Search Results - "Burg, Jonathan M"
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Characterization of the plant homeodomain (PHD) reader family for their histone tail interactions
Published in Epigenetics & chromatin (24-01-2020)“…Plant homeodomain (PHD) fingers are central "readers" of histone post-translational modifications (PTMs) with > 100 PHD finger-containing proteins encoded by…”
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KDM1 class flavin-dependent protein lysine demethylases
Published in Biopolymers (01-07-2015)“…ABSTRACT Flavin‐dependent, lysine‐specific protein demethylases (KDM1s) are a subfamily of amine oxidases that catalyze the selective posttranslational…”
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Lysine-Specific Demethylase 1A (KDM1A/LSD1): Product Recognition and Kinetic Analysis of Full-Length Histones
Published in Biochemistry (Easton) (22-03-2016)“…Lysine-specific demethylase 1A (KDM1A/LSD1) is a FAD-dependent enzyme that catalyzes the oxidative demethylation of histone H3K4me1/2 and H3K9me1/2 repressing…”
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A rationally-designed chimeric KDM1A/KDM1B histone demethylase tower domain deletion mutant retaining enzymatic activity
Published in FEBS letters (19-08-2015)“…•A KDM1A/KDM1B chimera was engineered to omit the protein-interacting tower domain.•The enzymatically active chimera copurifies with a stoichiometric…”
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Decoding the protein composition of whole nucleosomes with Nuc-MS
Published in Nature methods (01-03-2021)“…Current proteomic approaches disassemble and digest nucleosome particles, blurring readouts of the ‘histone code’. To preserve nucleosome-level information, we…”
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A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer
Published in Genes & development (01-12-2021)“…Mutations in the chromatin regulator cause the human neurodevelopmental disorder Chung-Jansen syndrome, while alterations in expression are linked to cancer…”
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Quantification of citrullinated histones: Development of an improved assay to reliably quantify nucleosomal H3Cit in human plasma
Published in Journal of thrombosis and haemostasis (01-10-2020)“…Background Recent data propose a diagnostic and prognostic capacity for citrullinated histone H3 (H3Cit), a marker of neutrophil extracellular traps (NETs), in…”
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Large-scale bioprocess competitiveness: the potential of dynamic metabolic control in two-stage fermentations
Published in Current opinion in chemical engineering (01-11-2016)“…[Display omitted] •Comparison of biocatalysts/bioprocesses with traditional chemical catalysts/processes.•Turnover rates of biocatalysts can exceed those of…”
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Insights into the Autoproteolytic Processing and Catalytic Mechanism of the Chlamydia trachomatis Virulence-Associated Protease CPAF
Published in Biochemistry (Easton) (20-08-2019)“…CPAF (chlamydial protease-like activity factor) is a Chlamydia trachomatis protease that is translocated into the host cytosol during infection. CPAF activity…”
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An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability
Published in eLife (19-05-2023)“…In nucleosomes, histone N-terminal tails exist in dynamic equilibrium between free/accessible and collapsed/DNA-bound states. The latter state is expected to…”
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Nucleosome conformation dictates the histone code
Published in eLife (06-02-2024)“…Histone post-translational modifications (PTMs) play a critical role in chromatin regulation. It has been proposed that these PTMs form localized 'codes' that…”
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Structural basis of histone H2A lysine 119 deubiquitination by Polycomb repressive deubiquitinase BAP1/ASXL1
Published in Science advances (09-08-2023)“…Histone H2A lysine 119 (H2AK119Ub) is monoubiquitinated by Polycomb repressive complex 1 and deubiquitinated by Polycomb repressive deubiquitinase complex…”
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Specificity and Affinity of BPTF PHD Finger and Bromodomain in the Context of the Nucleosome
Published in Biophysical journal (07-02-2020)Get full text
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Abstract 7027: Direct multi-omics for the masses: Linking DNA methylation to chromatin targets via TEM-seq
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Abstract DNA methylation (DNAme) is an epigenetic mark that includes the modification of cytosine resides (5mC) within CpG islands. In addition to well…”
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Abstract 7026: Multi-omic genomic mapping with long read sequencing
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Abstract Gene transcription is regulated by the complex interplay between histone post-translational modifications (PTMs), chromatin associated proteins…”
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Abstract 4728: Biochemical and genomic approaches for high throughput drug discovery in chromatin remodeling research
Published in Cancer research (Chicago, Ill.) (04-04-2023)“…Abstract Chromatin remodeling is mediated by ATP-dependent enzymes that play key roles regulating gene expression and genome replication/repair. Aberrant…”
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Abstract B015: Versatile biochemical and genomic platforms for drug discovery in chromatin remodeling research
Published in Cancer research (Chicago, Ill.) (01-12-2022)“…Abstract Chromatin remodeling, driven by ATP-dependent remodeling enzymes, plays key roles in regulating gene expression, genome replication and repair…”
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The relationship between the quality of the coach-athlete relationship and perceptions of the motivational climate
Published 01-01-2008“…Sport psychology researchers have developed an approach to leadership involving the investigation of interpersonal relationships between coaches and athletes…”
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Dissertation