Search Results - "Burgess, Stephen"

A comparison of robust Mendelian randomization methods using summary data by Slob, Eric A. W., Burgess, Stephen

“…The number of Mendelian randomization (MR) analyses including large numbers of genetic variants is rapidly increasing. This is due to the proliferation of…”
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Combining information on multiple instrumental variables in Mendelian randomization: comparison of allele score and summarized data methods by Burgess, Stephen, Dudbridge, Frank, Thompson, Simon G.

“…Mendelian randomization is the use of genetic instrumental variables to obtain causal inferences from observational data. Two recent developments for combining…”
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Pleiotropy robust methods for multivariable Mendelian randomization by Grant, Andrew J., Burgess, Stephen

“…Mendelian randomization is a powerful tool for inferring the presence, or otherwise, of causal effects from observational data. However, the nature of genetic…”
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Selecting likely causal risk factors from high-throughput experiments using multivariable Mendelian randomization by Zuber, Verena, Colijn, Johanna Maria, Klaver, Caroline, Burgess, Stephen

“…Modern high-throughput experiments provide a rich resource to investigate causal determinants of disease risk. Mendelian randomization (MR) is the use of…”
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Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies by Larsson, Susanna C, Burgess, Stephen

“…Obesity is a worldwide epidemic that has been associated with a plurality of diseases in observational studies. The aim of this study was to summarize the…”
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A review of instrumental variable estimators for Mendelian randomization by Burgess, Stephen, Small, Dylan S, Thompson, Simon G

“…Instrumental variable analysis is an approach for obtaining causal inferences on the effect of an exposure (risk factor) on an outcome from observational data…”
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Bias due to participant overlap in two-sample Mendelian randomization by Burgess, Stephen, Davies, Neil M., Thompson, Simon G.

“…ABSTRACT Mendelian randomization analyses are often performed using summarized data. The causal estimate from a one‐sample analysis (in which data are taken…”
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Mendelian Randomization Implicates High-Density Lipoprotein Cholesterol–Associated Mechanisms in Etiology of Age-Related Macular Degeneration by Burgess, Stephen, MMath, PhD, Davey Smith, George, MD, DSc

“…Purpose Undertake a systematic investigation into associations between genetic predictors of lipid fractions and age-related macular degeneration (AMD) risk…”
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Inferring Causal Relationships Between Risk Factors and Outcomes from Genome-Wide Association Study Data by Burgess, Stephen, Foley, Christopher N, Zuber, Verena

“…An observational correlation between a suspected risk factor and an outcome does not necessarily imply that interventions on levels of the risk factor will…”
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Examining the Simple View of Reading With Elementary School Children: Still Simple After All These Years by Lonigan, Christopher J., Burgess, Stephen R., Schatschneider, Christopher

“…The simple view of reading (SVR) proposes that performance in reading comprehension is the result of decoding and linguistic comprehension, and that each…”
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PhenoScanner V2: an expanded tool for searching human genotype–phenotype associations by Kamat, Mihir A, Blackshaw, James A, Young, Robin, Surendran, Praveen, Burgess, Stephen, Danesh, John, Butterworth, Adam S, Staley, James R

“…Abstract Summary PhenoScanner is a curated database of publicly available results from large-scale genetic association studies in humans. This online tool…”
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Extending the MR‐Egger method for multivariable Mendelian randomization to correct for both measured and unmeasured pleiotropy by Rees, Jessica M. B., Wood, Angela M., Burgess, Stephen

“…Methods have been developed for Mendelian randomization that can obtain consistent causal estimates while relaxing the instrumental variable assumptions. These…”
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The evolution of mendelian randomization for investigating drug effects by Gill, Dipender, Burgess, Stephen

“…Dipender Gill and Stephen Burgess discuss the accompanying study by James Yarmolinsky and colleagues investigating the associations between genetically-proxied…”
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Appraising the causal role of smoking in multiple diseases: A systematic review and meta-analysis of Mendelian randomization studies by Larsson, Susanna C., Burgess, Stephen

“…The causal association between cigarette smoking and several diseases remains equivocal. The purpose of this study was to appraise the causal role of smoking…”
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A robust and efficient method for Mendelian randomization with hundreds of genetic variants by Burgess, Stephen, Foley, Christopher N, Allara, Elias, Staley, James R, Howson, Joanna M. M.

“…Mendelian randomization (MR) is an epidemiological technique that uses genetic variants to distinguish correlation from causation in observational data. The…”
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Hydraulic Redistribution in Three Amazonian Trees by Oliveira, Rafael S., Dawson, Todd E., Burgess, Stephen S. O., Nepstad, Daniel C.

“…About half of the Amazon rainforest is subject to seasonal droughts of 3 months or more. Despite this drought, several studies have shown that these forests,…”
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Body mass index and body composition in relation to 14 cardiovascular conditions in UK Biobank: a Mendelian randomization study by Larsson, Susanna C, Bäck, Magnus, Rees, Jessica M B, Mason, Amy M, Burgess, Stephen

“…Abstract Aims The causal role of adiposity for several cardiovascular diseases (CVDs) is unclear. Our primary aim was to apply the Mendelian randomization…”
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Hydraulic constraints modify optimal photosynthetic profiles in giant sequoia trees by Ambrose, Anthony R., Baxter, Wendy L., Wong, Christopher S., Burgess, Stephen S. O., Williams, Cameron B., Næsborg, Rikke R., Koch, George W., Dawson, Todd E.

“…Optimality theory states that whole-tree carbon gain is maximized when leaf N and photosynthetic capacity profiles are distributed along vertical light…”
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Smoking and stroke: A mendelian randomization study by Larsson, Susanna C., Burgess, Stephen, Michaëlsson, Karl

“…We used the Mendelian randomization design to explore the potential causal association of smoking with ischemic stroke and intracerebral hemorrhage using…”
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PhenoScanner: a database of human genotype-phenotype associations by Staley, James R, Blackshaw, James, Kamat, Mihir A, Ellis, Steve, Surendran, Praveen, Sun, Benjamin B, Paul, Dirk S, Freitag, Daniel, Burgess, Stephen, Danesh, John, Young, Robin, Butterworth, Adam S

“…PhenoScanner is a curated database of publicly available results from large-scale genetic association studies. This tool aims to facilitate 'phenome scans',…”
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