Search Results - "Burg, Thomas P"

Nanoparticle Characterization: What to Measure? by Modena, Mario M., Rühle, Bastian, Burg, Thomas P., Wuttke, Stefan

“…What to measure? is a key question in nanoscience, and it is not straightforward to address as different physicochemical properties define a nanoparticle…”
Get full text

Weighing of biomolecules, single cells and single nanoparticles in fluid by Carlson, Greg, Burg, Thomas P, Godin, Michel, Foster, John S, Knudsen, Scott M, Shen, Wenjiang, Manalis, Scott R, Babcock, Ken

“…Nanomechanical resonators enable the measurement of mass with extraordinary sensitivity. Previously, samples as light as 7 zeptograms (1 zg  =  10-21 g) have…”
Get full text

Model-Based Optimization of Solid-Supported Micro-Hotplates for Microfluidic Cryofixation by Thiem, Daniel B, Szabo, Greta, Burg, Thomas P

“…Cryofixation by ultra-rapid freezing is widely regarded as the gold standard for preserving cell structure without artefacts for electron microscopy. However,…”
Get full text

Nanoparticle Characterization: Nanoparticle Characterization: What to Measure? (Adv. Mater. 32/2019) by Modena, Mario M., Rühle, Bastian, Burg, Thomas P., Wuttke, Stefan

“…Despite the large variety of measurement techniques, determining the key physicochemical properties of nanoparticles remains a critical challenge for…”
Get full text

Robust Smartphone Assisted Biosensing Based on Asymmetric Nanofluidic Grating Interferometry by Purr, Foelke, Eckardt, Max-Frederik, Kieserling, Jonas, Gronwald, Paul-Luis, Burg, Thomas P, Dietzel, Andreas

“…Point-of-care systems enable fast therapy decisions on site without the need of any healthcare infrastructure. In addition to the sensitive detection, stable…”
Get full text

A Microfluidic Split-Flow Technology for Product Characterization in Continuous Low-Volume Nanoparticle Synthesis by Bolze, Holger, Erfle, Peer, Riewe, Juliane, Bunjes, Heike, Dietzel, Andreas, Burg, Thomas P

“…A key aspect of microfluidic processes is their ability to perform chemical reactions in small volumes under continuous flow. However, a continuous process…”
Get full text

Nanofluidic Immobilization and Growth Detection of Escherichia coli in a Chip for Antibiotic Susceptibility Testing by Busche, Jan F, Möller, Svenja, Klein, Ann-Kathrin, Stehr, Matthias, Purr, Foelke, Bassu, Margherita, Burg, Thomas P, Dietzel, Andreas

“…Infections with antimicrobial resistant bacteria are a rising threat for global healthcare as more and more antibiotics lose their effectiveness against…”
Get full text

Time Resolved Cryo‐Correlative Light and Electron Microscopy by Szabo, Gréta V., Burg, Thomas P.

“…Complex materials exhibit fascinating features especially in situations far from equilibrium. Thus, methods for investigating structural dynamics with…”
Get full text

Mass Measurements Reveal Preferential Sorption of Mixed Solvent Components in Porous Nanoparticles by Modena, Mario M., Hirschle, Patrick, Wuttke, Stefan, Burg, Thomas P.

“…The interplay of physical and chemical properties at the nanometer scale provides porous nanoparticles with unique sorption and interaction capabilities. These…”
Get full text

Continuous Production of Lipid Nanoparticles by Ultrasound‐Assisted Microfluidic Antisolvent Precipitation by Bolze, Holger, Riewe, Juliane, Bunjes, Heike, Dietzel, Andreas, Burg, Thomas P.

“…Microfluidic processes are of interest for the production of pharmaceutical nanoparticles due to the uniform characteristics attainable by such devices…”
Get full text

Toward Attogram Mass Measurements in Solution with Suspended Nanochannel Resonators by Lee, Jungchul, Shen, Wenjiang, Payer, Kris, Burg, Thomas P, Manalis, Scott R

“…Using suspended nanochannel resonators (SNRs), we demonstrate measurements of mass in solution with a resolution of 27 ag in a 1 kHz bandwidth, which…”
Get full text

Protective Filtration for Microfluidic Nanoparticle Precipitation for Pharmaceutical Applications by Bolze, Holger, Riewe, Juliane, Bunjes, Heike, Dietzel, Andreas, Burg, Thomas P.

“…Microfluidic processes are of great interest for the production of nanoparticles with reproducible properties. However, in real systems, it is difficult to…”
Get full text

Fabrication and Characterization of an Integrated Microsystem for Protein Preconcentration and Sensing by Dextras, P, Payer, K R, Burg, T P, Wenjiang Shen, Ying-Chih Wang, Jongyoon Han, Manalis, S R

“…We report on a fabrication and packaging process for a microsystem consisting of a mass-based protein detector and a fully integrated preconcentrator…”
Get full text

Aberration-corrected cryoimmersion light microscopy by Faoro, Raffaele, Bassu, Margherita, Mejia, Yara X., Stephan, Till, Dudani, Nikunj, Boeker, Christian, Jakobs, Stefan, Burg, Thomas P.

“…Cryogenic fluorescent light microscopy of flash-frozen cells stands out by artifact-free fixation and very little photobleaching of the fluorophores used. To…”
Get full text

Resolution enhancement of suspended microchannel resonators for weighing of biomolecular complexes in solution by Modena, Mario M, Wang, Yu, Riedel, Dietmar, Burg, Thomas P

“…We introduce the use of correlation analysis to extend the dynamic range of suspended micro- and nanochannel resonator (SMR/SNR) mass sensors by over five…”
Get more information

In situ Microfluidic Cryofixation for Cryo Focused Ion Beam Milling and Cryo Electron Tomography by Fuest, Marie, Schaffer, Miroslava, Nocera, Giovanni Marco, Galilea-Kleinsteuber, Rodrigo I., Messling, Jan-Erik, Heymann, Michael, Plitzko, Jürgen M., Burg, Thomas P.

“…We present a microfluidic platform for studying structure-function relationships at the cellular level by connecting video rate live cell imaging with in situ…”
Get full text

Measuring the mass, density, and size of particles and cells using a suspended microchannel resonator by Godin, Michel, Bryan, Andrea K., Burg, Thomas P., Babcock, Ken, Manalis, Scott R.

“…We demonstrate the measurement of mass, density, and size of cells and nanoparticles using suspended microchannel resonators. The masses of individual…”
Get full text

The Importance of Dean Flow in Microfluidic Nanoparticle Synthesis: A ZIF‐8 Case Study by Yu, Xiangjiang, Andreo, Jacopo, Walden, Madeline, Campo, Javier F., Basabe‐Desmonts, Lourdes, Benito‐Lopez, Fernando, Burg, Thomas P., Wuttke, Stefan

“…The Dean Flow, a physics phenomenon that accounts for the impact of channel curvature on fluid dynamics, has great potential to be used in microfluidic…”
Get full text

Nonmonotonic energy dissipation in microfluidic resonators by Burg, Thomas P, Sader, John E, Manalis, Scott R

“…Nanomechanical resonators enable a range of precision measurements in air or vacuum, but strong viscous damping makes applications in liquid challenging…”
Get full text

Microfluidic cryofixation for correlative microscopy by Mejia, Yara X, Feindt, Holger, Zhang, Dongfeng, Steltenkamp, Siegfried, Burg, Thomas P

“…Cryofixation yields outstanding ultrastructural preservation of cells for electron microscopy, but current methods disrupt live cell imaging. Here we…”
Get more information