The level of embryonic antigens in the blood serum and cerebrospinal fluid of neuro-oncological patients

The levels of embryonic antigens (cancer embryonic antigen, alpha-fetoprotein, beta-chorionic gonadotropin were measured in the serum, spinal fluid, the cystic fluid of tumor 83 of neuro-oncological patients. It was found that the blood concentrations of cancer embryonic antigen and alpha-fetoprotei...

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Bibliographic Details
Published in:	Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko no. 3; p. 32
Main Authors:	Rudenko, V A, Lisianyĭ, N I, Grinevich, Iu A, Burkatovskaia, M B, Iugrinova, L G
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-07-1996
Subjects:	alpha-Fetoproteins - analysis Anaplasia - diagnosis Anaplasia - surgery Astrocytoma - diagnosis Astrocytoma - surgery Biomarkers, Tumor - analysis Brain - pathology Brain Neoplasms - diagnosis Brain Neoplasms - surgery Carcinoembryonic Antigen - analysis Chorionic Gonadotropin - analysis Glioblastoma - diagnosis Glioblastoma - surgery Humans Immunoenzyme Techniques - statistics & numerical data Intraoperative Period Postoperative Period Time Factors
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Summary:	The levels of embryonic antigens (cancer embryonic antigen, alpha-fetoprotein, beta-chorionic gonadotropin were measured in the serum, spinal fluid, the cystic fluid of tumor 83 of neuro-oncological patients. It was found that the blood concentrations of cancer embryonic antigen and alpha-fetoprotein were not generally related to the degree of malignancy and the blood level of beta-chorionic gonadotropin decreased with the higher degree of tumor anaplasia. The high content of beta-chorionic gonadotropin in the spinal fluid suggests its origin from a brain tumor. The fatal postoperative outcome was noted in patients having high preoperative serum levels of alpha-fetoprotein and cancer embryonic antigen with simultaneous much higher concentrations of alpha-fetoprotein in the serum than those in the spinal fluid.
ISSN:	0042-8817