Search Results - "Burgers, Peter M"

RNase H2-Initiated Ribonucleotide Excision Repair by Sparks, Justin L., Chon, Hyongi, Cerritelli, Susana M., Kunkel, Thomas A., Johansson, Erik, Crouch, Robert J., Burgers, Peter M.

“…Ribonucleotides are incorporated into DNA by the replicative DNA polymerases at frequencies of about 2 per kb, which makes them by far the most abundant form…”
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Polymerase Dynamics at the Eukaryotic DNA Replication Fork by Burgers, Peter M.J.

“…This review discusses recent insights in the roles of DNA polymerases (Pol) δ and ∊ in eukaryotic DNA replication. A growing body of evidence specifies Pol ∊…”
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Eukaryotic DNA Replication Fork by Burgers, Peter M.J, Kunkel, Thomas A

“…This review focuses on the biogenesis and composition of the eukaryotic DNA replication fork, with an emphasis on the enzymes that synthesize DNA and repair…”
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Error-free and mutagenic processing of topoisomerase 1-provoked damage at genomic ribonucleotides by Sparks, Justin L, Burgers, Peter M

“…Genomic ribonucleotides incorporated during DNA replication are commonly repaired by RNase H2‐dependent ribonucleotide excision repair (RER). When RNase H2 is…”
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Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machinery by Kumar, Sandeep, Burgers, Peter M

“…Initiation of the DNA replication checkpoint in yeast is mainly mediated by Mec1 protein kinase, the ortholog of human ATR, while its homolog Tel1, the…”
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RNase H and Postreplication Repair Protect Cells from Ribonucleotides Incorporated in DNA by Lazzaro, Federico, Novarina, Daniele, Amara, Flavio, Watt, Danielle L., Stone, Jana E., Costanzo, Vincenzo, Burgers, Peter M., Kunkel, Thomas A., Plevani, Paolo, Muzi-Falconi, Marco

“…The chemical identity and integrity of the genome is challenged by the incorporation of ribonucleoside triphosphates (rNTPs) in place of deoxyribonucleoside…”
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A DNA damage–induced phosphorylation circuit enhances Mec1ATR Ddc2ATRIP recruitment to Replication Protein A by Yates, Luke A, Tannous, Elias A, Morgan, R Marc, Burgers, Peter M, Zhang, Xiaodong

“…The cell cycle checkpoint kinase Mec1ATR and its integral partner Ddc2ATRIP are vital for the DNA damage and replication stress response. Mec1–Ddc2 "senses"…”
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Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases by Nick McElhinny, Stephanie A, Watts, Brian E, Kumar, Dinesh, Watt, Danielle L, Lundström, Else-Britt, Burgers, Peter M.J, Johansson, Erik, Chabes, Andrei, Kunkel, Thomas A

“…Measurements of nucleoside triphosphate levels in Saccharomyces cerevisiae reveal that the four rNTPs are in 36- to 190-fold molar excess over their…”
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A Redox Role for the [4Fe4S] Cluster of Yeast DNA Polymerase δ by Bartels, Phillip L, Stodola, Joseph L, Burgers, Peter M. J, Barton, Jacqueline K

“…A [4Fe4S]2+ cluster in the C-terminal domain of the catalytic subunit of the eukaryotic B-family DNA polymerases is essential for the formation of active…”
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The Checkpoint Clamp Activates Mec1 Kinase during Initiation of the DNA Damage Checkpoint by Majka, Jerzy, Niedziela-Majka, Anita, Burgers, Peter M.J.

“…Yeast Mec1/Ddc2 protein kinase, the ortholog of human ATR/ATRIP, plays a central role in the DNA damage checkpoint. The PCNA-like clamp Rad17/Mec3/Ddc1 (the…”
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The Unstructured C-Terminal Tail of the 9-1-1 Clamp Subunit Ddc1 Activates Mec1/ATR via Two Distinct Mechanisms by Navadgi-Patil, Vasundhara M., Burgers, Peter M.

“…DNA damage checkpoint pathways operate to prevent cell-cycle progression in response to DNA damage and replication stress. In S. cerevisiae, Mec1-Ddc2 (human…”
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Ubiquitinated Proliferating Cell Nuclear Antigen Activates Translesion DNA Polymerases η and REV1 by Parie Garg, Peter M. Burgers, Hurwitz, Jerard

“…In response to DNA damage, the Rad6/Rad18 ubiquitin-conjugating complex monoubiquitinates the replication clamp proliferating cell nuclear antigen (PCNA) at…”
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Yet another job for Dna2: Checkpoint activation by Wanrooij, Paulina H., Burgers, Peter M.

“…Mec1 (ATR in humans) is the principal kinase responsible for checkpoint activation in response to replication stress and DNA damage in Saccharomyces…”
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Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly by Lydeard, John R, Lipkin-Moore, Zachary, Sheu, Yi-Jun, Stillman, Bruce, Burgers, Peter M, Haber, James E

“…Break-induced replication (BIR) is an efficient homologous recombination (HR) pathway employed to repair a DNA double-strand break (DSB) when homology is…”
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The fidelity of DNA replication, particularly on GC-rich templates, is reduced by defects of the Fe–S cluster in DNA polymerase δ by Kiktev, Denis A, Dominska, Margaret, Zhang, Tony, Dahl, Joseph, Stepchenkova, Elena I, Mieczkowski, Piotr, Burgers, Peter M, Lujan, Scott, Burkholder, Adam, Kunkel, Thomas A, Petes, Thomas D

“…Abstract Iron-sulfur clusters (4Fe–4S) exist in many enzymes concerned with DNA replication and repair. The contribution of these clusters to enzymatic…”
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Yeast DNA Replication Protein Dpb11 Activates the Mec1/ATR Checkpoint Kinase by Navadgi-Patil, Vasundhara M., Burgers, Peter M.

“…The Saccharomyces cerevisiae Mec1-Ddc2 protein kinase (human ATR-ATRIP) initiates a signal transduction pathway in response to DNA damage and replication…”
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Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations by Kochenova, Olga V, Bezalel-Buch, Rachel, Tran, Phong, Makarova, Alena V, Chabes, Andrei, Burgers, Peter M J, Shcherbakova, Polina V

“…In yeast, dNTP pools expand drastically during DNA damage response. We show that similar dNTP elevation occurs in strains, in which intrinsic replisome defects…”
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Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes by Netz, Daili J A, Stith, Carrie M, Stümpfig, Martin, Köpf, Gabriele, Vogel, Daniel, Genau, Heide M, Stodola, Joseph L, Lill, Roland, Burgers, Peter M J, Pierik, Antonio J

“…DNA polymerases contain two cysteine-rich metal binding motifs (CysA and CysB), which have been assigned as zinc-ion binding sites by structural studies. A…”
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A Ubiquitin-binding Motif in the Translesion DNA Polymerase Rev1 Mediates Its Essential Functional Interaction with Ubiquitinated Proliferating Cell Nuclear Antigen in Response to DNA Damage by Wood, Adam, Garg, Parie, Burgers, Peter M.J.

“…During normal DNA replication, the proliferating cell nuclear antigen (PCNA) enhances the processivity of DNA polymerases at the replication fork. When DNA…”
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Flexibility of Eukaryotic Okazaki Fragment Maturation through Regulated Strand Displacement Synthesis by Stith, Carrie M., Sterling, Joan, Resnick, Michael A., Gordenin, Dmitry A., Burgers, Peter M.

“…Okazaki fragment maturation to produce continuous lagging strands in eukaryotic cells requires precise coordination of strand displacement synthesis by DNA…”
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