Search Results - "Burgraff, Nicholas J"

Dual mechanisms of opioid-induced respiratory depression in the inspiratory rhythm-generating network by Baertsch, Nathan A, Bush, Nicholas E, Burgraff, Nicholas J, Ramirez, Jan-Marino

“…The analgesic utility of opioid-based drugs is limited by the life-threatening risk of respiratory depression. Opioid-induced respiratory depression (OIRD),…”
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Purinergic signaling mediates neuroglial interactions to modulate sighs by Severs, Liza J., Bush, Nicholas E., Quina, Lely A., Hidalgo-Andrade, Skyler, Burgraff, Nicholas J., Dashevskiy, Tatiana, Shih, Andy Y., Baertsch, Nathan A., Ramirez, Jan-Marino

“…Sighs prevent the collapse of alveoli in the lungs, initiate arousal under hypoxic conditions, and are an expression of sadness and relief. Sighs are…”
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The Complexity of Fentanyl's Impact on Brain and Peripheral Oxygenation by Burgraff, Nicholas J

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Keeping breathing in balance through hormonal modulation in respiratory control by Burgraff, Nicholas J.

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Glutamate receptor plasticity in brainstem respiratory nuclei following chronic hypercapnia in goats by Burgraff, Nicholas J., Neumueller, Suzanne E., Buchholz, Kirstyn J., Hodges, Matthew R., Pan, Lawrence, Forster, Hubert V.

“…Patients that retain CO2 in respiratory diseases such as chronic obstructive pulmonary disease (COPD) have worse prognoses and higher mortality rates than…”
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A comparative examination of morphine and fentanyl: unravelling the differential impacts on breathing and airway stability by Burgraff, Nicholas J, Baertsch, Nathan A, Ramirez, Jan-Marino

“…This study provides an in-depth analysis of the distinct consequences of the opioid drugs morphine and fentanyl during opioid-induced respiratory depression…”
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Neuronal mechanisms underlying opioid-induced respiratory depression: our current understanding by Ramirez, Jan-Marino, Burgraff, Nicholas J, Wei, Aguan D, Baertsch, Nathan A, Varga, Adrienn G, Baghdoyan, Helen A, Lydic, Ralph, Morris, Kendall F, Bolser, Donald C, Levitt, Erica S

“…Opioid-induced respiratory depression (OIRD) represents the primary cause of death associated with therapeutic and recreational opioid use. Within the United…”
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Dynamic Rhythmogenic Network States Drive Differential Opioid Responses in the In Vitro Respiratory Network by Burgraff, Nicholas J, Bush, Nicholas E, Ramirez, Jan M, Baertsch, Nathan A

“…Death from opioid overdose is typically caused by opioid-induced respiratory depression (OIRD). A particularly dangerous characteristic of OIRD is its apparent…”
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Peptides, Breathing, and Sudden Infant Death Syndrome by Burgraff, Nicholas J., Baertsch, Nathan A., Ramirez, Jan-Marino

“…Shi et al. recently identified a brainstem peptidergic circuit in mice that is activated at birth and stabilizes breathing during the transition from the…”
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Inspiratory rhythm generation is stabilized by I h by Burgraff, Nicholas J, Phillips, Ryan S, Severs, Liza J, Bush, Nicholas E, Baertsch, Nathan A, Ramirez, Jan-Marino

“…Cellular and network properties must be capable of generating rhythmic activity that is both flexible and stable. This is particularly important for breathing,…”
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Chronic moderate hypercapnia suppresses ventilatory responses to acute CO2 challenges by Buchholz, Kirstyn J, Neumueller, Suzanne E, Burgraff, Nicholas J, Hodges, Matthew R, Pan, Lawrence, ster, Hubert V

“…Chronic hypercapnia (CH) is a hallmark of chronic lung disease, and CH increases the risk for acute-on-chronic exacerbations leading to greater…”
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Inspiratory rhythm generation is stabilized by Ih by Burgraff, Nicholas J, Phillips, Ryan S, Severs, Liza J, Bush, Nicholas E, Baertsch, Nathan A, Ramirez, Jan-Marino

“…Cellular and network properties must be capable of generating rhythmic activity that is both flexible and stable. This is particularly important for breathing,…”
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Ventilatory and integrated physiological responses to chronic hypercapnia in goats by Burgraff, Nicholas J., Neumueller, Suzanne E., Buchholz, Kirstyn, Langer, Thomas M., Hodges, Matthew R., Pan, Lawrence, Forster, Hubert V.

“…Key points Chronic hypercapnia per se has distinct effects on the mechanisms regulating steady‐state ventilation and the CO2/H+ chemoreflex. Chronic…”
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Temporal Dynamics and Therapeutic Implications of Phrenic Long-Term Facilitation in Respiratory Control by Bhagavan, Hemalatha, Burgraff, Nicholas J, Ramirez, Jan-Marino

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Brainstem serotonergic, catecholaminergic, and inflammatory adaptations during chronic hypercapnia in goats by Burgraff, Nicholas J., Neumueller, Suzanne E., Buchholz, Kirstyn J., LeClaire, John, Hodges, Matthew R., Pan, Lawrence, Forster, Hubert V.

“…Despite the prevalence of CO2 retention in human disease, little is known about the adaptive neurobiological effects of chronic hypercapnia. We have recently…”
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Physiological and neurochemical adaptations following abrupt termination of chronic hypercapnia in goats by Buchholz, Kirstyn J, Burgraff, Nicholas J, Neumueller, Suzanne E, Hodges, Matthew Robert, Pan, Lawrence G, Forster, Hubert V

“…Chronic hypercapnia (CH) is a hallmark of respiratory diseases such as chronic obstructive pulmonary disease. In such patients, mechanical ventilation is often…”
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Mild and moderate chronic hypercapnia elicit distinct transcriptomic responses of immune function in cardiorespiratory nuclei by Grams, Kirstyn J, Neumueller, Suzanne E, Mouradian, Jr, Gary C, Burgraff, Nicholas J, Hodges, Matthew R, Pan, Lawrence, Forster, Hubert V

“…Chronic hypercapnia (CH) is a hallmark of respiratory-related diseases, and the level of hypercapnia can acutely or progressively become more severe…”
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Midbrain and cerebral inflammatory and glutamatergic adaptations during chronic hypercapnia in goats by Burgraff, Nicholas J., Neumueller, Suzanne E., Buchholz, Kirstyn J., Hodges, Matthew R., Pan, Lawrence, Forster, Hubert V.

“…•Chronic hypercapnia transiently increases IL-1β in cognitive brain regions.•Chronic hypercapnia reduces GluR2 AMPA receptors in cognitive brain…”
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Effects on breathing of agonists to μ-opioid or GABA A receptors dialyzed into the ventral respiratory column of awake and sleeping goats by Langer, 3rd, Thomas M, Neumueller, Suzanne E, Crumley, Emma, Burgraff, Nicholas J, Talwar, Sawan, Hodges, Matthew R, Pan, Lawrence, Forster, Hubert V

“…Pulmonary ventilation (V̇ ) in awake and sleeping goats does not change when antagonists to several excitatory G protein-coupled receptors are dialyzed…”
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Effects on breathing of agonists to μ-opioid or GABAA receptors dialyzed into the ventral respiratory column of awake and sleeping goats by Langer, Thomas M, Neumueller, Suzanne E, Crumley, Emma, Burgraff, Nicholas J, Talwar, Sawan, Hodges, Matthew R, Pan, Lawrence, Forster, Hubert V

“…Highlights • Increased inhibitory receptor activity in the VRC alters & destabilizes breathing. • Changes occur in neuromodulators when inhibitory receptor…”
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