Search Results - "Burg, M B"

Molecular basis of osmotic regulation by Burg, M B

“…Cells almost universally respond to the stress of long-term hyperosmolality by accumulating compatible organic osmolytes. This allows them to maintain normal…”
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Cell cycle delay and apoptosis are induced by high salt and urea in renal medullary cells by Michea, L, Ferguson, D R, Peters, E M, Andrews, P M, Kirby, M R, Burg, M B

“…We investigated the effects of hyperosmolality on survival and proliferation of subconfluent cultures of mIMCD3 mouse renal collecting duct cells. High NaCl…”
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Renal medullary organic osmolytes by Garcia-Perez, A, Burg, M B

“…Sorbitol, inositol, GPC, and betaine are the predominant organic osmolytes in renal medullary cells. They protect the cells from harmful effects of the high…”
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Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade by HURWITZ, A. A, FOSTER, B. A, KWON, E. D, TRUONG, T, CHOI, E. M, GREENBERG, N. M, BURG, M. B, ALLISON, J. P

“…We have previously shown that antibodies to CTLA-4, an inhibitory receptor on T cells, can be effective at inducing regression of transplantable murine tumors…”
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Macromolecular crowding and confinement in cells exposed to hypertonicity by Garner, M M, Burg, M B

“…The nonideal properties of solutions containing high concentrations of macromolecules can result in enormous increases in the activity of the individual…”
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Cloning of the cDNa for a Na+/myo-inositol cotransporter, a hypertonicity stress protein by MOO KWON, H, YAMAUCHI, A, UCHIDA, S, PRESTON, A. S, GARCIA-PEREZ, A, BURG, M. B, HANDLER, J. S

“…Kidney medullary cells in situ, as well as kidney-derived Madin-Darby canine kidney (MDCK) cells accumulate nonperturbing, small organic solutes (osmolytes),…”
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Cloning of a Na(+)- and Cl(-)-dependent betaine transporter that is regulated by hypertonicity by Yamauchi, A, Uchida, S, Kwon, H M, Preston, A S, Robey, R B, Garcia-Perez, A, Burg, M B, Handler, J S

“…Many hypertonic bacteria, plants, marine animals, and the mammalian renal medulla are protected from the deleterious effects of high intracellular…”
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Induction of gene expression by heat shock versus osmotic stress by Sheikh-Hamad, D, García-Pérez, A, Ferraris, J D, Peters, E M, Burg, M B

“…Elevated temperature rapidly increases expression of genes for heat shock proteins (HSP), including HSP-70. The response is presumably triggered by…”
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Kidney aldose reductase gene transcription is osmotically regulated by Smardo, Jr, F L, Burg, M B, Garcia-Perez, A

“…Cells generally adapt to long-term hypertonic stress by accumulating organic osmolytes. PAP-HT25 renal medullary cells in hypertonic medium accumulate sorbitol…”
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Accumulation of Glycerophosphocholine (GPC) by Renal Cells: Osmotic Regulation of GPC: Choline Phosphodiesterase by ZABLOCKI, K, MILLER, S. P. F, GARCIA-PEREZ, A, BURG, M. B

“…Although GPC has long been recognized as a degradation product of phosphatidylcholine, only recently is there wide appreciation of its role as a compatible and…”
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Counteracting effects of urea and betaine in mammalian cells in culture by Yancey, P H, Burg, M B

“…Urea and methylamines, such as betaine, are among the major organic osmotic effectors accumulated by organisms under hyperosmotic (high NaCl) stress; the…”
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Distribution of major organic osmolytes in rabbit kidneys in diuresis and antidiuresis by Yancey, P H, Burg, M B

“…Sorbitol, glycerophosphorylcholine (GPC), inositol, and betaine are organic osmolytes that accumulate in renal medullary cells. Two roles have been proposed…”
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Osmoregulation of betaine transport in mammalian renal medullary cells by Nakanishi, T, Turner, R J, Burg, M B

“…Escherichia coli and Staphylococcus typhimurium are known to accumulate betaine by increased transport when extracellular osmolality rises. In the present…”
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Coordinate regulation of organic osmolytes in renal cells by Burg, Mourice B.

“…Coordinate regulation of organic osmolytes in renal cells. Adaptation of cells to prolonged hypertonicity generally involves accumulation of compatible organic…”
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Sorbitol, osmoregulation, and the complications of diabetes by BURG, M. B, KADOR, P. F

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Osmoregulatory Changes in myo-Inositol Transport by Renal Cells by Nakanishi, Takeshi, Turner, R. James, Burg, Maurice B.

“…Renal medullary cells contain high concentrations of myo-inositol, sorbitol, betaine, and glycerophosphocholine, whose levels vary with urinary osmolality…”
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Survey of osmolytes in renal cell lines by Nakanishi, T, Balaban, R S, Burg, M B

“…In renal medullas during antidiuresis, the extracellular fluid is hyperosmotic because of high concentrations of NaCl and urea. Under those conditions, the…”
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Induction of Aldose Reductase and Sorbitol in Renal Inner Medullary Cells by Elevated Extracellular NaCl by Bagnasco, Serena M., Uchida, Shunya, Balaban, Robert S., Kador, Peter F., Burg, Maurice B.

“…Aldose reductase [aldehyde reductase 2; alditol:NAD(P)+1-oxidoreductase, EC 1.1.1.21] catalyzes conversion of glucose to sorbitol. Although its activity is…”
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Molecular cloning of cDNA coding for kidney aldose reductase. Regulation of specific mRNA accumulation by NaCl-mediated osmotic stress by A Garcia-Perez, B Martin, H R Murphy, S Uchida, H Murer, B D Cowley, Jr, J S Handler, M B Burg

“…Cells generally respond to long-term hyperosmotic stress by accumulating nonperturbing organic osmolytes. Unlike bacteria, in which molecular mechanisms…”
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Osmotic regulation of aldose reductase protein synthesis in renal medullary cells by Moriyama, T, Garcia-Perez, A, Burg, M B

“…Renal medullary cells are normally exposed to high extracellular NaCl as part of the urinary concentrating mechanism. They react to this stress by accumulating…”
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