Search Results - "Burczynski, J."

Recent insights into the biological functions of liver fatty acid binding protein 1 by Wang, GuQi, Bonkovsky, Herbert L., de Lemos, Andrew, Burczynski, Frank J.

“…Over four decades have passed since liver fatty acid binding protein (FABP)1 was first isolated. There are few protein families for which most of the complete…”
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The Role of Extracellular Binding Proteins in the Cellular Uptake of Drugs: Impact on Quantitative In Vitro-to-In Vivo Extrapolations of Toxicity and Efficacy in Physiologically Based Pharmacokinetic-Pharmacodynamic Research by Poulin, Patrick, Burczynski, Frank J, Haddad, Sami

“…A critical component in the development of physiologically based pharmacokinetic-pharmacodynamic (PBPK/PD) models for estimating target organ dosimetry in…”
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Multiphoton microscopy in defining liver function by Thorling, Camilla A, Crawford, Darrell, Burczynski, Frank J, Liu, Xin, Liau, Ian, Roberts, Michael S

“…Multiphoton microscopy is the preferred method when in vivo deep-tissue imaging is required. This review presents the application of multiphoton microscopy in…”
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Antioxidative function of L-FABP in L-FABP stably transfected chang liver cells by GUQI WANG, YUEWEN GONG, ANDERSON, Judy, DONGFENG SUN, MINUK, Gerald, ROBERTS, Michael S, BURCZYNSKI, Frank J

“…Liver fatty acid binding protein (L-FABP) contains amino acids that are known to possess antioxidant function. In this study, we tested the hypothesis that…”
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Enterohepatic circulation: Physiological, pharmacokinetic and clinical implications by ROBERTS, Michael S, MAGNUSSON, Beatrice M, BURCZYNSKI, Frank J, WEISS, Michael

“…Enterohepatic recycling occurs by biliary excretion and intestinal reabsorption of a solute, sometimes with hepatic conjugation and intestinal deconjugation…”
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Inhibition of BMP4 and Alpha Smooth Muscle Actin Expression in LX-2 Hepatic Stellate Cells by BMP4-siRNA Lipid Based Nanoparticle by Omar, Refaat, Yang, Jiaqi, Alrushaid, Samaa, Burczynski, Frank J, Minuk, Gerald Y, Gong, Yuewen

“…To develop and characterize vitamin A (VA)-coupled liposomes for the targeted delivery of BMP4-siRNA to hepatic stellate cells (HSC). VA was selected to…”
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Clofibrate Attenuates ROS Production by Lipid Overload in Cultured Rat Hepatoma Cells by Chen, Yufei, Li, Wei, Wang, Guqi, Burczynski, Frank J

“…To investigate the effect of clofibrate on inducing liver fatty acid binding protein (FABP1) following a high-fat load in a hepatocyte cell culture model. Rat…”
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Molecular mechanism of recombinant liver fatty acid binding protein's antioxidant activity by Yan, Jing, Gong, Yuewen, She, Yi-Min, Wang, Guqi, Roberts, Michael S., Burczynski, Frank J.

“…Hepatocytes expressing liver fatty acid binding protein (L-FABP) are known to be more resistant to oxidative stress than those devoid of this protein. The…”
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Nitric oxide donors improve prednisone effects on muscular dystrophy in the mdx mouse diaphragm by Mizunoya, Wataru, Upadhaya, Ritika, Burczynski, Frank J, Wang, Guqi, Anderson, Judy E

“…In Duchenne muscular dystrophy (DMD), palliative glucocorticoid therapy can produce myopathy or calcification. Since increased nitric oxide synthase activity…”
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Pharmacokinetic and Toxicodynamic Characterization of a Novel Doxorubicin Derivative by Alrushaid, Samaa, Sayre, Casey L, Yáñez, Jaime A, Forrest, M Laird, Senadheera, Sanjeewa N, Burczynski, Frank J, Löbenberg, Raimar, Davies, Neal M

“…Doxorubicin (Dox) is an effective anti-cancer medication with poor oral bioavailability and systemic toxicities. DoxQ was developed by conjugating Dox to the…”
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The Antioxidant Activity of Recombinant Rat Hepatic Fatty Acid Binding Protein T94A Variant by Le, Tyson, Gong, Yuewen, Davies, Neal M, Lillico, Ryan, Lakowski, Ted, Roberts, Michael S, Burczynski, Frank J

“…Liver fatty acid binding protein (FABP1) is a cytoplasmic polypeptide that transports substrates throughout the cytosol and functions as an antioxidant. A…”
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Pharmaceutical Characterization of MyoNovin, a Novel Skeletal Muscle Regenerator: in silico, in vitro and in vivo Studies by Alrushaid, Samaa, Davies, Neal M, Anderson, Judy E, Le, Tyson, Yáñez, Jaime A, Maayah, Zaid H, El-Kadi, Ayman O S, Rachid, Ousama, Sayre, Casey L, Löbenberg, Raimar, Burczynski, Frank J

“…MyoNovin is a novel skeletal muscle-regenerating compound developed through synthesis of two nitro groups onto a guaifenesin backbone to deliver nitric oxide…”
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Hepatoprotective role of liver fatty acid binding protein in acetaminophen induced toxicity by Gong, Yu, Wang, Guqi, Gong, Yuewen, Yan, Jing, Chen, Yufei, Burczynski, Frank J

“…FABP1 has been reported to possess strong antioxidant properties. Upon successful transfection of the Chang cell line, which has undetectable FABP1 mRNA…”
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Effects of long-term hepatic ischemia-reperfusion injury on the function of P-glycoprotein in vivo in rats by Thorling, Camilla A, Roberts, Michael S, Liu, Xin, Fletcher, Linda M, Crawford, Darrell, Burczynski, Frank J

“…Ischemia-reperfusion injury is a common complication in liver surgery with oxidative stress related graft failure as a potential complication. The oxidative…”
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Metabolic Disposition of the Insect Repellent DEET and the Sunscreen Oxybenzone Following Intravenous and Skin Administration in Rats by Fediuk, Daryl J., Wang, Tao, Chen, Yufei, Parkinson, Fiona E., Namaka, Michael P., Simons, Keith J., Burczynski, Frank J., Gu, Xiaochen

“…Insect repellent N,N-diethyl-m-toluamide (DEET) and sunscreen oxybenzone have shown a synergistic percutaneous enhancement when applied concurrently. Both…”
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Role of cytosolic liver fatty acid binding protein in hepatocellular oxidative stress: effect of dexamethasone and clofibrate treatment by Rajaraman, G, Wang, G Q, Yan, J, Jiang, P, Gong, Y, Burczynski, F J

“…The presence of cysteine and methionine groups together with an ability to bind long-chain fatty acid (LCFA) oxidation products makes liver fatty acid binding…”
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Fluorescent fatty acid transfer from bovine serum albumin to phospholipid vesicles: collision or diffusion mediated uptake by Elmadhoun, Bassam M, Swairjo, Manal A, Burczynski, Frank J

“…The extent of palmitate uptake by hepatocytes is dependent upon the surface charge of the extracellular binding protein. Specifically, hepatocyte uptake is…”
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Safety and efficacy of an ocular insert for apomorphine-induced emesis in dogs by Cote, Dennis D, Collins, David M, Burczynski, Frank J

“…To evaluate the safety and efficacy of an ocular insert designed to provide controlled release of apomorphine for the induction of emesis in dogs. 5,001 dogs…”
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In vitro evaluation of concurrent use of commercially available insect repellent and sunscreen preparations by Gu, X., Wang, T., Collins, D.M., Kasichayanula, S., Burczynski, F.J.

“…Summary Background  Insect repellents and sunscreens are over‐the‐counter products extensively used by the general public. Concurrent application of these…”
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METABOLISM OF THE CARDIOPROTECTIVE DRUG DEXRAZOXANE AND ONE OF ITS METABOLITES BY ISOLATED RAT MYOCYTES, HEPATOCYTES, AND BLOOD by SCHROEDER, Patricia E, WANG, Gu-Qi, BURCZYNSKI, Frank J, HASINOFF, Brian B

“…The metabolism of the antioxidant cardioprotective agent dexrazoxane (ICRF-187) and one of its one-ring open metabolites to its active metal ion binding form N…”
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