Search Results - "Buri, Michelle C."
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Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function
Published in Nature communications (20-08-2020)“…T cells engineered to express chimeric antigen receptors (CAR-T cells) have shown impressive clinical efficacy in the treatment of B cell malignancies…”
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A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations
Published in Nature communications (03-05-2024)“…Early childhood tumours arise from transformed embryonic cells, which often carry large copy number alterations (CNA). However, it remains unclear how CNAs…”
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BET protein inhibition sensitizes glioblastoma cells to temozolomide treatment by attenuating MGMT expression
Published in Cell death & disease (13-12-2022)“…Bromodomain and extra-terminal tail (BET) proteins have been identified as potential epigenetic targets in cancer, including glioblastoma. These epigenetic…”
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Epigenetic silencing of HTATIP2 in glioblastoma contributes to treatment resistance by enhancing nuclear translocation of the DNA repair protein MPG
Published in Molecular oncology (01-09-2023)“…Glioblastoma, the most malignant brain tumor in adults, exhibits characteristic patterns of epigenetic alterations that await elucidation. The DNA methylome of…”
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Abstract 3542: A stem cell model dissects detrimental effects of neuroblastoma-linked chromosomal aberrations on cell differentiation during neural crest development
Published in Cancer research (Chicago, Ill.) (04-04-2023)“…Early childhood malignancies are driven by sparse genetic aberrations in oncogenes that often co-occur with large copy number variants (CNVs). The combination…”
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