Search Results - "Burke, Sandra E."

Zotarolimus (ABT-578) eluting stents by Burke, Sandra E., Kuntz, Richard E., Schwartz, Lewis B.

“…Drug-eluting stents have revolutionized the field of interventional cardiology and have provided a significant innovation for preventing coronary artery…”
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Oral bimoclomol elevates heat shock protein 70 and reduces myocardial infarct size in rats by Lubbers, Nathan L, Polakowski, James S, Wegner, Craig D, Burke, Sandra E, Diaz, Gilbert J, Daniell, Katina M, Cox, Bryan F

“…Bimoclomol has been shown to increase an inducible member of the heat shock protein 70 family (HSP70) and cytoprotect in vitro. Here, we addressed whether oral…”
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Zotarolimus-eluting stents reduce experimental coronary artery neointimal hyperplasia after 4 weeks by Garcia-Touchard, Arturo, Burke, Sandra E., Toner, John L., Cromack, Keith, Schwartz, Robert S.

“…Aims The addition of drug elution to coronary stents plays an integral role in coronary restenosis prevention. The present study was undertaken to determine…”
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Zotarolimus, a Novel Sirolimus Analogue With Potent Anti-proliferative Activity on Coronary Smooth Muscle Cells and Reduced Potential for Systemic Immunosuppression by Chen, Yung-Wu, Smith, Morey L, Sheets, Michael, Ballaron, Steve, Trevillyan, James M, Burke, Sandra E, Rosenberg, Teresa, Henry, Cindy, Wagner, Rolf, Bauch, Joy, Marsh, Kennan, Fey, Thomas A, Hsieh, Gin, Gauvin, Donna, Mollison, Karl W, Carter, George W, Djuric, Stevan W

“…Sirolimus (rapamycin) is an immunosuppressant used in preventing allograft rejection and in drug-eluting stents to prevent restenosis after angioplasty…”
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Selective Antagonism of the ETA Receptor Reduces Neointimal Hyperplasia After Balloon-Induced Vascular Injury in Pigs by Burke, Sandra E, Lubbers, Nathan L, Gagne, Gerard D, Wessale, Jerry L, Dayton, Brian D, Wegner, Craig D, Opgenorth, Terry J

“…Balloon angioplasty has become an important intervention in clinical cardiology; however, the technique is associated with a high incidence of restenosis,…”
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Neointimal Formation After Balloon-Induced Vascular Injury in Yucatan Minipigs is Reduced by Oral Rapamycin by Burke, Sandra E, Lubbers, Nathan L, Chen, Yung-Wu, Hsieh, Gin C, Mollison, Karl W, Luly, Jay R, Wegner, Craig D

“…Rapamycin, a macrolide antibiotic known to prevent allograft rejection, is a potent inhibitor of cell proliferation. Therefore we studied the effects of orally…”
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Evaluation of tissue perfusion in a rat model of hind-limb muscle ischemia using dynamic contrast-enhanced magnetic resonance imaging by Luo, Yanping, Mohning, Kurt M., Hradil, Vincent P., Wessale, Jerry L., Segreti, Jason A., Nuss, Merrill E., Wegner, Craig D., Burke, Sandra E., Cox, Bryan F.

“…Purpose To evaluate the feasibility of using dynamic contrast‐enhanced magnetic resonance imaging (MRI) for assessment of muscle perfusion in a rat model of…”
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Protection of ischemic cat myocardium by CGS-13080, a selective potent thromboxane A2 synthesis inhibitor by Burke, S E, DiCola, G, Lefer, A M

“…A specific inhibitor of thromboxane A2 (TxA2) synthesis, CGS-13080, was studied during acute myocardial ischemia (MI) in cats. To define more clearly the…”
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Cardiotonic agents. 6. Synthesis and inotropic activity of 2,4-dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-3H-pyrazol-3-ones: ring-contracted analogs of imazodan (CI-914) by Sircar, Ila, Morrison, Glenn C, Burke, Sandra E, Skeean, Richard, Weishaar, Ronald E

“…A series of 2,4-dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-3H-pyrazol-3-ones was synthesized and evaluated for positive inotropic activity. Only compounds with two…”
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Evidence for Vasoconstriction Mediated by the Endothelin-B Receptor in Domestic Swine by Burke, Sandra E, Nelson, Richard A, Lubbers, Nathan L, Ford, TaLesha T, Fu, Kai I, Padley, Robert J, Wegner, Craig D, Cox, Bryan F

“…Endothelin-1 (ET-1), a potent vasoactive and mitogenic peptide, has been implicated in a number of cardiovascular diseases, including congestive heart failure,…”
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Endothelin-Receptor Antagonist FR 139317 Reduces Infarct Size in a Rabbit Model When Given Before, But Not After, Coronary Artery Occlusion by Burke, Sandra E, Nelson, Richard A

“…SUMMARYEndothelins are potent vasoactive peptides that exist as isoforms having different affinities for two main receptor subtypes, ETA and ETB. Based on…”
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Synthesis and biological activity of 4-(diphenylmethyl)-.alpha.-[(4-quinolinyloxy)methyl]-1-piperazineethanol and related compounds by Sircar, Ila, Haleen, Steve J, Burke, Sandra E, Barth, Hubert

“…A series of 4-(diphenylmethyl)-alpha-[(4-quinolinyloxy)methyl]-1-pipe razineethanol and closely related compounds was synthesized and evaluated for cardiac and…”
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Profile of recombinant pro-urokinase given by intraarterial versus intravenous routes of administration in a canine thrombosis model by Burke, S E, Lubbers, N L, Nelson, R A, Wegner, C D, Cox, B F

“…Catheter-directed thrombolysis has gained increasing acceptance for the treatment of patients who present with vascular occlusion; however, intravenous…”
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Fibrinolytic mechanism, biochemistry, and preclinical pharmacology of recombinant prourokinase by Credo, R B, Burke, S E

“…The purpose of this review is to provide a biochemical characterization of recombinant prourokinase (r-ProUK [ABT-187]), including a description of its…”
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Comparison of dose regimens for the administration of recombinant pro-urokinase in a canine thrombosis model by Burke, S E, Lubbers, N L, Nelson, R A, Henkin, J

“…Pro-urokinase represents an important addition to the array of thrombolytic drugs currently available for clinical use because of its high clot specificity but…”
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Cardiotonic agents. 4. Synthesis and biological evaluation of N-substituted 2,4,4a,5-tetrahydro-3H-indeno[1,2-c]pyridazin-3-ones: rigid structures derived from CI-930 and analogs by Sircar, Ila, Duell, Bradley L, Cain, Michael H, Burke, Sandra E, Bristol, James A

“…Several N-substituted 3H-indeno[1,2-c]pyridazinones (1-23) and a benzo[h]cinnolinone (24), which were designed as rigid structural modifications of…”
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Zotarolimus (ABT-578) eluting stents: Drug-eluting stents: an innovative multidisciplinary drug delivery platform by BURKE, Sandra E, KUNTZ, Richard E, SCHWARTZ, Lewis B

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Effects of Zotarolimus (ABT-578), Sirolimus, Paclitaxel and Dexamethasone on Cytokine Production by Human Monocytes In Vitro by Li, Lanlan, Burke, Sandra E., Mack, Matthew M.

“…Introduction: Percutaneous coronary intervention (PCI) and stenting are common therapies used to mitigate symptomatic coronary artery stenosis. These…”
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Reduction of canine myocardial infarct size by CI-959, an inhibitor of inflammatory cell activation by Burke, S E, Wright, C D, Potoczak, R E, Boucher, D M, Dodd, G D, Taylor, Jr, D G, Kaplan, H R

“…CI-959, a cell-activation inhibitor that prevents the formation of oxygen-derived free radicals by inflammatory cells, was studied to determine its effects on…”
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Role of thromboxanes and prostaglandin endoperoxides in the pathogenesis of eicosanoid induced sudden death by Lefer, A M, Burke, S E, Smith, J B

“…Arachidonic acid (1 mg/kg) or 9,11-azo PGH2 (35 micrograms/kg) injected intravenously into anesthetized rabbits results in sudden death characterized by a…”
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