Search Results - "Burga, Laura N"

PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells by Israelsen, William J., Dayton, Talya L., Davidson, Shawn M., Fiske, Brian P., Hosios, Aaron M., Bellinger, Gary, Li, Jie, Yu, Yimin, Sasaki, Mika, Horner, James W., Burga, Laura N., Xie, Jianxin, Jurczak, Michael J., DePinho, Ronald A., Clish, Clary B., Jacks, Tyler, Kibbey, Richard G., Wulf, Gerburg M., Di Vizio, Dolores, Mills, Gordon B., Cantley, Lewis C., Vander Heiden, Matthew G.

“…The pyruvate kinase M2 isoform (PKM2) is expressed in cancer and plays a role in regulating anabolic metabolism. To determine whether PKM2 is required for…”
Get full text

Structural basis for anthrax toxin receptor 1 recognition by Seneca Valley Virus by Jayawardena, Nadishka, Burga, Laura N., Easingwood, Richard A., Takizawa, Yoshimasa, Wolf, Matthias, Bostina, Mihnea

“…Recently, the use of oncolytic viruses in cancer therapy has become a realistic therapeutic option. Seneca Valley Virus (SVV) is a newly discovered…”
Get full text

Variation in structural motifs within SARS-related coronavirus spike proteins by Hills, Francesca R, Eruera, Alice-Roza, Hodgkinson-Bean, James, Jorge, Fátima, Easingwood, Richard, Brown, Simon H J, Bouwer, James C, Li, Yi-Ping, Burga, Laura N, Bostina, Mihnea

“…SARS-CoV-2 is the third known coronavirus (CoV) that has crossed the animal-human barrier in the last two decades. However, little structural information…”
Get full text

Visualizing Nudivirus Assembly and Egress by Velamoor, Sailakshmi, Mitchell, Allan, Humbel, Bruno M., Kim, WonMo, Pushparajan, Charlotte, Visnovsky, Gabriel, Burga, Laura N., Bostina, Mihnea

“…The dynamics of nuclear envelope has a critical role in multiple cellular processes. However, little is known regarding the structural changes occurring inside…”
Get full text

N-Linked Glycosylation on Anthrax Toxin Receptor 1 Is Essential for Seneca Valley Virus Infection by Jayawardena, Nadishka, Miles, Linde A, Burga, Laura N, Rudin, Charles, Wolf, Matthias, Poirier, John T, Bostina, Mihnea

“…Seneca Valley virus (SVV) is a picornavirus with potency in selectively infecting and lysing cancerous cells. The cellular receptor for SVV mediating the…”
Get full text

Prolyl isomerase Pin1 is highly expressed in Her2-positive breast cancer and regulates erbB2 protein stability by Lam, Prudence B, Burga, Laura N, Wu, Bryan P, Hofstatter, Erin W, Lu, Kun Ping, Wulf, Gerburg M

“…Overexpression of HER-2/Neu occurs in about 25-30% of breast cancer patients and is indicative of poor prognosis. While Her2/Neu overexpression is primarily a…”
Get full text

Altered Proliferation and Differentiation Properties of Primary Mammary Epithelial Cells from BRCA1 Mutation Carriers by BURGA, Laura N, TUNG, Nadine M, WULF, Gerburg M, TROYAN, Susan L, BOSTINA, Mihnea, KONSTANTINOPOULOS, Panagiotis A, FOUNTZILAS, Helena, SPENTZOS, Dimitrios, MIRON, Alexander, YASSIN, Yosuf A, LEE, Bernard T

“…Female BRCA1 mutation carriers have a nearly 80% probability of developing breast cancer during their life-time. We hypothesized that the breast epithelium at…”
Get full text

Cryo-Electron Microscopy Structure of Seneca Valley Virus Procapsid by Strauss, Mike, Jayawardena, Nadishka, Sun, Eileen, Easingwood, Richard A, Burga, Laura N, Bostina, Mihnea

“…Seneca Valley virus (SVV), like some other members of the , forms naturally occurring empty capsids, known as procapsids. Procapsids have the same antigenicity…”
Get full text

Characterisation of a Seneca Valley virus thermostable mutant by Jayawardena, Nadishka, McCarthy, Cormac, Wang, Ivy, Waqqar, Shakeel, Burga, Laura N., Strauss, Mike, Bostina, Mihnea

“…Seneca Valley virus (SVV) is a newly discovered picornavirus in the Senecavirus genus. SVV-001 strain has shown promise as an oncolytic virus against tumors…”
Get full text

Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer by Juvekar, Ashish, Burga, Laura N, Hu, Hai, Lunsford, Elaine P, Ibrahim, Yasir H, Balmañà, Judith, Rajendran, Anbazhagan, Papa, Antonella, Spencer, Katherine, Lyssiotis, Costas A, Nardella, Caterina, Pandolfi, Pier Paolo, Baselga, José, Scully, Ralph, Asara, John M, Cantley, Lewis C, Wulf, Gerburg M

“…There is a need to improve treatments for metastatic breast cancer. Here, we show the activation of the phosphoinositide 3-kinase (PI3K) and mitogen-activated…”
Get more information

Developing Picornaviruses for Cancer Therapy by McCarthy, Cormac, Jayawardena, Nadishka, Burga, Laura N, Bostina, Mihnea

“…Oncolytic viruses (OVs) form a group of novel anticancer therapeutic agents which selectively infect and lyse cancer cells. Members of several viral families,…”
Get full text

Anthrax toxin receptor 1 is the cellular receptor for Seneca Valley virus by Miles, Linde A, Burga, Laura N, Gardner, Eric E, Bostina, Mihnea, Poirier, John T, Rudin, Charles M

“…Seneca Valley virus (SVV) is an oncolytic picornavirus with selective tropism for neuroendocrine cancers. It has shown promise as a cancer therapeutic in…”
Get full text

Beyond the surface: Investigation of tumorsphere morphology using volume electron microscopy by Jadav, Nickhil, Velamoor, Sailakshmi, Huang, Daniel, Cassin, Léna, Hazelton, Niki, Eruera, Alice-Roza, Burga, Laura N, Bostina, Mihnea

“…The advent of volume electron microscopy (vEM) has provided unprecedented insights into cellular and subcellular organization, revolutionizing our…”
Get full text

Virus-Receptor Interactions and Virus Neutralization: Insights for Oncolytic Virus Development by Jayawardena, Nadishka, Poirier, John T, Burga, Laura N, Bostina, Mihnea

“…Oncolytic viruses (OVs) are replication competent agents that selectively target cancer cells. After penetrating the tumor cell, viruses replicate and…”
Get full text

Virus–Receptor Interactions: Structural Insights For Oncolytic Virus Development by Jayawardena, Nadishka, Burga, Laura N, Poirier, John T, Bostina, Mihnea

“…Recent advancements in oncolytic virotherapy commend a special attention to developing new strategies for targeting cancer cells with oncolytic viruses (OVs)…”
Get full text

Directed Evolution of Seneca Valley Virus in Tumorsphere and Monolayer Cell Cultures of a Small-Cell Lung Cancer Model by Waqqar, Shakeel, Lee, Kai, Lawley, Blair, Bilton, Timothy, Quiñones-Mateu, Miguel E, Bostina, Mihnea, Burga, Laura N

“…The Seneca Valley virus (SVV) is an oncolytic virus from the picornavirus family, characterized by a 7.3-kilobase RNA genome encoding for all the structural…”
Get full text

Correction: McCarthy, C.; et al . Developing Picornaviruses for Cancer Therapy. Cancers 2019, 11 , 685 by McCarthy, Cormac, Jayawardena, Nadishka, Burga, Laura N, Bostina, Mihnea

“…The authors wish to make the following corrections to this paper [1] [...]…”
Get full text

Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition prevents estrogen receptor-negative cancers in BRCA1-mutant mice by Burga, Laura N, Hu, Hai, Juvekar, Ashish, Tung, Nadine M, Troyan, Susan L, Hofstatter, Erin W, Wulf, Gerburg M

“…Women who carry a BRCA1 mutation typically develop "triple-negative" breast cancers (TNBC), defined by the absence of estrogen receptor (ER), progesterone…”
Get full text