Search Results - "Burke, Paul A."

Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies by Mitragotri, Samir, Burke, Paul A., Langer, Robert

“…Key Points Biopharmaceutical drugs such as antibodies, peptides and recombinant proteins have high specificity and potency compared to small molecules. These…”
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The Ups and Downs of Clinical Translation of New Technologies: Déjà Vu All Over Again by Burke, Paul A

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Predicting the efficiency of oxygen-evolving electrolysis on the Moon and Mars by Lomax, Bethany A., Just, Gunter H., McHugh, Patrick J., Broadley, Paul K., Hutchings, Gregory C., Burke, Paul A., Roy, Matthew J., Smith, Katharine L., Symes, Mark D.

“…Establishing a permanent human presence on the Moon or Mars requires a secure supply of oxygen for life support and refueling. The electrolysis of water has…”
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Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-treatment by Abrams, Marc T, Koser, Martin L, Seitzer, Jessica, Williams, Stephanie C, DiPietro, Martha A, Wang, Weimin, Shaw, Andrew W, Mao, Xianzhi, Jadhav, Vasant, Davide, Joseph P, Burke, Paul A, Sachs, Alan B, Stirdivant, Steven M, Sepp-Lorenzino, Laura

“…Despite recent progress, systemic delivery remains the major hurdle for development of safe and effective small inhibitory RNA (siRNA)–based therapeutics…”
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Mechanistically Probing Lipid-siRNA Nanoparticle-associated Toxicities Identifies Jak Inhibitors Effective in Mitigating Multifaceted Toxic Responses by Tao, Weikang, Mao, Xianzhi, Davide, Joseph P, Ng, Bruce, Cai, Mingmei, Burke, Paul A, Sachs, Alan B, Sepp-Lorenzino, Laura

“…A major hurdle for harnessing small interfering RNA (siRNA) for therapeutic application is an effective and safe delivery of siRNA to target tissues and cells…”
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Quantitative evaluation of siRNA delivery in vivo by Pei, Yi, Hancock, Paula J, Zhang, Hangchun, Bartz, René, Cherrin, Craig, Innocent, Nathalie, Pomerantz, Colin J, Seitzer, Jessica, Koser, Martin L, Abrams, Marc T, Xu, Yan, Kuklin, Nelly A, Burke, Paul A, Sachs, Alan B, Sepp-Lorenzino, Laura, Barnett, Stanley F

“…Effective small interfering RNA (siRNA)-mediated therapeutics require the siRNA to be delivered into the cellular RNA-induced silencing complex (RISC)…”
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Diffusivities of dichloromethane in poly(lactide-co-glycolide) by Foss, Willard R, Anderl, Jeffrey N, Clausi, Amber L, Burke, Paul A

“…Diffusion of dichloromethane in poly(lactide-co-glycolide) (PLGA), the rate-limiting step in the later stages of drying of microparticles formed in common…”
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Liver-targeted polymeric prodrugs of 8-aminoquinolines for malaria radical cure by Srinivasan, Selvi, Roy, Debashish, Chavas, Thomas E.J., Vlaskin, Vladimir, Ho, Duy-Khiet, Pottenger, Ayumi, LeGuyader, Clare L.M., Maktabi, Mahdi, Strauch, Pamela, Jackson, Conner, Flaherty, Siobhan M., Lin, Hsiuling, Zhang, Jing, Pybus, Brandon, Li, Qigui, Huber, Hans E., Burke, Paul A., Wesche, David, Rochford, Rosemary, Stayton, Patrick S.

“…Primaquine and tafenoquine are the two 8-aminoquinoline (8-AQ) antimalarial drugs approved for malarial radical cure - the elimination of liver stage…”
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Analysis of lipid nanoparticles by Cryo-EM for characterizing siRNA delivery vehicles by Crawford, Randy, Dogdas, Belma, Keough, Edward, Haas, R. Matthew, Wepukhulu, Wickliffe, Krotzer, Steven, Burke, Paul A., Sepp-Lorenzino, Laura, Bagchi, Ansuman, Howell, Bonnie J.

“…In this paper we describe a semiautomatic Cryo-Electron Microscopy image analysis framework to facilitate biophysical analysis of lipid nanoparticles carrying…”
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Advancing Polymeric Delivery Systems Amidst a Nucleic Acid Therapy Renaissance by Burke, Paul A, Pun, Suzie H, Reineke, Theresa M

“…Nucleic acid therapeutics are attracting renewed interest due to recent clinical advances and product approvals. Most leading programs use chemical conjugates,…”
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Liver-targeted polymeric prodrugs delivered subcutaneously improve tafenoquine therapeutic window for malaria radical cure by Pottenger, Ayumi E, Roy, Debashish, Srinivasan, Selvi, Chavas, Thomas E J, Vlaskin, Vladmir, Ho, Duy-Khiet, Livingston, Vincent C, Maktabi, Mahdi, Lin, Hsiuling, Zhang, Jing, Pybus, Brandon, Kudyba, Karl, Roth, Alison, Senter, Peter, Tyson, George, Huber, Hans E, Wesche, David, Rochford, Rosemary, Burke, Paul A, Stayton, Patrick S

“…Approximately 3.3 billion people live with the threat of malaria. Infection can result in liver-localized hypnozoites, which when reactivated cause relapsing…”
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Improving protein therapeutics with sustained-release formulations by Putney, Scott D, Burke, Paul A

“…Although numerous protein therapeutics have been approved or are in advanced clinical testing, the development of more sophisticated delivery systems for this…”
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Atomizing into a chilled extraction solvent eliminates liquid gas from a spray-freeze drying microencapsulation process by Kennedy, Michael T, Ali-Reynolds, Alana, Farrier, Christina, Burke, Paul A

“…A spray-freeze drying encapsulation process using direct atomization into a chilled extraction solvent (ACES), in the absence of liquefied gas, was developed…”
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Protein powders for encapsulation: a comparison of spray-freeze drying and spray drying of darbepoetin alfa by Nguyen, Xichdao C, Herberger, John D, Burke, Paul A

“…To evaluate spray-freeze drying and spray drying processes for fabricating micron-sized particles of darbepoetin alfa (NESP, Aranesp) with uniform size…”
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Poly(lactide-co-glycolide) microsphere formulations of darbepoetin alfa: spray drying is an alternative to encapsulation by spray-freeze drying by Burke, Paul A, Klumb, Lisa A, Herberger, John D, Nguyen, Xichdao C, Harrell, Roy A, Zordich, Monica

“…The purpose of this work was to evaluate spray-freeze drying and spray drying processes for encapsulation of darbepoetin alfa (NESP, Aranesp). Darbepoetin alfa…”
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NMR Spectroscopic Evaluation of the Internal Environment of PLGA Microspheres by Wong-Moon, Kirby C, Sun, Xin, Nguyen, Xichdao C, Quan, Bin P, Shen, Kai, Burke, Paul A

“…The internal environment of poly(lactide-co-glycolide) (PLGA) microspheres was characterized using 31P and 13C solid-state and solution NMR spectroscopy…”
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Demonstration of structural integrity of an enzyme in organic solvents by solid-state NMR by Burke, Paul A, Smith, Steven O, Bachovchin, William W, Klibanov, Alexander M

“…High-resolution solid-state NMR spectroscopy with magic angle spinning (MAS) permits the measurement of isotropic chemical shifts in samples exhibiting…”
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Modeling electrolysis in reduced gravity: producing oxygen from in-situ resources at the moon and beyond by Burke, Paul A., Nord, Michael E., Hibbitts, Charles A., Berdis, Jodi R.

“…Molten Regolith Electrolysis, as an in situ resource utilization (ISRU) technology, has the potential to enable the production of oxygen and metallic alloys on…”
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Improving Issuer–Investor Communication in U.S. Securitization Transactions by Burke, Paul A., Morcom, Michael C.

“…The U.S. securitization market has been addressing many of the lessons learned from the financial crisis in an effort to rebuild the market in a more…”
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Solid-state NMR assessment of enzyme active center structure under nonaqueous conditions by BURKE, P. A, GRIFFIN, R. G, KLIBANOV, A. M

“…By using solid-state NMR spectroscopy, the integrity of the active center of alpha-chymotrypsin was investigated under a variety of nonaqueous conditions…”
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