Search Results - "Burke, H"

FASTAptamer: A Bioinformatic Toolkit for High-throughput Sequence Analysis of Combinatorial Selections by Alam, Khalid K, Chang, Jonathan L, Burke, Donald H

“…High-throughput sequence (HTS) analysis of combinatorial selection populations accelerates lead discovery and optimization and offers dynamic insight into…”
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Inflammatory phenotyping predicts clinical outcome in COVID-19 by Burke, H, Freeman, A, Cellura, D C, Stuart, B L, Brendish, N J, Poole, S, Borca, F, Phan, H T T, Sheard, N, Williams, S, Spalluto, C M, Staples, K J, Clark, T W, Wilkinson, T M A

“…The COVID-19 pandemic has led to more than 760,000 deaths worldwide (correct as of 16th August 2020). Studies suggest a hyperinflammatory response is a major…”
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Cancer immunomodulation using bispecific aptamers by Thomas, Brian J., Porciani, David, Burke, Donald H.

“…Evasion of immune destruction is a major hallmark of cancer. Recent US Food and Drug Administration (FDA) approvals of various immunomodulating therapies…”
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Unravelling the mechanisms driving multimorbidity in COPD to develop holistic approaches to patient-centred care by Burke, H., Wilkinson, T.M.A.

“…COPD is a major cause of morbidity and mortality worldwide. Multimorbidity is common in COPD patients and a key modifiable factor, which requires timely…”
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Intraligand Charge Transfer Enables Visible‐Light‐Mediated Nickel‐Catalyzed Cross‐Coupling Reactions by Cavedon, Cristian, Gisbertz, Sebastian, Reischauer, Susanne, Vogl, Sarah, Sperlich, Eric, Burke, John H., Wallick, Rachel F., Schrottke, Stefanie, Hsu, Wei‐Hsin, Anghileri, Lucia, Pfeifer, Yannik, Richter, Noah, Teutloff, Christian, Müller‐Werkmeister, Henrike, Cambié, Dario, Seeberger, Peter H., Vura‐Weis, Josh, Veen, Renske M., Thomas, Arne, Pieber, Bartholomäus

“…We demonstrate that several visible‐light‐mediated carbon−heteroatom cross‐coupling reactions can be carried out using a photoactive NiII precatalyst that…”
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Selection and identification of an RNA aptamer that specifically binds the HIV-1 capsid lattice and inhibits viral replication by Gruenke, Paige R, Aneja, Rachna, Welbourn, Sarah, Ukah, Obiaara B, Sarafianos, Stefan G, Burke, Donald H, Lange, Margaret J

“…Abstract The HIV-1 capsid core participates in several replication processes. The mature capsid core is a lattice composed of capsid (CA) monomers thought to…”
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Modular cell-internalizing aptamer nanostructure enables targeted delivery of large functional RNAs in cancer cell lines by Porciani, David, Cardwell, Leah N., Tawiah, Kwaku D., Alam, Khalid K., Lange, Margaret J., Daniels, Mark A., Burke, Donald H.

“…Large RNAs and ribonucleoprotein complexes have powerful therapeutic potential, but effective cell-targeted delivery tools are limited. Aptamers that…”
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Spinal cord injury causes chronic bone marrow failure by Carpenter, Randall S., Marbourg, Jessica M., Brennan, Faith H., Mifflin, Katherine A., Hall, Jodie C. E., Jiang, Roselyn R., Mo, Xiaokui M., Karunasiri, Malith, Burke, Matthew H., Dorrance, Adrienne M., Popovich, Phillip G.

“…Spinal cord injury (SCI) causes immune dysfunction, increasing the risk of infectious morbidity and mortality. Since bone marrow hematopoiesis is essential for…”
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GS-CA Compounds: First-In-Class HIV-1 Capsid Inhibitors Covering Multiple Grounds by Singh, Kamal, Gallazzi, Fabio, Hill, Kyle J, Burke, Donald H, Lange, Margaret J, Quinn, Thomas P, Neogi, Ujjwal, Sönnerborg, Anders

“…Recently reported HIV-1 capsid (CA) inhibitors GS-CA1 and GS-6207 (an analog of GS-CA1) are first-in-class compounds with long-acting potential. Reportedly,…”
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Reduced health care-associated infections in an acute care community hospital using a combination of self-disinfecting copper-impregnated composite hard surfaces and linens by Sifri, Costi D., MD, Burke, Gene H., MD, Enfield, Kyle B., MD, MS

“…Background The purpose of this study was to determine the effectiveness of copper-impregnated composite hard surfaces and linens in an acute care hospital to…”
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Tumor-Cell-Macrophage Fusion Cells as Liquid Biomarkers and Tumor Enhancers in Cancer by Manjunath, Yariswamy, Porciani, David, Mitchem, Jonathan B, Suvilesh, Kanve N, Avella, Diego M, Kimchi, Eric T, Staveley-O'Carroll, Kevin F, Burke, Donald H, Li, Guangfu, Kaifi, Jussuf T

“…Although molecular mechanisms driving tumor progression have been extensively studied, the biological nature of the various populations of circulating tumor…”
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Risk factors for persistent abnormality on chest radiographs at 12-weeks post hospitalisation with PCR confirmed COVID-19 by Wallis, T. J. M, Heiden, E, Horno, J, Welham, B, Burke, H, Freeman, A, Dexter, L, Fazleen, A, Kong, A, McQuitty, C, Watson, M, Poole, S, Brendish, N. J, Clark, T. W, Wilkinson, T. M. A, Jones, M. G, Marshall, B. G

“…Abstract Background The long-term consequences of COVID-19 remain unclear. There is concern a proportion of patients will progress to develop pulmonary…”
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Binding interface and impact on protease cleavage for an RNA aptamer to HIV-1 reverse transcriptase by Nguyen, Phuong D M, Zheng, Jie, Gremminger, Thomas J, Qiu, Liming, Zhang, Dong, Tuske, Steve, Lange, Margaret J, Griffin, Patrick R, Arnold, Eddy, Chen, Shi-Jie, Zou, Xiaoqin, Heng, Xiao, Burke, Donald H

“…Abstract RNA aptamers that bind HIV-1 reverse transcriptase (RT) inhibit RT in enzymatic and viral replication assays. Some aptamers inhibit RT from only a few…”
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Dysregulated relationship of inflammation and oxidative stress in major depression by Rawdin, B.J, Mellon, S.H, Dhabhar, F.S, Epel, E.S, Puterman, E, Su, Y, Burke, H.M, Reus, V.I, Rosser, R, Hamilton, S.P, Nelson, J.C, Wolkowitz, O.M

“…Highlight ► The relationship of inflammation to oxidation may be disturbed in untreated major depression; this may reflect or contribute to increased risk of…”
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Flat detector CT and its applications in the endovascular treatment of wide-necked intracranial aneurysms—A literature review by Zwarzany, Łukasz, Poncyljusz, Wojciech, Burke, Thomas H

“…Highlights • FDCT provides cross-sectional images of the intraluminal devices. • Contrast agent administration enables the evaluation of the surrounding…”
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Development of Nanomaterial-Modified Impedimetric Aptasensor—A Single-Step Strategy for 3,4-Methylenedioxymethylamphetamine Detection by Soni, Shringika, Jain, Utkarsh, Burke, Donald H., Chauhan, Nidhi

“…Developing rapid, sensitive detection methods for 3,4-Methylenedioxymethylamphetamine (MDMA) is crucial to reduce its current misuse in the world population…”
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EGFL7 Antagonizes NOTCH Signaling and Represents a Novel Therapeutic Target in Acute Myeloid Leukemia by Bill, Marius, Pathmanathan, Aparna, Karunasiri, Malith, Shen, Changxian, Burke, Matthew H, Ranganathan, Parvathi, Papaioannou, Dimitrios, Zitzer, Nina C, Snyder, Katiri, LaRocco, Allison, Walker, Allison E, Brannan, Zachary J, Nalin, Ansel P, Freud, Aharon G, Dikov, Mikhail M, Zhang, Xiaoli, Bloomfield, Clara D, Garzon, Ramiro, Dorrance, Adrienne M

“…EGF-like domain 7 (EGFL7) is a secreted protein and recently has been shown to play an important role in acute myeloid leukemia (AML); however, the underlying…”
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Targeting lung cancer with clinically relevant EGFR mutations using anti-EGFR RNA aptamer by Thomas, Brian J., Guldenpfennig, Caitlyn, Guan, Yue, Winkler, Calvin, Beecher, Margaret, Beedy, Michaela, Berendzen, Ashley F., Ma, Lixin, Daniels, Mark A., Burke, Donald H., Porciani, David

“…A significant fraction of non-small cell lung cancer (NSCLC) cases are due to oncogenic mutations in the tyrosine kinase domain of the epidermal growth factor…”
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The LVIS/LVIS Jr. stents in the treatment of wide-neck intracranial aneurysms: multicentre registry by Poncyljusz, Wojciech, Biliński, Piotr, Safranow, Krzysztof, Baron, Jan, Zbroszczyk, Miłosz, Jaworski, Maciej, Bereza, Sławomir, Burke, Thomas H

“…Wide-necked intracranial aneurysms have been a challenge for endovascular techniques. With the advent of adjunctive devices such as balloons or stents,…”
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Low-profile Visualized Intraluminal Support device (LVIS Jr) as a novel tool in the treatment of wide-necked intracranial aneurysms: initial experience in 32 cases by Behme, Daniel, Weber, Anushe, Kowoll, Annika, Berlis, Ansgar, Burke, Thomas H, Weber, Werner

“…The focus of this study was to determine ease of deployment, safety and effectiveness of the LVIS Jr device. A retrospective analysis was performed of 32 cases…”
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