Search Results - "Burger, Matthew T"

Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers by GARCIA, Pablo D, LANGOWSKI, John L, NIU, Xiao-Hong, BASHAM, Stephen, CHAN, Julie, JIANJUN YU, DOYLE, Michael, FEUCHT, Paul, WARNE, Robert, NARBERES, Jamie, TSANG, Tiffany, FRITSCH, Christine, YINGYUN WANG, KAUFFMANN, Audrey, PFISTER, Estelle, DRUECKES, Peter, TRAPPE, Joerg, WILSON, Christopher, WOOSEOK HAN, JIONG LAN, NISHIGUCHI, Gisele, LINDVALL, Mika, BELLAMACINA, Cornelia, MIN CHEN, AYCINENA, J. Alex, ZANG, Richard, HOLASH, Jocelyn, BURGER, Matthew T, CASTILLO, Joseph, FANTON, Christie, ISON, Marjorie, ZAVOROTINSKAYA, Tatiana, YUMIN DAI, JING LU

“…PIM kinases have been shown to act as oncogenes in mice, with each family member being able to drive progression of hematologic cancers. Consistent with this,…”
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Identification of N‑(4-((1R,3S,5S)‑3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies by Burger, Matthew T, Nishiguchi, Gisele, Han, Wooseok, Lan, Jiong, Simmons, Robert, Atallah, Gordana, Ding, Yu, Tamez, Victoriano, Zhang, Yanchen, Mathur, Michelle, Muller, Kristine, Bellamacina, Cornelia, Lindvall, Mika K, Zang, Richard, Huh, Kay, Feucht, Paul, Zavorotinskaya, Tatiana, Dai, Yumin, Basham, Steve, Chan, Julie, Ginn, Elaine, Aycinena, Alex, Holash, Jocelyn, Castillo, Joseph, Langowski, John L, Wang, Yingyun, Chen, Min Y, Lambert, Amy, Fritsch, Christine, Kauffmann, Audry, Pfister, Estelle, Vanasse, K. Gary, Garcia, Pablo D

“…Pan proviral insertion site of Moloney murine leukemia (PIM) 1, 2, and 3 kinase inhibitors have recently begun to be tested in humans to assess whether pan PIM…”
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Human CD180 Transmits Signals via the PIM-1L Kinase by Egli, Nicole, Zajonz, Alexandra, Burger, Matthew T, Schweighoffer, Tamas

“…Toll-like receptors (TLRs) are important sensors of the innate immune system that recognize conserved structural motifs and activate cells via a downstream…”
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Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer by Burger, Matthew T, Pecchi, Sabina, Wagman, Allan, Ni, Zhi-Jie, Knapp, Mark, Hendrickson, Thomas, Atallah, Gordana, Pfister, Keith, Zhang, Yanchen, Bartulis, Sarah, Frazier, Kelly, Ng, Simon, Smith, Aaron, Verhagen, Joelle, Haznedar, Joshua, Huh, Kay, Iwanowicz, Ed, Xin, Xiaohua, Menezes, Daniel, Merritt, Hanne, Lee, Isabelle, Wiesmann, Marion, Kaufman, Susan, Crawford, Kenneth, Chin, Michael, Bussiere, Dirksen, Shoemaker, Kevin, Zaror, Isabel, Maira, Sauveur-Michel, Voliva, Charles F

“…Phosphoinositide-3-kinases (PI3Ks) are important oncology targets due to the deregulation of this signaling pathway in a wide variety of human cancers. Herein…”
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Synthesis and in Vitro and in Vivo Evaluation of Phosphoinositide-3-kinase Inhibitors by Burger, Matthew T, Knapp, Mark, Wagman, Allan, Ni, Zhi-Jie, Hendrickson, Thomas, Atallah, Gordana, Zhang, Yanchen, Frazier, Kelly, Verhagen, Joelle, Pfister, Keith, Ng, Simon, Smith, Aaron, Bartulis, Sarah, Merrit, Hanne, Weismann, Marion, Xin, Xiaohua, Haznedar, Joshua, Voliva, Charles F, Iwanowicz, Ed, Pecchi, Sabina

“…Phospoinositide-3-kinases (PI3K) are important oncology targets due to the deregulation of this signaling pathway in a wide variety of human cancers. A series…”
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Design, Synthesis, and In Vitro and In Vivo Evaluation of Cereblon Binding Bruton’s Tyrosine Kinase (BTK) Degrader CD79b Targeted Antibody–Drug Conjugates by Zhang, Alan, Seiss, Katherine, Laborde, Laurent, Palacio-Ramirez, Sebastian, Guthy, Daniel, Lanter, Mylene, Lorber, Julien, Vulpetti, Anna, Arista, Luca, Zoller, Thomas, Radimerski, Thomas, Thoma, Claudio, Hebach, Christina, Tschantz, William R., Karpov, Alexei, Hollingworth, Gregory J., D’Alessio, Joseph A., Ferretti, Stephane, Burger, Matthew T.

“…Antibody–drug conjugates (ADCs) are an established modality that allow for targeted delivery of a potent molecule, or payload, to a desired site of action…”
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Design and Discovery of N‑(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic by Ramurthy, Savithri, Taft, Benjamin R, Aversa, Robert J, Barsanti, Paul A, Burger, Matthew T, Lou, Yan, Nishiguchi, Gisele A, Rico, Alice, Setti, Lina, Smith, Aaron, Subramanian, Sharadha, Tamez, Victoriano, Tanner, Huw, Wan, Lifeng, Hu, Cheng, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Tellew, John E, Huang, Shenlin, Yue, Qin, Chaudhary, Apurva, Tian, Hung, Iyer, Raman, Hassan, A. Quamrul, Mathews Griner, Lesley A, La Bonte, Laura R, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Mishina, Yuji, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Sellers, William R, Lees, Emma, Shao, Wenlin, Dillon, Michael P, Stuart, Darrin D

“…Direct pharmacological inhibition of RAS has remained elusive, and efforts to target CRAF have been challenging due to the complex nature of RAF signaling,…”
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Synthesis and Structure–Activity Relationship of Tetra-Substituted Cyclohexyl Diol Inhibitors of Proviral Insertion of Moloney Virus (PIM) Kinases by Han, Wooseok, Ding, Yu, Chen, Zheng, Langowski, John L, Bellamacina, Cornelia, Rico, Alice, Nishiguchi, Gisele A, Lan, Jiong, Atallah, Gordana, Lindvall, Mika, Lin, Song, Zang, Richard, Feucht, Paul, Zavorotinskaya, Tatiana, Dai, Yumin, Garcia, Pablo, Burger, Matthew T

“…Overexpression of PIM 1, 2, and 3 kinases is frequently observed in many malignancies. Previously, we discovered a potent and selective pan-PIM kinase…”
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Design and Discovery of N‑(2-Methyl-5′-morpholino-6′-((tetrahydro‑2H‑pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers by Nishiguchi, Gisele A, Rico, Alice, Tanner, Huw, Aversa, Robert J, Taft, Benjamin R, Subramanian, Sharadha, Setti, Lina, Burger, Matthew T, Wan, Lifeng, Tamez, Victoriano, Smith, Aaron, Lou, Yan, Barsanti, Paul A, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Dix, Ina, Tellew, John E, Huang, Shenlin, Mathews Griner, Lesley A, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Ma, Sylvia, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Jansen, Johanna M, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Lees, Emma, Shao, Wenlin, Stuart, Darrin D, Dillon, Michael P, Ramurthy, Savithri

“…RAS oncogenes have been implicated in >30% of human cancers, all representing high unmet medical need. The exquisite dependency on CRAF kinase in KRAS mutant…”
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Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases by Nishiguchi, Gisele A., Atallah, Gordana, Bellamacina, Cornelia, Burger, Matthew T., Ding, Yu, Feucht, Paul H., Garcia, Pablo D., Han, Wooseok, Klivansky, Liana, Lindvall, Mika

“…A series of novel 3,5-disubstituted indole derivatives as potent and selective inhibitors of all three members of the Pim kinase family is described. High…”
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Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model by Han, Wooseok, Menezes, Daniel L., Xu, Yongjin, Knapp, Mark S., Elling, Robert, Burger, Matthew T., Ni, Zhi-Jie, Smith, Aaron, Lan, Jiong, Williams, Teresa E., Verhagen, Joelle, Huh, Kay, Merritt, Hanne, Chan, John, Kaufman, Susan, Voliva, Charles F., Pecchi, Sabina

“…[Display omitted] Alterations in PI3K/AKT signaling are known to be implicated with tumorigenesis. The PI3 kinases family of lipid kinases has been an…”
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Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl carboxamide scaffold by Nishiguchi, Gisele A., Burger, Matthew T., Han, Wooseok, Lan, Jiong, Atallah, Gordana, Tamez, Victoriano, Lindvall, Mika, Bellamacina, Cornelia, Garcia, Pablo, Feucht, Paul, Zavorotinskaya, Tatiana, Dai, Yumin, Wong, Kent

“…[Display omitted] The Pim proteins (1, 2 and 3) are serine/threonine kinases that have been found to be upregulated in many hematological malignancies and…”
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Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors by Burger, Matthew T, Han, Wooseok, Lan, Jiong, Nishiguchi, Gisele, Bellamacina, Cornelia, Lindval, Mika, Atallah, Gordana, Ding, Yu, Mathur, Michelle, McBride, Chris, Beans, Elizabeth L, Muller, Kristine, Tamez, Victoriano, Zhang, Yanchen, Huh, Kay, Feucht, Paul, Zavorotinskaya, Tatiana, Dai, Yumin, Holash, Jocelyn, Castillo, Joseph, Langowski, John, Wang, Yingyun, Chen, Min Y, Garcia, Pablo D

“…Proviral insertion of Moloney virus (PIM) 1, 2, and 3 kinases are serine/threonine kinases that normally function in survival and proliferation of…”
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Synthesis and Antibacterial Activity of Novel C12 Vinyl Ketolides by Burger, Matthew T, Lin, Xiaodong, Chu, Daniel T, Hiebert, Christy, Rico, Alice C, Seid, Mehran, Carroll, Georgia L, Barker, Lynn, Huh, Kay, Langhorne, Mike, Shawar, Ribhi, Kidney, Jolene, Young, Kelly, Anderson, Scott, Desai, Manoj C, Plattner, Jacob J

“…A novel series of C12 vinyl erythromycin derivatives have been discovered which exhibit in vitro and in vivo potency against key respiratory pathogens. The C12…”
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Synthesis and antibacterial activity of novel C12 ethyl ketolides by BURGER, Matthew T, HIEBERT, Christy, SEID, Mehran, CHU, Daniel T, BARKER, Lynn, LANGHORNE, Mike, SHAWAR, Ribhi, KIDNEY, Jolene, DESAI, Manoj C, PLATTNER, Jacob J

“…A novel series of C(12) ethyl erythromycin derivatives have been discovered which exhibit in vitro and in vivo potency against key respiratory pathogens,…”
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Synthetic Ionophores. Encoded Combinatorial Libraries of Cyclen-based Receptors for Cu2+ and Co2 by Burger, Matthew T, Still, W. Clark

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Enzymatic, Polymer-Supported Formation of an Analog of the Trypsin Inhibitor A90720A:  A Screening Strategy for Macrocyclic Peptidase Inhibitors by Burger, Matthew T, Bartlett, Paul A

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Synthetic strategies in combinatorial chemistry by Spaller, Mark R, Burger, Matthew T, Fardis, Maria, Bartlett, Paul A

“…Different synthetic strategies are required for the two kinds of libraries being developed for combinatoral chemistry. Preparation of a ‘focused’ library…”
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Simple Structural Requirements for Sequence-Selective Peptide Receptors? Tripeptide Binding by a Podand Ionophore by Burger, Matthew T, Still, W. Clark

“…A simple, dye(R)-labeled and conformationally restricted ionophore 2 was prepared and screened for peptide binding using solid-supported combinatorial…”
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Free Energy Calculations in Molecular Design: Predictions by Theory and Reality by Experiment with Enantioselective Podand Ionophores by Burger, Matthew T, Armstrong, Alan, Guarnieri, Frank, McDonald, D. Quentin, Still, W. Clark

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