Search Results - "Burgin, A B"

A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases by Yang, S.W. (National Institute of Mental Health, Bethesda, MD.), Burgin, A.B. Jr, Huizenga, B.N, Robertson, C.A, Yao, K.C, Nash, H.A

“…The covalent joining of topoisomerases to DNA is normally a transient step in the reaction cycle of these important enzymes. However, under a variety of…”
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Mapping the active site of ribonuclease P RNA using a substrate containing a photoaffinity agent by Burgin, A. B., Pace, N. R.

“…Ribonuclease P RNA is the catalytic moiety of the ribonucleoprotein enzyme that removes precursor sequences from 5′‐ends of pre‐tRNAs. A photoaffinity…”
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A novel suicide substrate for DNA topoisomerases and site-specific recombinases by Burgin, Alex B., Huizenga, Beth N., Nash, Howard A.

“…DNA topoisomerases and DNA site-specific recombinases are biologically important enzymes involved in a diverse set of cellular processes. We show that…”
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Influence of metal ions on the ribonuclease P reaction. Distinguishing substrate binding from catalysis by Smith, D, Burgin, A B, Haas, E S, Pace, N R

“…A high yield, photoactivated cross-linking reaction between a modified tRNA and RNase P RNA was used as a quantitative assay of substrate binding affinity. The…”
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Chemically Modified Hammerhead Ribozymes with Improved Catalytic Rates by Burgin, Alex B, Gonzalez, Carolyn, Matulic-Adamic, Jasenka, Karpeisky, Alexander M, Usman, Nassim, McSwiggen, James A, Beigelman, Leonid

“…A site-specific chemical modification strategy has been employed to elucidate structure−function relationships at the only phylogenetically nonconserved…”
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Can DNA Topoisomerases Be Ribonucleases? by Burgin, Alex B.

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The Mechanism of Topoisomerase I Poisoning by a Camptothecin Analog by Staker, Bart L., Hjerrild, Kathryn, Feese, Michael D., Behnke, Craig A., Burgin, Alex B., Stewart, Lance

“…We report the x-ray crystal structure of human topoisomerase I covalently joined to double-stranded DNA and bound to the clinically approved anticancer agent…”
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The excision of intervening sequences from Salmonella 23S ribosomal RNA by Burgin, A B, Parodos, K, Lane, D J, Pace, N R

“…Novel, approximately 90 bp intervening sequences (IVs) were discovered within the 23S rRNA genes of S. typhimurium and S. arizonae. These non-rRNA sequences…”
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Suicide substrates reveal properties of the homology-dependent steps during integrative recombination of bacteriophage λ by Burgin,Jr, Alex B., Nash, Howard A.

“…Background: A fundamental feature of bacteriophage λ site-specific recombination is the strict requirement for a region of sequence identity between…”
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Symmetry in the Mechanism of Bacteriophage λ Integrative Recombination by Burgin, Alex B., Nash, Howard A.

“…During the strand-exchange events of bacteriophage λ integration, pairs of phosphodiester bonds are broken and then rejoined to form novel DNA linkages. The…”
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Synthesis and use of DNA containing a 5'-bridging phosphorothioate as a suicide substrate for type I DNA topoisomerases by Burgin, A B

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The Scale of Demographic Heterogeneity in a Population of Peromyscus leucopus by KROHNE, D. T, BURGIN, A. B

“…The patterns of spatial heterogeneity in density and demography were studied in a population of Peromyscus leucopus inhabiting a deciduous forest in…”
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Analysis of Human Tyrosyl-DNA Phosphodiesterase I Catalytic Residues by Raymond, Amy C., Rideout, Marc C., Staker, Bart, Hjerrild, Kathryn, Burgin, Alex B.

“…Tyrosyl-DNA phosphodiesterase I (Tdp1) is involved in the repair of DNA lesions created by topoisomerase I in vivo. Tdp1 is a member of the phospholipase D…”
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Vaccinia topoisomerase and Cre recombinase catalyze direct ligation of activated DNA substrates containing a 3'-para-nitrophenyl phosphate ester by Woodfield, G, Cheng, C, Shuman, S, Burgin, A B

“…DNA topoisomerases and DNA site-specific recombinases are involved in a diverse set of cellular processes but both function by making transient breaks in DNA…”
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Plasmid RK2 ParB Protein: Purification and Nuclease Properties by Johnson, E P, Mincer, T, Schwab, H, Burgin, A B, Helinski, D R

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV by Pitts, Steven L., Liou, Grace F., Mitchenall, Lesley A., Burgin, Alex B., Maxwell, Anthony, Neuman, Keir C., Osheroff, Neil

“…It has long been known that type II topoisomerases require divalent metal ions in order to cleave DNA. Kinetic, mutagenesis and structural studies indicate…”
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Phosphodiesterase-4 (PDE4) Molecular Pharmacology and Alzheimer’s Disease by Gurney, Mark E., D’Amato, Emily C., Burgin, Alex B.

“…Between 20% and 25% of patients diagnosed with Alzheimer’s disease (AD) do not have amyloid burden as assessed by positron emission tomography imaging. Thus,…”
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Human topoisomerase II  uses a two-metal-ion mechanism for DNA cleavage by Deweese, J. E., Burgin, A. B., Osheroff, N.

“…The DNA cleavage reaction of human topoisomerase IIα is critical to all of the physiological and pharmacological functions of the protein. While it has long…”
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Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent Complex by Staker, Bart L, Feese, Michael D, Cushman, Mark, Pommier, Yves, Zembower, David, Stewart, Lance, Burgin, Alex B

“…Human topoisomerase I (top1) is the molecular target of a diverse set of anticancer compounds, including the camptothecins, indolocarbazoles, and…”
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Discovery of triazines as selective PDE4B versus PDE4D inhibitors by Hagen, Timothy J., Mo, Xuesheng, Burgin, Alex B., Fox, David, Zhang, Zheng, Gurney, Mark E.

“…In this study we report a series of triazine derivatives that are potent inhibitors of PDE4B. We also provide a series of structure activity relationships that…”
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