Search Results - "Burgan, William E."

Inhibition of Hsp90 compromises the DNA damage response to radiation by DOTE, Hideaki, BURGAN, William E, CAMPHAUSEN, Kevin, TOFILON, Philip J

“…Inhibitors of the molecular chaperone Hsp90 have been shown to enhance tumor cell radiosensitivity. To begin to address the mechanism responsible, we have…”
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In vitro and In vivo Radiosensitization of Glioblastoma Cells by the Poly (ADP-Ribose) Polymerase Inhibitor E7016 by RUSSO, Andrea L, KWON, Hyuk-Chan, CAMPHAUSEN, Kevin, BURGAN, William E, CARTER, Donna, BEAM, Katie, XU WEIZHENG, JIE ZHANG, SLUSHER, Barbara S, CHAKRAVARTI, Arnab, TOFILON, Philip J

“…Purpose: Poly (ADP-ribose) polymerase (PARP) inhibitors are undergoing clinical evaluation for cancer therapy. Because PARP inhibition has been shown to…”
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In vitro and In vivo Radiosensitization Induced by the DNA Methylating Agent Temozolomide by WHOON JONG KIL, CERNA, David, BURGAN, William E, BEAM, Katie, CARTER, Donna, STEEG, Patricia S, TOFILON, Philip J, CAMPHAUSEN, Kevin

“…Purpose: Temozolomide, a DNA methylating agent, is currently undergoing clinical evaluation for cancer therapy. Because temozolomide has been shown to increase…”
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Postradiation Sensitization of the Histone Deacetylase Inhibitor Valproic Acid by CHINNAIYAN, Prakash, COMA, David, BURGAN, William E, BEAM, Katie, WILLIAMS, Eli S, CAMPHAUSEN, Kevin, TOFILON, Philip J

“…Purpose: Preclinical studies evaluating histone deacetylase (HDAC) inhibitor-induced radiosensitization have largely focused on the preirradiation setting…”
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Enhancement of in vitro and in vivo tumor cell radiosensitivity by valproic acid by Camphausen, Kevin, Cerna, David, Scott, Tamalee, Sproull, Mary, Burgan, William E., Cerra, Michael A., Fine, Howard, Tofilon, Philip J.

“…Valproic acid (VA) is a well‐tolerated drug used to treat seizure disorders and has recently been shown to inhibit histone deacetylase (HDAC). Because HDAC…”
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In vitro and In vivo Radiosensitization with AZD6244 (ARRY-142886), an Inhibitor of Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase 1/2 Kinase by EUN JOO CHUNG, BROWN, Aaron P, ASANO, Hiroaki, MANDLER, Mariana, BURGAN, William E, CARTER, Donna, CAMPHAUSEN, Kevin, CITRIN, Deborah

“…Purpose: The mitogen-activated protein (MAP) kinase pathway is important for cell proliferation, survival, and differentiation, and is frequently up-regulated…”
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Vorinostat enhances the radiosensitivity of a breast cancer brain metastatic cell line grown in vitro and as intracranial xenografts by Baschnagel, Andrew, Russo, Andrea, Burgan, William E, Carter, Donna, Beam, Katie, Palmieri, Diane, Steeg, Patricia S, Tofilon, Philip, Camphausen, Kevin

“…Vorinostat (suberoylanilide hydroxamic acid), a histone deacetylase inhibitor, is currently undergoing clinical evaluation as therapy for cancer. We…”
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Enhancement of In vitro and In vivo Tumor Cell Radiosensitivity by the DNA Methylation Inhibitor Zebularine by DOTE, Hideaki, CERNA, David, BURGAN, William E, CARTER, Donna J, CERRA, Michael A, HOLLINGSHEAD, Melinda G, CAMPHAUSEN, Kevin, TOFILON, Philip J

“…Aberrant DNA hypermethylation is a frequent finding in tumor cells, which has suggested that inhibition of DNA methylation may be an effective cancer treatment…”
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Enhanced Tumor Cell Radiosensitivity and Abrogation of G2 and S Phase Arrest by the Hsp90 Inhibitor 17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin by BULL, Elizabeth E. A, DOTE, Hideaki, BRADY, Kristin J, BURGAN, William E, CARTER, Donna J, CERRA, Michael A, OSWALD, Kelli A, HOLLINGSHEAD, Melinda G, CAMPHAUSEN, Kevin, TOFILON, Philip J

“…Purpose: Because of the potential for affecting multiple signaling pathways, inhibition of Hsp90 may provide a strategy for enhancing tumor cell…”
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Inhibition of Akt by the alkylphospholipid perifosine does not enhance the radiosensitivity of human glioma cells by de la Peña, Lorena, Burgan, William E, Carter, Donna J, Hollingshead, Melinda G, Satyamitra, Merriline, Camphausen, Kevin, Tofilon, Philip J

“…Akt has been implicated as a molecular determinant of cellular radiosensitivity. Because it is often constitutively activated or overexpressed in malignant…”
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In vitro and In vivo Radiosensitization Induced by the Ribonucleotide Reductase Inhibitor Triapine (3-Aminopyridine-2-Carboxaldehyde-Thiosemicarbazone) by Barker, Christopher A, Burgan, William E, Carter, Donna J, Cerna, David, Gius, David, Hollingshead, Melinda G, Camphausen, Kevin, Tofilon, Philip J

“…Purpose: Because ribonucleotide reductase (RR) plays a role in DNA repair, it may serve as a molecular target for radiosensitization. Unlike previously…”
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Transcriptional signature of flavopiridol-induced tumor cell death by Lü, Xing, Burgan, William E., Cerra, Michael A., Chuang, Eric Y., Tsai, Mong-Hsun, Tofilon, Philip J., Camphausen, Kevin

“…Flavopiridol has been shown to inhibit the proliferation of a variety of human tumor cells and is currently undergoing clinical evaluation in cancer treatment…”
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A Gene Expression Signature Associated with Overall Survival in Patients with Hepatocellular Carcinoma Suggests a New Treatment Strategy by Gillet, Jean-Pierre, Andersen, Jesper B, Madigan, James P, Varma, Sudhir, Bagni, Rachel K, Powell, Katie, Burgan, William E, Wu, Chung-Pu, Calcagno, Anna Maria, Ambudkar, Suresh V, Thorgeirsson, Snorri S, Gottesman, Michael M

“…Despite improvements in the management of liver cancer, the survival rate for patients with hepatocellular carcinoma (HCC) remains dismal. The survival benefit…”
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Radiosensitization of glioma cells by modulation of Met signalling with the hepatocyte growth factor neutralizing antibody, AMG102 by Buchanan, Ian M., Scott, Tamalee, Tandle, Anita T., Burgan, William E., Burgess, Teresa L., Tofilon, Philip J., Camphausen, Kevin

“…The hepatocyte growth factor (HGF)/Met signalling pathway is up‐regulated in many cancers, with downstream mediators playing a role in DNA double strand break…”
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Molecular profiling indicates orthotopic xenograft of glioma cell lines simulate a subclass of human glioblastoma by Shankavaram, Uma T., Bredel, Markus, Burgan, William E., Carter, Donna, Tofilon, Philip, Camphausen, Kevin

“…Cell line models have been widely used to investigate glioblastoma multiforme (GBM) pathobiology and in the development of targeted therapies. However, GBM…”
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Gleevec-mediated inhibition of Rad51 expression and enhancement of tumor cell radiosensitivity by RUSSELL, Jeffery S, BRADY, Kristin, BURGAN, William E, CERRA, Michael A, OSWALD, Kelli A, CAMPHAUSEN, Kevin, TOFILON, Philip J

“…Rad51 is an essential component of the homologous DNA repair pathway and has been implicated as a determinant of cellular radiosensitivity. Gleevec is a…”
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ErbB3 expression predicts tumor cell radiosensitization induced by Hsp90 inhibition by DOTE, Hideaki, CERNA, David, BURGAN, William E, CAMPHAUSEN, Kevin, TOFILON, Philip J

“…The ability to identify tumors that are susceptible to a given molecularly targeted radiosensitizer would be of clinical benefit. Towards this end, we have…”
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Flavopiridol enhances human tumor cell radiosensitivity and prolongs expression of γH2AX foci by Camphausen, Kevin, Brady, Kristin J., Burgan, William E., Cerra, Michael A., Russell, Jeffery S., Bull, Elizabeth E.A., Tofilon, Philip J.

“…Flavopiridol is a cyclin-dependent kinase (CDK) inhibitor, which has recently entered clinical trials. However, when administered as a single agent against…”
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Development of multiplex serological assays to detect oncoviral infections by Burgan, William E, Beam, Katie, Bess, Matthew, Meade, Allison, Wakeham, Katie, Newton, Robert, Whitby, Denise, Bagni, Rachel K

“…Doc number: P30…”
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Abstract A028: An isogenic H/N/KRAS-less mouse embryonic fibroblast cell line panel derived from a size sorted diploid clonal parent by Burgan, William E., Fer, Nicole, Powell, Katie, Xu, Bingfang, Meyer, Mackenzie, Eury, Scott, Neish, Abigail, Soppet, Daniel, Esposito, Dominic, McCormick, Frank, Nissley, Dwight V.

“…Abstract Shortly after the formation of the NCI Ras Initiative, a H/N/KRAS-less mouse embryonic fibroblast (MEF) cell line panel was generated, validated, and…”
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