Search Results - "Burk, Mark J."

Cell-Free Biosynthesis to Evaluate Lasso Peptide Formation and Enzyme–Substrate Tolerance by Si, Yuanyuan, Kretsch, Ashley M, Daigh, Laura M, Burk, Mark J, Mitchell, Douglas A

“…Lasso peptides are ribosomally synthesized and post-translationally modified peptide (RiPP) natural products that display a unique lariat-like, threaded…”
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Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol by Yim, Harry, Haselbeck, Robert, Niu, Wei, Pujol-Baxley, Catherine, Burgard, Anthony, Boldt, Jeff, Khandurina, Julia, Trawick, John D, Osterhout, Robin E, Stephen, Rosary, Estadilla, Jazell, Teisan, Sy, Schreyer, H Brett, Andrae, Stefan, Yang, Tae Hoon, Lee, Sang Yup, Burk, Mark J, Van Dien, Stephen

“…The design and implementation of a high-yielding enzymatic route to 1,4-butanediol—a compound not known to be produced naturally—provides a compelling example…”
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Development of a commercial scale process for production of 1,4-butanediol from sugar by Burgard, Anthony, Burk, Mark J, Osterhout, Robin, Van Dien, Stephen, Yim, Harry

“…Graphical abstract…”
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Development of an Efficient, Scalable, Aldolase-Catalyzed Process for Enantioselective Synthesis of Statin Intermediates by Greenberg, William A., Varvak, Alexander, Hanson, Sarah R., Wong, Kelvin, Huang, Hongjun, Chen, Pei, Burk, Mark J., Trost, Barry M.

“…A process is reported for efficient, enantioselective production of key intermediates for the common chiral side chain of statin-type cholesterol-lowering…”
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Biotechnology for Chemical Production: Challenges and Opportunities by Burk, Mark J, Van Dien, Stephen

“…Biotechnology offers a new sustainable approach to manufacturing chemicals, enabling the replacement of petroleum-based raw materials with renewable biobased…”
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Exploring Nitrilase Sequence Space for Enantioselective Catalysis by Robertson, Dan E, Chaplin, Jennifer A, DeSantis, Grace, Podar, Mircea, Madden, Mark, Chi, Ellen, Richardson, Toby, Milan, Aileen, Miller, Mark, Weiner, David P, Wong, Kelvin, McQuaid, Jeff, Farwell, Bob, Preston, Lori A, Tan, Xuqiu, Snead, Marjory A, Keller, Martin, Mathur, Eric, Kretz, Patricia L, Burk, Mark J, Short, Jay M

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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An Enzyme Library Approach to Biocatalysis:  Development of Nitrilases for Enantioselective Production of Carboxylic Acid Derivatives by DeSantis, Grace, Zhu, Zuolin, Greenberg, William A, Wong, Kelvin, Chaplin, Jenny, Hanson, Sarah R, Farwell, Bob, Nicholson, Lawrence W, Rand, Cynthia L, Weiner, David P, Robertson, Dan E, Burk, Mark J

“…The discovery, from Nature, of a large and diverse set of nitrilases is reported. The utility of this nitrilase library for identifying enzymes that catalyze…”
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Discovery of Pectin-degrading Enzymes and Directed Evolution of a Novel Pectate Lyase for Processing Cotton Fabric by Solbak, Arne I., Richardson, Toby H., McCann, Ryan T., Kline, Katie A., Bartnek, Flash, Tomlinson, Geoff, Tan, Xuqiu, Parra-Gessert, Lilian, Frey, Gerhard J., Podar, Mircea, Luginbühl, Peter, Gray, Kevin A., Mathur, Eric J., Robertson, Dan E., Burk, Mark J., Hazlewood, Geoffrey P., Short, Jay M., Kerovuo, Janne

“…There is a growing need in the textile industry for more economical and environmentally responsible approaches to improve the scouring process as part of the…”
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A Three-Step Procedure for Asymmetric Catalytic Reductive Amidation of Ketones by Burk, Mark J, Casy, Guy, Johnson, Nicholas B

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An Enantioselective Synthesis of (S)-(+)-3-Aminomethyl-5-methylhexanoic Acid via Asymmetric Hydrogenation by Burk, Mark J, de Koning, Pieter D, Grote, Todd M, Hoekstra, Marvin S, Hoge, Garrett, Jennings, Rex A, Kissel, William S, Le, Tung V, Lennon, Ian C, Mulhern, Thomas A, Ramsden, James A, Wade, Robert A

“…A concise enantioselective synthesis of (S)-(+)-3-aminomethyl-5-methylhexanoic acid (1, Pregabalin) has been developed. The key step is the asymmetric…”
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Epoxide Hydrolase-Catalyzed Enantioselective Synthesis of Chiral 1,2-Diols via Desymmetrization of meso-Epoxides by ZHAO, Lishan, HAN, Bin, HUANG, Zilin, MILLER, Mark, HUANG, Hongjun, MALASHOCK, Dan S., ZHU, Zuolin, MILAN, Aileen, ROBERTSON, Dan E., WEINER, David P., BURK, Mark J.

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Synthesis and Applications of HexaPHEMP, a Novel Biaryl Diphosphine Ligand by Henschke, Julian P., Burk, Mark J., Malan, Christophe G., Herzberg, Daniela, Peterson, Justine A., Wildsmith, Andrew J., Cobley, Christopher J., Casy, Guy

“…The novel biaryldiphosphine ligand 1 (HexaPHEMP) has been prepared in five steps from commercially available 3,4,5‐trimethylphenol using a concise synthetic…”
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Preparation and use of C2-symmetric bis(phospholanes): production of .alpha.-amino acid derivatives via highly enantioselective hydrogenation reactions by Burk, Mark J, Feaster, John E, Nugent, William A, Harlow, Richard L

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Substrate interactions guide cyclase engineering and lasso peptide diversification by Barrett, Susanna E, Yin, Song, Jordan, Peter, Brunson, John K, Gordon-Nunez, Jessica, Costa Machado da Cruz, Gabriella, Rosario, Christopher, Okada, Bethany K, Anderson, Kelsey, Pires, Thomas A, Wang, Ruoyang, Shukla, Diwakar, Burk, Mark J, Mitchell, Douglas A

“…Lasso peptides are a diverse class of naturally occurring, highly stable molecules kinetically trapped in a distinctive [1]rotaxane conformation. How the…”
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Enantioselective hydrogenation of the C:N group: a catalytic asymmetric reductive amination procedure by Burk, Mark J, Feaster, John E

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Highly Enantioselective Hydrogenation of .beta.-Keto Esters under Mild Conditions by Burk, Mark J, Harper, T. Gregory P, Kalberg, Christopher S

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integrated biotechnology platform for developing sustainable chemical processes by Barton, Nelson R, Burgard, Anthony P, Burk, Mark J, Crater, Jason S, Osterhout, Robin E, Pharkya, Priti, Steer, Brian A, Sun, Jun, Trawick, John D, Van Dien, Stephen J, Yang, Tae Hoon, Yim, Harry

“…Genomatica has established an integrated computational/experimental metabolic engineering platform to design, create, and optimize novel high performance…”
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Me-DuPHOS-Rh-Catalyzed Asymmetric Synthesis of the Pivotal Glutarate Intermediate for Candoxatril by Burk, Mark J, Bienewald, Frank, Challenger, Stephen, Derrick, Andrew, Ramsden, James A

“…A greatly improved process has been developed for synthesis of the glutarate derivative 2, a key intermediate required for Pfizer's drug candoxatril. The…”
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Creation of a Productive, Highly Enantioselective Nitrilase through Gene Site Saturation Mutagenesis (GSSM) by DeSantis, Grace, Wong, Kelvin, Farwell, Bob, Chatman, Kelly, Zhu, Zoulin, Tomlinson, Geoff, Huang, Hongjun, Tan, Xuqiu, Bibbs, Lisa, Chen, Pei, Kretz, Keith, Burk, Mark J

“…Gene site saturation mutagenesis (GSSM) technology is applied for the directed evolution of a nitrilase. The nitrilase effectively catalyzes the…”
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A Catalyst for Efficient and Highly Enantioselective Hydrogenation of Aromatic, Heteroaromatic, and α,β-Unsaturated Ketones by Burk, Mark J, Hems, William, Herzberg, Daniela, Malan, Christophe, Zanotti-Gerosa, Antonio

“…PhanePhos−ruthenium−diamine complexes catalyze the asymmetric hydrogenation of a wide range of aromatic, heteroaromatic, and α,β-unsaturated ketones with high…”
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