Search Results - "Burden, David A"

Inhibition of the Interleukin-36 Pathway for the Treatment of Generalized Pustular Psoriasis by Bachelez, Hervé, Choon, Siew-Eng, Marrakchi, Slaheddine, Burden, A. David, Tsai, Tsen-Fang, Morita, Akimichi, Turki, Hamida, Hall, David B, Shear, Michael, Baum, Patrick, Padula, Steven J, Thoma, Christian

“…Seven patients with pustular psoriasis, three with mutations in IL36RN , were treated with a monoclonal antibody against interleukin-36 receptor and had…”
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Differential Drug Survival of Biologic Therapies for the Treatment of Psoriasis: A Prospective Observational Cohort Study from the British Association of Dermatologists Biologic Interventions Register (BADBIR) by Warren, Richard B., Smith, Catherine H., Yiu, Zenas Z.N., Ashcroft, Darren M., Barker, Jonathan N.W.N., Burden, A. David, Lunt, Mark, McElhone, Kathleen, Ormerod, Anthony D., Owen, Caroline M., Reynolds, Nick J., Griffiths, Christopher E.M.

“…Drug survival reflects a drug’s effectiveness, safety, and tolerability. We assessed the drug survival of biologics used to treat psoriasis in a prospective…”
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Response to: Letter to Editor Regarding “Spesolimab Efficacy and Safety in Patients with Moderate-to-Severe Palmoplantar Pustulosis: A Multicentre, Double-Blind, Randomised, Placebo-Controlled, Phase IIb, Dose-Finding Study” by Burden, A. David

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Comparison of Drug Discontinuation, Effectiveness, and Safety Between Clinical Trial Eligible and Ineligible Patients in BADBIR by Mason, Kayleigh J, Barker, Jonathan N W N, Smith, Catherine H, Hampton, Philip J, Lunt, Mark, McElhone, Kathleen, Warren, Richard B, Yiu, Zenas Z N, Griffiths, Christopher E M, Burden, A David

“…Patients with psoriasis enrolled in clinical trials of biologics may not be representative of the real-world population. There is evidence that patients…”
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Mutations in IL36RN/IL1F5 Are Associated with the Severe Episodic Inflammatory Skin Disease Known as Generalized Pustular Psoriasis by Onoufriadis, Alexandros, Simpson, Michael A., Pink, Andrew E., Di Meglio, Paola, Smith, Catherine H., Pullabhatla, Venu, Knight, Jo, Spain, Sarah L., Nestle, Frank O., Burden, A. David, Capon, Francesca, Trembath, Richard C., Barker, Jonathan N.

“…Generalized pustular psoriasis (GPP) is a rare and yet potentially lethal clinical variant of psoriasis, characterized by the formation of sterile cutaneous…”
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Psoriasis and Other Complex Trait Dermatoses: From Loci to Functional Pathways by Capon, Francesca, Burden, A David, Trembath, Richard C., Barker, Jonathan N.

“…Driven by advances in molecular genetic technologies and statistical analysis methodologies, there have been huge strides taken in dissecting the complex…”
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Single-cell analysis implicates TH17-to-TH2 cell plasticity in the pathogenesis of palmoplantar pustulosis by McCluskey, Daniel, Benzian-Olsson, Natashia, Mahil, Satveer K., Hassi, Niina Karoliina, Wohnhaas, Christian T., Burden, A. David, Griffiths, Christopher E.M., Ingram, John R., Levell, Nick J., Parslew, Richard, Pink, Andrew E., Reynolds, Nick J., Warren, Richard B., Visvanathan, Sudha, Baum, Patrick, Barker, Jonathan N., Smith, Catherine H., Capon, Francesca

“…Palmoplantar pustulosis (PPP) is a severe inflammatory skin disorder characterized by eruptions of painful, neutrophil-filled pustules on the palms and soles…”
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Study protocol of the global Effisayil 1 Phase II, multicentre, randomised, double-blind, placebo-controlled trial of spesolimab in patients with generalized pustular psoriasis presenting with an acute flare by Choon, Siew Eng, Lebwohl, Mark G, Marrakchi, Slaheddine, Burden, A David, Tsai, Tsen-Fang, Morita, Akimichi, Navarini, Alexander A, Zheng, Min, Xu, Jinhua, Turki, Hamida, Rajeswari, Sushmita, Deng, Hongjie, Tetzlaff, Kay, Thoma, Christian, Bachelez, Hervé

“…IntroductionGeneralized pustular psoriasis (GPP) is a rare, potentially life-threatening disease characterised by recurrent flares of widespread neutrophilic…”
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AP1S3 Mutations Are Associated with Pustular Psoriasis and Impaired Toll-like Receptor 3 Trafficking by Setta-Kaffetzi, Niovi, Simpson, Michael A., Navarini, Alexander A., Patel, Varsha M., Lu, Hui-Chun, Allen, Michael H., Duckworth, Michael, Bachelez, Hervé, Burden, A. David, Choon, Siew-Eng, Griffiths, Christopher E.M., Kirby, Brian, Kolios, Antonios, Seyger, Marieke M.B., Prins, Christa, Smahi, Asma, Trembath, Richard C., Fraternali, Franca, Smith, Catherine H., Barker, Jonathan N., Capon, Francesca

“…Adaptor protein complex 1 (AP-1) is an evolutionary conserved heterotetramer that promotes vesicular trafficking between the trans-Golgi network and the…”
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Activating CARD14 Mutations Are Associated with Generalized Pustular Psoriasis but Rarely Account for Familial Recurrence in Psoriasis Vulgaris by Berki, Dorottya M., Liu, Lu, Choon, Siew-Eng, David Burden, A., Griffiths, Christopher E.M., Navarini, Alexander A., Tan, Eugene S., Irvine, Alan D., Ranki, Annamari, Ogo, Takeshi, Petrof, Gabriela, Mahil, Satveer K., Duckworth, Michael, Allen, Michael H., Vito, Pasquale, Trembath, Richard C., McGrath, John, Smith, Catherine H., Capon, Francesca, Barker, Jonathan N.

“…Caspase recruitment family member 14 (CARD14, also known as CARMA2), is a scaffold protein that mediates NF-κB signal transduction in skin keratinocytes…”
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Rare Pathogenic Variants in IL36RN Underlie a Spectrum of Psoriasis-Associated Pustular Phenotypes by Setta-Kaffetzi, Niovi, Navarini, Alexander A., Patel, Varsha M., Pullabhatla, Venu, Pink, Andrew E., Choon, Siew-Eng, Allen, Michael A., Burden, A David, Griffiths, Christopher E.M., Seyger, Marieke M.B., Kirby, Brian, Trembath, Richard C., Simpson, Michael A., Smith, Catherine H., Capon, Francesca, Barker, Jonathan N.

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British Association of Dermatologists guidelines for biologic therapy for psoriasis 2023: a pragmatic update by Smith, Catherine H, Yiu, Zenas Z N, Bale, Tracy, Burden, A David, Coates, Laura C, Eckert, Elizabeth, Longley, Nicky, Mahil, Satveer K, McGuire, Arlene, Murphy, Ruth, Nelson-Piercy, Catherine, Owen, Caroline M, Parslew, Richard, Woolf, Richard T, Mansour Kiaee, Zahra, Constantin, Alina M, Ezejimofor, Martinsixtus C, Exton, Lesley S, Mohd Mustapa, M Firouz

“…The article provides a pragmatic update of the British Association of Dermatologists guidelines for biologic therapy for psoriasis…”
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Association of Clinical and Demographic Factors With the Severity of Palmoplantar Pustulosis by Benzian-Olsson, Natashia, Dand, Nick, Chaloner, Charlotte, Bata-Csorgo, Zsuzsa, Borroni, Riccardo, Burden, A David, Cooper, Hywel L, Cornelius, Victoria, Cro, Suzie, Dasandi, Tejus, Griffiths, Christopher E M, Kingo, Külli, Koks, Sulev, Lachmann, Helen, McAteer, Helen, Meynell, Freya, Mrowietz, Ulrich, Parslew, Richard, Patel, Prakash, Pink, Andrew E, Reynolds, Nick J, Tanew, Adrian, Torz, Kaspar, Trattner, Hannes, Wahie, Shyamal, Warren, Richard B, Wright, Andrew, Barker, Jonathan N, Navarini, Alexander A, Smith, Catherine H, Capon, Francesca

“…Although palmoplantar pustulosis (PPP) can significantly impact quality of life, the factors underlying disease severity have not been studied. To examine the…”
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Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene by Capon, Francesca, Bijlmakers, Marie-José, Wolf, Natalie, Quaranta, Maria, Huffmeier, Ulrike, Allen, Michael, Timms, Kirsten, Abkevich, Victor, Gutin, Alexander, Smith, Rhodri, Warren, Richard B., Young, Helen S., Worthington, Jane, Burden, A. David, Griffiths, Christopher E.M., Hayday, Adrian, Nestle, Frank O., Reis, Andre, Lanchbury, Jerry, Barker, Jonathan N., Trembath, Richard C.

“…Psoriasis is an immune-mediated skin disorder that is inherited as a multifactorial trait. Linkage studies have clearly identified a primary disease…”
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Dysregulation of Connexin Expression Plays a Pivotal Role in Psoriasis by O’Shaughnessy, Erin M., Duffy, William, Garcia-Vega, Laura, Hussey, Keith, Burden, A. David, Zamiri, Mozheh, Martin, Patricia E.

“…Background: Psoriasis, a chronic inflammatory disease affecting 2–3% of the population, is characterised by epidermal hyperplasia, a sustained pro-inflammatory…”
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Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis by CAPON, Francesca, DI MEGLIO, Paola, LANCHBURY, Jerry, BARKER, Jonathan N, TREMBATH, Richard C, NESTLE, Frank O, SZAUB, Joanna, PRESCOTT, Natalie J, DUNSTER, Christina, BAUMBER, Laura, TIMMS, Kirsten, GUTIN, Alexander, ABKEVIC, Victor, BURDEN, A. David

“…Psoriasis is an inflammatory skin disorder that is inherited as a multifactorial trait. Genetic analyses have repeatedly identified a primary disease…”
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Spesolimab Efficacy and Safety in Patients with Moderate-to-Severe Palmoplantar Pustulosis: A Multicentre, Double-Blind, Randomised, Placebo-Controlled, Phase IIb, Dose-Finding Study by Burden, A. David, Bissonnette, Robert, Navarini, Alexander A., Murakami, Masamoto, Morita, Akimichi, Haeufel, Thomas, Ye, Binqi, Baehner, Frank, Terui, Tadashi

“…Introduction We evaluated the anti-interleukin-36 receptor antibody spesolimab in patients with moderate-to-severe palmoplantar pustulosis (PPP). Methods This…”
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Loss of IL36RN Function Does Not Confer Susceptibility to Psoriasis Vulgaris by Berki, Dorottya M., Mahil, Satveer K., David Burden, A., Trembath, Richard C., Smith, Catherine H., Capon, Francesca, Barker, Jonathan N.

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Effect of different classes of gadolinium-based contrast agents on control and nephrogenic systemic fibrosis-derived fibroblast proliferation by Edward, Michael, Quinn, Jean A, Burden, A David, Newton, Ben B, Jardine, Alan G

“…To determine the ability of different types of gadolinium-based contrast agents (GBCAs) to stimulate fibroblast proliferation in monolayer cell culture. The…”
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Clinical course, treatment and management of generalised pustular psoriasis from a United Kingdom extension of a global Delphi panel by Barker, Jonathan N., Becher, Gabrielle, Burden, David A., Pink, Andrew E., Zacharioudaki, Maria, Warren, Richard B.

“…This article presents the results of the UK extension of a previously conducted global Delphi panel on generalised pustular psoriasis (GPP). Five UK based…”
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