Search Results - "Burdach, Stefan E."

Current State of Immunotherapy and Mechanisms of Immune Evasion in Ewing Sarcoma and Osteosarcoma by Evdokimova, Valentina, Gassmann, Hendrik, Radvanyi, Laszlo, Burdach, Stefan E G

“…We argue here that in many ways, Ewing sarcoma (EwS) is a unique tumor entity and yet, it shares many commonalities with other immunologically cold solid…”
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DNA Microarrays reveal relationship of ewing family tumors to both endothelial and fetal neural crest-derived cells and define novel targets by STAEGE, Martin S, HUTTER, Christoph, NEUMANN, Ingo, FOJA, Sabine, HATTENHORST, Uwe E, HANSEN, Gesine, AFAR, Danny, BURDACH, Stefan E. G

“…Ewing family tumors (EFTs) are small round blue cell tumors that show features of neuroectodermal differentiation. However, the histogenetic origin of EFTs is…”
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Precision medicine in pediatric oncology by Burdach, Stefan E. G., Westhoff, Mike-Andrew, Steinhauser, Maximilian Felix, Debatin, Klaus-Michael

“…Outcome in treatment of childhood cancers has improved dramatically since the 1970s. This success was largely achieved by the implementation of cooperative…”
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Correction to: Precision medicine in pediatric oncology by Burdach, Stefan E. G., Westhoff, Mike-Andrew, Steinhauser, Maximilian Felix, Debatin, Klaus-Michael

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T Cells Directed against the Metastatic Driver Chondromodulin-1 in Ewing Sarcoma: Comparative Engineering with CRISPR/Cas9 vs. Retroviral Gene Transfer for Adoptive Transfer by Xue, Busheng, von Heyking, Kristina, Gassmann, Hendrik, Poorebrahim, Mansour, Thiede, Melanie, Schober, Kilian, Mautner, Josef, Hauer, Julia, Ruland, Jürgen, Busch, Dirk H, Thiel, Uwe, Burdach, Stefan E G

“…Ewing sarcoma (EwS) is a highly malignant sarcoma of bone and soft tissue with early metastatic spread and an age peak in early puberty. The prognosis in…”
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Ewing Sarcoma-Derived Extracellular Vesicles Impair Dendritic Cell Maturation and Function by Gassmann, Hendrik, Schneider, Kira, Evdokimova, Valentina, Ruzanov, Peter, Schober, Sebastian J., Xue, Busheng, von Heyking, Kristina, Thiede, Melanie, Richter, Guenther H. S., Pfaffl, Michael W., Noessner, Elfriede, Stein, Lincoln D., Sorensen, Poul H., Burdach, Stefan E. G., Thiel, Uwe

“…Ewing sarcoma (EwS) is an aggressive pediatric cancer of bone and soft tissues characterized by scant T cell infiltration and predominance of immunosuppressive…”
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MHC Class I-Restricted TCR-Transgenic CD4 + T Cells Against STEAP1 Mediate Local Tumor Control of Ewing Sarcoma In Vivo by Schober, Sebastian J, Thiede, Melanie, Gassmann, Hendrik, Prexler, Carolin, Xue, Busheng, Schirmer, David, Wohlleber, Dirk, Stein, Stefanie, Grünewald, Thomas G P, Busch, Dirk H, Richter, Guenther H S, Burdach, Stefan E G, Thiel, Uwe

“…In this study we report the functional comparison of T cell receptor (TCR)-engineered major histocompatibility complex (MHC) class I-restricted CD4 versus CD8…”
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Ewing sarcoma partial regression without GvHD by chondromodulin-I/HLA-A02:01-specific allorestricted T cell receptor transgenic T cells by Thiel, Uwe, Schober, Sebastian J., Einspieler, Ingo, Kirschner, Andreas, Thiede, Melanie, Schirmer, David, Gall, Katja, Blaeschke, Franziska, Schmidt, Oxana, Jabar, Susanne, Ranft, Andreas, Alba Rubío, Rebeca, Dirksen, Uta, Grunewald, Thomas G. P., Sorensen, Poul H., Richter, Günther H. S., von Lüttichau, Irene Teichert, Busch, Dirk H., Burdach, Stefan E. G.

“…Background: Chondromodulin-I (CHM1) sustains malignancy in Ewing sarcoma (ES). Refractory ES carries a dismal prognosis and patients with bone marrow (BM)…”
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The Oncolytic Adenovirus XVir-N-31 Joins Forces with CDK4/6 Inhibition Augmenting Innate and Adaptive Antitumor Immunity in Ewing Sarcoma by Schober, Sebastian Johannes, Schoening, Caroline, Eck, Jennifer, Middendorf, Charlotte, Lutsch, Julia, Knoch, Pia, von Ofen, Anna Josefine, Gassmann, Hendrik, Thiede, Melanie, Hauer, Julia, Kolk, Andreas, Mantwill, Klaus, Gschwend, Jürgen E, Burdach, Stefan E G, Nawroth, Roman, Thiel, Uwe, Holm, Per Sonne

“…Ewing sarcoma (EwS) is a highly malignant pediatric tumor characterized by a non-T-cell-inflamed immune-evasive phenotype. When relapsed or metastasized,…”
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Oncogenic ETS fusions promote DNA damage and proinflammatory responses via pericentromeric RNAs in extracellular vesicles by Ruzanov, Peter, Evdokimova, Valentina, Pachva, Manideep C, Minkovich, Alon, Zhang, Zhenbo, Langman, Sofya, Gassmann, Hendrik, Thiel, Uwe, Orlic-Milacic, Marija, Zaidi, Syed H, Peltekova, Vanya, Heisler, Lawrence E, Sharma, Manju, Cox, Michael E, McKee, Trevor D, Zaidi, Mark, Lapouble, Eve, McPherson, John D, Delattre, Olivier, Radvanyi, Laszlo, Burdach, Stefan Eg, Stein, Lincoln D, Sorensen, Poul H

“…Aberrant expression of the E26 transformation-specific (ETS) transcription factors characterizes numerous human malignancies. Many of these proteins, including…”
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MondoA drives malignancy in B-ALL through enhanced adaptation to metabolic stress by Sipol, Alexandra, Hameister, Erik, Xue, Busheng, Hofstetter, Julia, Barenboim, Maxim, Öllinger, Rupert, Jain, Gaurav, Prexler, Carolin, Rubio, Rebeca Alba, Baldauf, Michaela C., Franchina, Davide G., Petry, Andreas, Schmäh, Juliane, Thiel, Uwe, Görlach, Agnes, Cario, Gunnar, Brenner, Dirk, Richter, Günther H.S., Grünewald, Thomas G.P., Rad, Roland, Wolf, Elmar, Ruland, Jürgen, Sorensen, Poul H., Burdach, Stefan E.G.

“…Cancer cells are in most instances characterized by rapid proliferation and uncontrolled cell division. Hence, they must adapt to proliferation-induced…”
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Cleavage of the Ewing Tumour-specific EWSR1-FLI1 mRNA by Hammerhead Ribozymes by HÜHN, Regina, STAEGE, Martin S, HESSE, Manuela, LIEBIG, Beate, BURDACH, Stefan E. G

“…Background: Ewing family tumours (EFT) are the second most common bone tumours in children and adolescents. In the majority of EFT, EWSR1-FLI1 (Ewing sarcoma…”
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Bone marrow involvement identifies a subgroup of advanced Ewing sarcoma patients with fatal outcome irrespective of therapy in contrast to curable patients with multiple bone metastases but unaffected marrow by Thiel, Uwe, Wawer, Angela, von Luettichau, Irene, Bender, Hans-Ulrich, Blaeschke, Franziska, Grunewald, Thomas G P, Steinborn, Marc, Röper, Barbara, Bonig, Halvard, Klingebiel, Thomas, Bader, Peter, Koscielniak, Ewa, Paulussen, Michael, Dirksen, Uta, Juergens, Heribert, Kolb, Hans-Jochem, Burdach, Stefan E G

“…Advanced Ewing sarcomas have poor prognosis. They are defined by early relapse (<24 months after diagnosis) and/or by metastasis to multiple bones or bone…”
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Abstract 5000: YB-1 based oncolytic virotherapy in combination with small molecular inhibitors for treatment of refractory osteosarcoma by Middendorf, Charlotte Friederike, Schober, Sebastian Johannes, Kordass, Corazón, Nawroth, Roman, Burdach, Stefan E., Holm, Per Sonne, Thiel, Uwe

“…This in vitro study evaluates YB-1 based oncolytic virotherapy in combination with molecular target therapy as a novel therapeutic strategy for refractory…”
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Abstract LB-106: Allorepertoire-derived HLA class I/peptide-specific T cell receptor transgenic CD4+ T cells mediate antitumor responses in Ewing sarcoma mimicking allo-rejection by Schober, Sebastian J., Thiede, Melanie, Schirmer, David, Wohlleber, Dirk, Richter, Guenther, Busch, Dirk H., Thiel, Uwe, Burdach, Stefan E.

“…Introduction: Innovative therapies are urgently warranted to cure patients with advanced Ewing sarcoma (ES). Specific cellular-based approaches for…”
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Donor lymphocyte infusions in adolescents and young adults for control of advanced pediatric sarcoma by Schober, Sebastian J, von Luettichau, Irene, Wawer, Angela, Steinhauser, Maximilian, Salat, Christoph, Schwinger, Wolfgang, Ussowicz, Marek, Antunovic, Petar, Castagna, Luca, Kolb, Hans-Jochem, Burdach, Stefan E G, Thiel, Uwe

“…Allogeneic stem cell transplantation (allo-SCT) and donor lymphocyte infusions (DLI) may induce a graft-versus-tumor effect in pediatric sarcoma patients…”
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A costimulatory chimeric antigen receptor targeting TROP2 enhances the cytotoxicity of NK cells expressing a T cell receptor reactive to human papillomavirus type 16 E7 by Poorebrahim, Mansour, Quiros-Fernandez, Isaac, Marmé, Frederik, Burdach, Stefan EG, Cid-Arregui, Angel

“…Immune cells modified to express a tumor-reactive T cell receptor (TCR) have shown limited efficacy as stand-alone therapy against solid tumors. Genital and…”
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Abstract B058: Clusterin overexpression in therapeutic T cell induces resistance to exhaustion by Segner, Constantin, Kolesnikova, Alisa, Poorebrahim, Mansour, Höbart, Julia, Schulz, Miriam, Xue, Busheng, Brückner, Christian, Madeira, Alissia Fernandes, Hauer, Julia, Ruland, Jürgen, Sorensen, Poul H., Burdach, Stefan EG

“…Ewing Sarcoma (EwS) is characterized by an immunosuppressive tumor microenvironment (TME), which promotes T cell exhaustion, among other factors by chronic…”
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Treatment of progressive or recurrent pediatric malignant supratentorial brain tumors with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration by PACKER, R. J, RAFFEL, C, KAPCALA, L. P, VILLABLANCA, J. G, TONN, J.-C, BURDACH, S. E, BURGER, K, LAFOND, D, MCCOMB, J. G, COGEN, P. H, VEZINA, G

“…The outcome for children with recurrent malignant brain tumors is poor. The majority of patients die of progressive disease within months of relapse, and other…”
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Granulocyte-macrophage-colony stimulating factor for prevention of neutropenia and infections in children and adolescents with solid tumors. Results of a prospective randomized study by Burdach, S E, Müschenich, M, Josephs, W, Frisch, J, Schulz, G, Jürgens, H, Göbel, U

“…Chemotherapy is an essential modality of curative strategies in pediatric oncology. Dose and dose intensity are, above all, restricted by the myelosuppressive…”
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