Search Results - "Burke, M.Danny"

Bioflavonoids: selective substrates and inhibitors for cytochrome P450 CYP1A and CYP1B1 by Doostdar, Hamed, Burke, M.Danny, Mayer, Richard T

“…Interactions of six naturally occurring flavonoids (acacetin, diosmetin, eriodictyol, hesperetin, homoeriodictyol, and naringenin) with human cytochrome P450…”
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Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver by Burke, M D, Thompson, S, Weaver, R J, Wolf, C R, Mayer, R T

“…The O-dealkylations of ethoxyresorufin and pentoxyresorufin are widely used activity probes for measuring the cytochrome P450 forms, CYP1A1 and CYP2B1,…”
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Expression of cytochrome P450 CYP1B1 in breast cancer by McKay, Judith A., Melvin, William T., Ah-See, A.K., Ewen, Stanley W.B., Greenlee, William F., Marcus, Craig B., Burke, M.Danny, Murray, Graeme I.

“…The expression of CYP1B1 has been identified in breast cancer using the reverse transcriptase-polymerase chain reaction and immunoblotting. CYP1B1 mRNA was…”
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Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450 by Burke, M D, Thompson, S, Elcombe, C R, Halpert, J, Haaparanta, T, Mayer, R T

“…The individual members of a homologous series of phenoxazone ethers related to ethoxyresorufin were O-dealkylated, and the parent compound phenoxazone was…”
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A comparative study of constitutive and induced alkoxyresorufin O-dealkylation and individual cytochrome P450 forms in cynomolgus monkey (Macaca fascicularis), human, mouse, rat and hamster liver microsomes by Weaver, R J, Thompson, S, Smith, G, Dickins, M, Elcombe, C R, Mayer, R T, Burke, M D

“…The expression of constitutive and inducible cytochrome P450 forms was measured in cynomolgus monkey liver and compared with man, rat, mouse and hamster. Four…”
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Dealkylation of pentoxyresorufin: a rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics in the rat by Lubet, R A, Mayer, R T, Cameron, J W, Nims, R W, Burke, M D, Wolff, T, Guengerich, F P

“…The O-dealkylation of pentoxyresorufin (7-pentoxyphenoxazone) by rat liver microsomes was examined. The reaction appeared highly specific for certain…”
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Immunohistochemistry of drug-metabolizing enzymes by Murray, Graeme I., Burke, M.Danny

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Mixed function oxidase and UDP-glucuronyltransferase activities in the human Hep G2 hepatoma cell line by Grant, M H, Duthie, S J, Gray, A G, Burke, M D

“…In cultured human hepatoma cells phenolphthalein glucuronidation was increased 3-fold by 2 mM phenobarbitone (PB) in the culture medium but not by 25 microM…”
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Involvement of human cytochromes P450 (CYP) in the reductive metabolism of AQ4N, a hypoxia activated anthraquinone di-N-oxide prodrug by Raleigh, S M, Wanogho, E, Burke, M D, McKeown, S R, Patterson, L H

“…To establish the role of the human cytochromes P450 (CYPs) in the reductive metabolism of the novel anthraquinone di-N-oxide prodrug AQ4N. Metabolism of AQ4N…”
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Cytochrome P450 2C9 is responsible for hydroxylation of the naphthoquinone antimalarial drug 58C80 in human liver by Weaver, R J, Dickins, M, Burke, M D

“…2-(4-t-Butylcyclohexyl)-3-hydroxy-1,4-naphthoquinone (58C80) is an experimental naphthoquinone antimalarial drug which undergoes extensive alky hydroxylation…”
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Cytochrome P450 CYP3A5 in the human anterior pituitary gland by Murray, Graeme I., Pritchard, Stuart, Melvin, William T., Burke, M.Danny

“…The cytochromes P450 are a key group of enzymes involved in the metabolism of xenobiotics and several biologically active endogenous compounds. The expression…”
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Hydroxylation of the antimalarial drug 58C80 by CYP2C9 in human liver microsomes: Comparison with mephenytoin and tolbutamide hydroxylations by Weaver, Richard J., Dickins, Maurice, Burke, M.Danny

“…58C80 [2-(4- t-butylcyclohexyl)-3-hydroxy-1,4-naphthoquinone] is an experimental naphthoquinone antimalarial drug which undergoes extensive alkyl hydroxylation…”
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Cytochrome P450IA expression in adult and fetal human liver by Murray, G I, Foster, C O, Barnes, T S, Weaver, R J, Snyder, C P, Ewen, S W, Melvin, W T, Burke, M D

“…A monoclonal antibody has been produced that recognizes the cytochrome P450 form, cytochrome P450IA1, but not cytochrome P450IA2 in rats and recognizes a…”
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Human adult hepatocytes in primary monolayer culture. Maintenance of mixed function oxidase and conjugation pathways of drug metabolism by Grant, M H, Burke, M D, Hawksworth, G M, Duthie, S J, Engeset, J, Petrie, J C

“…The stabilities of several drug oxidation and conjugation pathways in human adult hepatocytes have been investigated during 72 hr culture. Cytochrome…”
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The effects of dimethylsulphoxide and 5-aminolaevulinic acid on the activities of cytochrome P450-dependent mixed function oxidase and UDP-glucuronosyl transferase activities in human Hep G2 hepatoma cells by Doostdar, H, Burke, M D, Melvin, W T, Grant, M H

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Evidence for a new cytochrome P450 form induced by 3-methylcholanthrene in rats by Weaver, R J, Dunbar, B, Dickins, M, Melvin, W T, Fothergill, J, Burke, M D

“…Evidence is presented for a new 3-methylcholanthrene (3MC)-induced form of cytochrome P450, P450MCX, in rat liver microsomes. P450MCX was co-purified with…”
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Amelioration of cyclosporin-induced nephrotoxicity in rats by induction of hepatic drug metabolism by Cunningham, C, Burke, M D, Wheatley, D N, Thomson, A W, Simpson, J G, Whiting, P H

“…The aim of this study was to determine the effect of altered hepatic drug metabolism on the nephrotoxic and immunosuppressive properties of cyclosporin A (CsA)…”
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Cytochrome P-450: a pharmacological necessity or a biochemical curiosity? by Burke, M D

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Metabolism of alkoxyphenoxazones by channel catfish liver microsomes: effects of phenobarbital, Aroclor 1254 and 3-methylcholanthrene by Ankley, G T, Reinert, R E, Mayer, R T, Burke, M D, Agosin, M

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Decreased hepatic microsomal cytochrome P450 due to indomethacin: protective roles of 16,16-dimethylprostaglandin F2 alpha and inducing agents by Burke, M D, Falzon, M, Milton, A S

“…Indomethacin administration to rats caused a dose-dependent decrease in hepatic microsomal cytochrome P450, aminopyrine N-demethylase, ethoxyresorufin…”
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