Search Results - "Burgering, Boudewijn M"

Interplay between metabolic identities in the intestinal crypt supports stem cell function by Rodríguez-Colman, Maria J., Schewe, Matthias, Meerlo, Maaike, Stigter, Edwin, Gerrits, Johan, Pras-Raves, Mia, Sacchetti, Andrea, Hornsveld, Marten, Oost, Koen C., Snippert, Hugo J., Verhoeven-Duif, Nanda, Fodde, Riccardo, Burgering, Boudewijn M. T.

“…The glycolytic activity of Paneth cells provides lactate, which is required by self-renewing intestinal stem cells for oxidative metabolism to activate p38 MAP…”
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FOXO transcription factors as mediators of stress adaptation by Rodriguez-Colman, Maria J., Dansen, Tobias B., Burgering, Boudewijn. M. T.

“…The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6) transcription factors are the mammalian orthologues of Caenorhabditis elegans…”
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Quantitative liver proteomics identifies FGF19 targets that couple metabolism and proliferation by Massafra, Vittoria, Milona, Alexandra, Vos, Harmjan R, Burgering, Boudewijn M T, van Mil, Saskia W C

“…Fibroblast growth factor 19 (FGF19) is a gut-derived peptide hormone that is produced following activation of Farnesoid X Receptor (FXR). FGF19 is secreted and…”
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Mitochondrial H2O2 release does not directly cause damage to chromosomal DNA by van Soest, Daan M. K., Polderman, Paulien E., den Toom, Wytze T. F., Keijer, Janneke P., van Roosmalen, Markus J., Leyten, Tim M. F., Lehmann, Johannes, Zwakenberg, Susan, De Henau, Sasha, van Boxtel, Ruben, Burgering, Boudewijn M. T., Dansen, Tobias B.

“…Reactive Oxygen Species (ROS) derived from mitochondrial respiration are frequently cited as a major source of chromosomal DNA mutations that contribute to…”
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Forkhead-box transcription factors and their role in the immune system by Coffer, Paul J, Burgering, Boudewijn M. T

“…It is more than a decade since the discovery of the first forkhead-box (FOX) transcription factor in the fruit fly Drosophila melanogaster. In the intervening…”
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Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy by van der Vos, Kristan E., Eliasson, Pernilla, Proikas-Cezanne, Tassula, Vervoort, Stephin J., van Boxtel, Ruben, Putker, Marrit, van Zutphen, Iris J., Mauthe, Mario, Zellmer, Sebastian, Pals, Cornelieke, Verhagen, Liesbeth P., Groot Koerkamp, Marian J. A., Braat, A. Koen, Dansen, Tobias B., Holstege, Frank C., Gebhardt, Rolf, Burgering, Boudewijn M., Coffer, Paul J.

“…The PI(3)K–PKB–FOXO signalling network provides a major intracellular hub for the regulation of cell proliferation, survival and stress resistance. Here we…”
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Stressing the role of FoxO proteins in lifespan and disease by Burgering, Boudewijn M.T, van der Horst, Armando

“…Members of the class O of forkhead box transcription factors (FoxO) have important roles in metabolism, cellular proliferation, stress tolerance and probably…”
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Functional Interaction between β-Catenin and FOXO in Oxidative Stress Signaling by Marieke A. G. Essers, Lydia M. M. de Vries-Smits, Barker, Nick, Polderman, Paulien E., Boudewijn M. T. Burgering, Korswagen, Hendrik C.

“…β-Catenin is a multifunctional protein that mediates Wnt signaling by binding to members of the T cell factor (TCF) family of transcription factors. Here, we…”
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Unravelling the tumor-suppressive functions of FOXO proteins by Dansen, Tobias B, Burgering, Boudewijn M.T

“…Members of the forkhead box O (FOXO) family of transcription factors have been postulated to be tumor suppressors because of their established roles in…”
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Farnesoid X Receptor Activation Promotes Hepatic Amino Acid Catabolism and Ammonium Clearance in Mice by Massafra, Vittoria, Milona, Alexandra, Vos, Harmjan R, Ramos, Rúben J.J, Gerrits, Johan, Willemsen, Ellen C.L, Ramos Pittol, José M, Ijssennagger, Noortje, Houweling, Martin, Prinsen, Hubertus C.M.T, Verhoeven-Duif, Nanda M, Burgering, Boudewijn M, van Mil, Saskia W.C

“…Background & Aims The nuclear receptor subfamily 1 group H member 4 (NR1H4 or farnesoid X receptor [FXR]) regulates bile acid synthesis, transport, and…”
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Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty by Burgering, Boudewijn M. T., Medema, René H.

“…Forkhead transcription factors of the FOXO family are important downstream targets of protein kinase B (PKB)/Akt, a kinase shown to play a decisive role in…”
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Berkchaetoazaphilone B has antimicrobial activity and affects energy metabolism by Ouyang, Xudong, Hoeksma, Jelmer, van der Velden, Gisela, Beenker, Wouter A. G., van Triest, Maria H., Burgering, Boudewijn M. T., den Hertog, Jeroen

“…Antimicrobial resistance has become one of the major threats to human health. Therefore, there is a strong need for novel antimicrobials with new mechanisms of…”
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Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress by Burgering, Boudewijn M. T, Kops, Geert J. P. L, Dansen, Tobias B, Polderman, Paulien E, Saarloos, Ingrid, Wirtz, Karel W. A, Coffer, Paul J, Huang, Ting-T, Bos, Johannes L, Medema, René H

“…Reactive oxygen species are required for cell proliferation but can also induce apoptosis. In proliferating cells this paradox is solved by the activation of…”
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Mdm2 induces mono-ubiquitination of FOXO4 by Brenkman, Arjan B, de Keizer, Peter L J, van den Broek, Niels J F, Jochemsen, A G, Burgering, Boudewijn M Th

“…The Forkhead box O (FOXO) class of transcription factors are involved in the regulation of several cellular responses including cell cycle progression and…”
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ALS-associated C21ORF2 variant disrupts DNA damage repair, mitochondrial metabolism, neuronal excitability and NEK1 levels in human motor neurons by Zelina, Pavol, de Ruiter, Anna Aster, Kolsteeg, Christy, van Ginneken, Ilona, Vos, Harmjan R, Supiot, Laura F, Burgering, Boudewijn M T, Meye, Frank J, Veldink, Jan H, van den Berg, Leonard H, Pasterkamp, R Jeroen

“…Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease leading to motor neuron loss. Currently mutations in > 40 genes have been…”
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FOXO Transcription Factors Both Suppress and Support Breast Cancer Progression by Hornsveld, Marten, Smits, Lydia M M, Meerlo, Maaike, van Amersfoort, Miranda, Groot Koerkamp, Marian J A, van Leenen, Dik, Kloet, David E A, Holstege, Frank C P, Derksen, Patrick W B, Burgering, Boudewijn M T, Dansen, Tobias B

“…FOXO transcription factors are regulators of cellular homeostasis and putative tumor suppressors, yet the role of FOXO in cancer progression remains to be…”
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FOXOs: signalling integrators for homeostasis maintenance by Eijkelenboom, Astrid, Burgering, Boudewijn M. T.

“…Key Points The forkhead box O (FOXO) family of transcription factors consists of four members: FOXO1, FOXO3, FOXO4 and FOXO6. At the cellular level, FOXO…”
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Genome‐wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling by Eijkelenboom, Astrid, Mokry, Michal, de Wit, Elzo, Smits, Lydia M, Polderman, Paulien E, van Triest, Miranda H, van Boxtel, Ruben, Schulze, Almut, de Laat, Wouter, Cuppen, Edwin, Burgering, Boudewijn M T

“…Forkhead box O (FOXO) transcription factors are key players in diverse cellular processes affecting tumorigenesis, stem cell maintenance and lifespan. To gain…”
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FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP by Burgering, Boudewijn M.T, van der Horst, Armando, de Vries-Smits, Alida M.M, Brenkman, Arjan B, van Triest, Miranda H, van den Broek, Niels, Colland, Frédéric, Maurice, Madelon M

“…FOXO (Forkhead box O) transcription factors are important regulators of cellular metabolism, cell-cycle progression and cell death. FOXO activity is regulated…”
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Tdrd1 acts as a molecular scaffold for Piwi proteins and piRNA targets in zebrafish by Huang, Hsin-Yi, Houwing, Saskia, Kaaij, Lucas J T, Meppelink, Amanda, Redl, Stefan, Gauci, Sharon, Vos, Harmjan, Draper, Bruce W, Moens, Cecilia B, Burgering, Boudewijn M, Ladurner, Peter, Krijgsveld, Jeroen, Berezikov, Eugene, Ketting, René F

“…Piwi proteins function in an RNAi‐like pathway that silences transposons. Piwi‐associated RNAs, also known as piRNAs, act as a guide to identify Piwi targets…”
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