-carboxylic Acid Precursor Common to the HIV‑1 Integrase Strand Transfer Inhibitors Dolutegravir, Bictegravir, and Cabotegravir by Mahajan, Pankaj S., Burke, Terrence R.

    Published in Organic process research & development (19-05-2023)
    “…Dolutegravir (DTG), Bictegravir (BIC), and Cabotegravir (CAB) are the second-generation integrase strand transfer inhibitors (INSTIs) that have been…”
    Get full text
    Journal Article
  7. 7

    Recent Advances and New Strategies in Targeting Plk1 for Anticancer Therapy by Lee, Kyung S, Burke, Terrence R, Park, Jung-Eun, Bang, Jeong K, Lee, Eunhye

    “…Polo-like kinase 1 (Plk1) plays key roles in regulating mitotic processes that are crucial for cellular proliferation. Overexpression of Plk1 is tightly…”
    Get full text
    Journal Article
  8. 8

    Site-Specific Lysine Arylation as an Alternative Bioconjugation Strategy for Chemically Programmed Antibodies and Antibody–Drug Conjugates by Hwang, Dobeen, Tsuji, Kohei, Park, HaJeung, Burke, Terrence R, Rader, Christoph

    Published in Bioconjugate chemistry (20-11-2019)
    “…By exploiting a uniquely reactive lysine residue (Lys99) for site-specific attachment of small molecules, the humanized catalytic antibody h38C2 has been used…”
    Get full text
    Journal Article
  9. 9

    Integrase Strand Transfer Inhibitors Are Effective Anti-HIV Drugs by Smith, Steven J, Zhao, Xue Zhi, Passos, Dario Oliveira, Lyumkis, Dmitry, Burke, Jr, Terrence R, Hughes, Stephen H

    Published in Viruses (29-01-2021)
    “…Integrase strand transfer inhibitors (INSTIs) are currently recommended for the first line treatment of human immunodeficiency virus type one (HIV-1)…”
    Get full text
    Journal Article
  10. 10

    Developing and Evaluating Inhibitors against the RNase H Active Site of HIV-1 Reverse Transcriptase by Boyer, Paul L, Smith, Steven J, Zhao, Xue Zhi, Das, Kalyan, Gruber, Kevin, Arnold, Eddy, Burke, Jr, Terrence R, Hughes, Stephen H

    Published in Journal of virology (01-07-2018)
    “…We tested three compounds for their ability to inhibit the RNase H (RH) and polymerase activities of HIV-1 reverse transcriptase (RT). A high-resolution…”
    Get full text
    Journal Article
  11. 11
  12. 12

    Retroviral DNA integration: reaction pathway and critical intermediates by Li, Min, Mizuuchi, Michiyo, Burke Jr, Terrence R, Craigie, Robert

    Published in The EMBO journal (22-03-2006)
    “…The key DNA cutting and joining steps of retroviral DNA integration are carried out by the viral integrase protein. Structures of the individual domains of…”
    Get full text
    Journal Article
  13. 13

    Uncoupling the Folding-Function Paradigm of Lytic Peptides to Deliver Impermeable Inhibitors of Intracellular Protein–Protein Interactions by Miller, Stephen E, Tsuji, Kohei, Abrams, Rachel P.M, Burke, Terrence R, Schneider, Joel P

    Published in Journal of the American Chemical Society (25-11-2020)
    “…Here, we describe the use of peptide backbone N-methylation as a new strategy to transform membrane-lytic peptides (MLPs) into cytocompatible intracellular…”
    Get full text
    Journal Article
  14. 14
  15. 15

    Examination of aminophenol-containing compounds designed as antiproliferative agents and potential atypical retinoids by Chingle, Ramesh M., Imai, Masahiko, Altman, Sarah, Saito, Daisuke, Takahashi, Noriko, Burke, Terrence R.

    Published in Bioorganic & medicinal chemistry (15-03-2023)
    “…[Display omitted] Retinoic acid (RA, 1), an oxidized form of vitamin A, binds to retinoic acid receptors (RAR) and retinoid X receptors (RXR) to regulate gene…”
    Get full text
    Journal Article
  16. 16

    A Practical Approach to Bicyclic Carbamoyl Pyridones with Application to the Synthesis of HIV-1 Integrase Strand Transfer Inhibitors by Mahajan, Pankaj S, Smith, Steven J, Hughes, Stephen H, Zhao, Xuezhi, Burke, Jr, Terrence R

    Published in Molecules (Basel, Switzerland) (01-02-2023)
    “…An efficient one-pot synthetic method has been developed for the preparation of bicyclic carbamoyl pyridones from the known common intermediate methyl…”
    Get full text
    Journal Article
  17. 17

    Affinity enhancement of polo-like kinase 1 polo box domain-binding ligands by a bivalent approach using a covalent kinase-binding component by Tsuji, Kohei, Tamamura, Hirokazu, Burke, Jr, Terrence R

    Published in RSC chemical biology (31-07-2024)
    “…The polo-like kinase 1 (Plk1) is an important cell cycle regulator that is recognized as a target molecule for development of anti-cancer agents. Plk1 consists…”
    Get full text
    Journal Article
  18. 18

    Histidine N(τ)-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inhibitors by Hymel, David, Grant, Robert A., Tsuji, Kohei, Yaffe, Michael B., Burke, Terrence R.

    Published in Bioorganic & medicinal chemistry letters (15-10-2018)
    “…[Display omitted] •Peptide macrocyclization is an important step in advancing peptides to peptidomimetics.•Size reduction of Plk1 PBD-binding peptides with…”
    Get full text
    Journal Article
  19. 19

    Application of Post Solid-Phase Oxime Ligation to Fine-Tune Peptide-Protein Interactions by Zhao, Xue Zhi, Liu, Fa, Burke, Jr, Terrence R

    Published in Molecules (Basel, Switzerland) (18-06-2020)
    “…Protein-protein interactions (PPIs) represent an extremely attractive class of potential new targets for therapeutic intervention; however, the shallow…”
    Get full text
    Journal Article
  20. 20