Search Results - "Burke, Amy C"

Citrus Flavonoids as Regulators of Lipoprotein Metabolism and Atherosclerosis by Mulvihill, Erin E, Burke, Amy C, Huff, Murray W

“…Citrus flavonoids are polyphenolic compounds with significant biological properties. This review summarizes recent advances in understanding the ability of…”
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Intervention with citrus flavonoids reverses obesity and improves metabolic syndrome and atherosclerosis in obese Ldlr−/− mice by Burke, Amy C., Sutherland, Brian G., Telford, Dawn E., Morrow, Marisa R., Sawyez, Cynthia G., Edwards, Jane Y., Drangova, Maria, Huff, Murray W.

“…Obesity and its associated metabolic dysfunction and cardiovascular disease risk represent a leading cause of adult morbidity worldwide. Currently available…”
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The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK[S] by Morrow, Nadya M., Burke, Amy C., Samsoondar, Joshua P., Seigel, Kyle E., Wang, Andrew, Telford, Dawn E., Sutherland, Brian G., O'Dwyer, Conor, Steinberg, Gregory R., Fullerton, Morgan D., Huff, Murray W.

“…Obesity, dyslipidemia, and insulin resistance, the increasingly common metabolic syndrome, are risk factors for CVD and type 2 diabetes that warrant novel…”
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Naringenin Prevents Obesity, Hepatic Steatosis, and Glucose Intolerance in Male Mice Independent of Fibroblast Growth Factor 21 by Assini, Julia M, Mulvihill, Erin E, Burke, Amy C, Sutherland, Brian G, Telford, Dawn E, Chhoker, Sanjiv S, Sawyez, Cynthia G, Drangova, Maria, Adams, Andrew C, Kharitonenkov, Alexei, Pin, Christopher L, Huff, Murray W

“…The molecular mechanisms and metabolic pathways whereby the citrus flavonoid, naringenin, reduces dyslipidemia and improves glucose tolerance were investigated…”
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ATP-citrate lyase: genetics, molecular biology and therapeutic target for dyslipidemia by Burke, Amy C, Huff, Murray W

“…ATP-citrate lyase (ACLY) has re-emerged as a drug target for LDL cholesterol (LDL-C) lowering. We review ACLY as a therapeutic strategy, its genetics, its…”
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Bempedoic acid: effects on lipoprotein metabolism and atherosclerosis by Burke, Amy C, Telford, Dawn E, Huff, Murray W

“…Bempedoic acid has emerged as a potent inhibitor of ATP-citrate lyase (ACLY), a target for the reduction of LDL cholesterol (LDL-C). We review the impact of…”
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PCSK9: Regulation and Target for Drug Development for Dyslipidemia by Burke, Amy C, Dron, Jacqueline S, Hegele, Robert A, Huff, Murray W

“…Proprotein convertase subtilisin kexin type-9 (PCSK9) is a secreted zymogen expressed primarily in the liver. PCSK9 circulates in plasma, binds to cell surface…”
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Regression of atherosclerosis: lessons learned from genetically modified mouse models by Burke, Amy C, Huff, Murray W

“…Regression, or reversal, of atherosclerosis has become an important clinical objective. The development of consistent models of murine atherosclerosis…”
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Prevention of Diet-Induced Metabolic Dysregulation, Inflammation, and Atherosclerosis in Ldlr−/− Mice by Treatment With the ATP-Citrate Lyase Inhibitor Bempedoic Acid by Samsoondar, Joshua P, Burke, Amy C, Sutherland, Brian G, Telford, Dawn E, Sawyez, Cynthia G, Edwards, Jane Y, Pinkosky, Stephen L, Newton, Roger S, Huff, Murray W

“…OBJECTIVE—Bempedoic acid (ETC-1002, 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid) is a novel low-density lipoprotein cholesterol–lowering compound. In…”
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Regulation of Stress Granule Formation by Inflammation, Vascular Injury, and Atherosclerosis by Herman, Allison B, Silva Afonso, Milessa, Kelemen, Sheri E, Ray, Mitali, Vrakas, Christine N, Burke, Amy C, Scalia, Rosario G, Moore, Kathryn, Autieri, Michael V

“…OBJECTIVE:Stress granules (SGs) are dynamic cytoplasmic aggregates containing mRNA, RNA-binding proteins, and translation factors that form in response to…”
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Bempedoic Acid Lowers Low-Density Lipoprotein Cholesterol and Attenuates Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient (LDLR+/− and LDLR−/−) Yucatan Miniature Pigs by Burke, Amy C, Telford, Dawn E, Sutherland, Brian G, Edwards, Jane Y, Sawyez, Cynthia G, Barrett, P. Hugh R, Newton, Roger S, Pickering, J Geoffrey, Huff, Murray W

“…OBJECTIVE—Bempedoic acid (BemA; ETC-1002) is a novel drug that targets hepatic ATP-citrate lyase to reduce cholesterol biosynthesis. In phase 2 studies, BemA…”
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Naringenin Supplementation to a Chow Diet Enhances Energy Expenditure and Fatty Acid Oxidation, and Reduces Adiposity in Lean, Pair‐Fed Ldlr−/− Mice by Burke, Amy C., Telford, Dawn E., Edwards, Jane Y., Sutherland, Brian G., Sawyez, Cynthia G., Huff, Murray W.

“…Scope Naringenin is a citrus‐derived flavonoid that has potent lipid‐lowering and insulin‐sensitizing effects in obese mouse models of metabolic dysfunction…”
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Exploring the role of place in sex work through participant photography by Sitter, Kathleen C, Grittner, Alison L, Fritz, Taryn, Burke, Amy C, Ophus, Emily

“…In this article, the authors explore the place-based experiences of sex workers and how these experiences intersect with the juridical realm of sex work. The…”
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Naringenin enhances the regression of atherosclerosis induced by a chow diet in Ldlr−/− mice by Burke, Amy C., Sutherland, Brian G., Telford, Dawn E., Morrow, Marisa R., Sawyez, Cynthia G., Edwards, Jane Y., Huff, Murray W.

“…Naringenin is a citrus-derived flavonoid with lipid-lowering and insulin-sensitizing effects leading to athero-protection in Ldlr−/− mice fed a high-fat diet…”
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Supporting positive sexual health for persons with developmental disabilities: Stories about the right to love by Sitter, Kathleen C., Burke, Amy C., Ladhani, Sheliza, Mallay, Nicole

“…Accessible Summary This research is about the sexual rights of persons with developmental disabilities. For 12 months, nine adults with developmental…”
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Peroxisome Proliferator–Activated Receptor δ Agonist GW1516 Attenuates Diet-Induced Aortic Inflammation, Insulin Resistance, and Atherosclerosis in Low-Density Lipoprotein Receptor Knockout Mice by Bojic, Lazar A, Burke, Amy C, Chhoker, Sanjiv S, Telford, Dawn E, Sutherland, Brian G, Edwards, Jane Y, Sawyez, Cynthia G, Tirona, Rommel G, Yin, Hao, Pickering, J Geoffrey, Huff, Murray W

“…OBJECTIVE—The peroxisome proliferator–activated receptor (PPAR) δ regulates systemic lipid homeostasis and inflammation. However, the ability of PPARδ agonists…”
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Abstract 369: Naringenin Supplementation to a Chow Diet Reduces Plasma Lipids and Adiposity, and Suppresses Rer In Ldlr -/- Mice Fed a Chow Diet by Burke, Amy C, Telford, Dawn E, Sutherland, Brian G, Edwards, Jane Y, Huff, Murray W

“…Abstract only Previously, we have shown that intervention by the addition of the citrus flavonoid naringenin to a chow diet enhances the reversal of…”
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Abstract 95: Naringenin Supplementation of a Low-Fat Diet Enhances the Reversal of Metabolic Dysfunction, Promotes Atherosclerosis Regression and Improves Lesion Pathology in Ldlr -/- Mice by Burke, Amy C, Sutherland, Brian G, Sawyez, Cynthia G, Telford, Dawn E, Huff, Murray W

“…Abstract only Diet-induced metabolic dysregulation (MetS) and atherosclerosis in mouse models can be reversed by intervention with a low-fat diet…”
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Abstract 686: Intervention with Naringenin Enhances Weight Loss, Potentiates Improvements in Metabolic Dysregulation and Halts Progression of Atherosclerosis Induced by a High-Fat Diet in LDLr-/- Mice by Burke, Amy C, Sutherland, Brian G, Assini, Julia M, Huff, Murray W

“…Abstract only Previous studies demonstrate that the addition of naringenin, a grapefruit flavonoid, to a high-fat diet prevents the development of many…”
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Abstract 394: Ldl-cholesterol, ApoB100 Kinetics and Atherosclerosis in Ldlr-deficient Yucatan Minipigs: A New Model for Familial Hypercholesterolemia by Telford, Dawn E, Burke, Amy C, Sutherland, Brian G, Sawyez, Cynthia G, Edwards, Jane Y, Barrett, P H, Newton, Roger S, Huff, Murray W

“…Abstract only Lack of animal models with human-like lipoprotein metabolism and pathology has hampered translational research in atherosclerosis. Recently, a…”
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