Search Results - "Burgin, Alex B."

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases by Park, Sung-Jun, Ahmad, Faiyaz, Philp, Andrew, Baar, Keith, Williams, Tishan, Luo, Haibin, Ke, Hengming, Rehmann, Holger, Taussig, Ronald, Brown, Alexandra L., Kim, Myung K., Beaven, Michael A., Burgin, Alex B., Manganiello, Vincent, Chung, Jay H.

“…Resveratrol, a polyphenol in red wine, has been reported as a calorie restriction mimetic with potential antiaging and antidiabetogenic properties. It is…”
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Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants by Brenan, Lisa, Andreev, Aleksandr, Cohen, Ofir, Pantel, Sasha, Kamburov, Atanas, Cacchiarelli, Davide, Persky, Nicole S., Zhu, Cong, Bagul, Mukta, Goetz, Eva M., Burgin, Alex B., Garraway, Levi A., Getz, Gad, Mikkelsen, Tarjei S., Piccioni, Federica, Root, David E., Johannessen, Cory M.

“…Tumor-specific genomic information has the potential to guide therapeutic strategies and revolutionize patient treatment. Currently, this approach is limited…”
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Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets by Davies, Douglas R, Gelinas, Amy D, Zhang, Chi, Rohloff, John C, Carter, Jeffrey D, O’Connell, Daniel, Waugh, Sheela M, Wolk, Steven K, Mayfield, Wesley S, Burgin, Alex B, Edwards, Thomas E, Stewart, Lance J, Gold, Larry, Janjic, Nebojsa, Jarvis, Thale C

“…Selection of aptamers from nucleic acid libraries by in vitro evolution represents a powerful method of identifying high-affinity ligands for a broad range of…”
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A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases by Deweese, Joseph E, Osheroff, Neil, Berger, James M, Schmidt, Bryan H, Burgin, Alex B

“…Type II topoisomerases are required for the management of DNA tangles and supercoils, and are targets of clinical antibiotics and anti-cancer agents. These…”
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Structural basis for the design of selective phosphodiesterase 4B inhibitors by Fox, David, Burgin, Alex B., Gurney, Mark E.

“…Phosphodiesterase-4B (PDE4B) regulates the pro-inflammatory Toll Receptor –Tumor Necrosis Factor α (TNFα) pathway in monocytes, macrophages and microglial…”
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The Mechanism of Topoisomerase I Poisoning by a Camptothecin Analog by Staker, Bart L., Hjerrild, Kathryn, Feese, Michael D., Behnke, Craig A., Burgin, Alex B., Stewart, Lance

“…We report the x-ray crystal structure of human topoisomerase I covalently joined to double-stranded DNA and bound to the clinically approved anticancer agent…”
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Artificial neural networks trained to detect viral and phage structural proteins by Seguritan, Victor, Alves, Jr, Nelson, Arnoult, Michael, Raymond, Amy, Lorimer, Don, Burgin, Jr, Alex B, Salamon, Peter, Segall, Anca M

“…Phages play critical roles in the survival and pathogenicity of their hosts, via lysogenic conversion factors, and in nutrient redistribution, via cell lysis…”
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Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent Complex by Staker, Bart L, Feese, Michael D, Cushman, Mark, Pommier, Yves, Zembower, David, Stewart, Lance, Burgin, Alex B

“…Human topoisomerase I (top1) is the molecular target of a diverse set of anticancer compounds, including the camptothecins, indolocarbazoles, and…”
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Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor by Jarvis, Thale C., Davies, Douglas R., Hisaminato, Akihiko, Resnicow, Daniel I., Gupta, Shashi, Waugh, Sheela M., Nagabukuro, Akira, Wadatsu, Takashi, Hishigaki, Haretsugu, Gawande, Bharat, Zhang, Chi, Wolk, Steven K., Mayfield, Wesley S., Nakaishi, Yuichiro, Burgin, Alex B., Stewart, Lance J., Edwards, Thomas E., Gelinas, Amy D., Schneider, Daniel J., Janjic, Nebojsa

“…Discerning the structural building blocks of macromolecules is essential for understanding their folding and function. For a new generation of modified nucleic…”
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Structure and function of a cyanophage-encoded peptide deformylase by Frank, Jeremy A, Lorimer, Don, Youle, Merry, Witte, Pam, Craig, Tim, Abendroth, Jan, Rohwer, Forest, Edwards, Robert A, Segall, Anca M, Burgin, Alex B

“…Bacteriophages encode auxiliary metabolic genes that support more efficient phage replication. For example, cyanophages carry several genes to maintain host…”
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A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1 by Clifton, Matthew C, Dranow, David M, Leed, Alison, Fulroth, Ben, Fairman, James W, Abendroth, Jan, Atkins, Kateri A, Wallace, Ellen, Fan, Dazhong, Xu, Guoping, Ni, Z J, Daniels, Doug, Van Drie, John, Wei, Guo, Burgin, Alex B, Golub, Todd R, Hubbard, Brian K, Serrano-Wu, Michael H

“…Crystallization of a maltose-binding protein MCL1 fusion has yielded a robust crystallography platform that generated the first apo MCL1 crystal structure, as…”
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A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex by Marchand, Christophe, Antony, Smitha, Kohn, Kurt W, Cushman, Mark, Ioanoviciu, Alexandra, Staker, Bart L, Burgin, Alex B, Stewart, Lance, Pommier, Yves

“…We show that five topoisomerase I inhibitors (two indenoisoquinolines, two camptothecins, and one indolocarbazole) each intercalate between the base pairs…”
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Mechanisms of Camptothecin Resistance by Human Topoisomerase I Mutations by Chrencik, Jill E, Staker, Bart L, Burgin, Alex B, Pourquier, Philippe, Pommier, Yves, Stewart, Lance, Redinbo, Matthew R

“…Human topoisomerase I relaxes superhelical tension associated with DNA replication, transcription and recombination by reversibly nicking one strand of duplex…”
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Substrate Specificity of Tyrosyl-DNA Phosphodiesterase I (Tdp1) by Raymond, Amy C., Staker, Bart L., Burgin, Alex B.

“…Tyrosyl-DNA phosphodiesterase I (Tdp1) hydrolyzes 3′-phosphotyrosyl bonds to generate 3′-phosphate DNA and tyrosine in vitro. Tdp1 is involved in the repair of…”
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Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety by Burgin, Alex B, Gurney, Mark E, Magnusson, Olafur T, Singh, Jasbir, Witte, Pam, Staker, Bart L, Bjornsson, Jon M, Thorsteinsdottir, Margret, Hrafnsdottir, Sigrun, Hagen, Timothy, Kiselyov, Alex S, Stewart, Lance J

“…Finding safe inhibitors of phosphodiesterase 4, the enzyme that breaks down cAMP, has been a longstanding goal in pharmaceutical development. Burgin et al …”
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Phosphodiesterase-4 (PDE4) Molecular Pharmacology and Alzheimer’s Disease by Gurney, Mark E., D’Amato, Emily C., Burgin, Alex B.

“…Between 20% and 25% of patients diagnosed with Alzheimer’s disease (AD) do not have amyloid burden as assessed by positron emission tomography imaging. Thus,…”
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Uncoupling the Chemical Steps of Telomere Resolution by ResT by Kobryn, Kerri, Burgin, Alex B., Chaconas, George

“…ResT is the telomere resolvase of the spirochete Borrelia burgdorferi, the causative agent of Lyme disease. ResT is an essential cellular function that…”
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Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics by de Waal, Luc, Lewis, Timothy A, Rees, Matthew G, Tsherniak, Aviad, Wu, Xiaoyun, Choi, Peter S, Gechijian, Lara, Hartigan, Christina, Faloon, Patrick W, Hickey, Mark J, Tolliday, Nicola, Carr, Steven A, Clemons, Paul A, Munoz, Benito, Wagner, Bridget K, Shamji, Alykhan F, Koehler, Angela N, Schenone, Monica, Burgin, Alex B, Schreiber, Stuart L, Greulich, Heidi, Meyerson, Matthew

“…Phenotypic screening in cancer cell lines combined with chemogenomics analysis reveals a correlation between DNMDP sensitivity and increased PDE3A expression…”
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Analysis of Human Tyrosyl-DNA Phosphodiesterase I Catalytic Residues by Raymond, Amy C., Rideout, Marc C., Staker, Bart, Hjerrild, Kathryn, Burgin, Alex B.

“…Tyrosyl-DNA phosphodiesterase I (Tdp1) is involved in the repair of DNA lesions created by topoisomerase I in vivo. Tdp1 is a member of the phospholipase D…”
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Substitution of Conserved Residues within the Active Site Alters the Cleavage Religation Equilibrium of DNA Topoisomerase I by Colley, William C., van der Merwe, Marie, Vance, John R., Burgin, Alex B., Bjornsti, Mary-Ann

“…Eukaryotic DNA topoisomerase I (Top1p) catalyzes the relaxation of supercoiled DNA and constitutes the cellular target of camptothecin (CPT). Mutation of…”
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