Search Results - "Burckhardt, Bjoern B."

Sensitive mass spectrometric determination of kinin-kallikrein system peptides in light of COVID-19 by Gangnus, Tanja, Burckhardt, Bjoern B.

“…The outbreak of COVID-19 has raised interest in the kinin–kallikrein system. Viral blockade of the angiotensin-converting enzyme 2 impedes degradation of the…”
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Recent advances in the discovery and development of drugs targeting the kallikrein-kinin system by Wisniewski, Petra, Gangnus, Tanja, Burckhardt, Bjoern B

“…The kallikrein-kinin system is a key regulatory cascade involved in blood pressure maintenance, hemostasis, inflammation and renal function. Currently,…”
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Mass spectrometric study of variation in kinin peptide profiles in nasal fluids and plasma of adult healthy individuals by Gangnus, Tanja, Bartel, Anke, Burckhardt, Bjoern B

“…The kallikrein-kinin system is assumed to have a multifunctional role in health and disease, but its in vivo role in humans currently remains unclear owing to…”
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Reliable measurement of plasma kinin peptides: Importance of preanalytical variables by Gangnus, Tanja, Burckhardt, Bjoern B.

“…The kallikrein‐kinin system is involved in many (patho)physiological processes and kinin peptides are considered potential clinical biomarkers. Variance in…”
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Embedding a Sensitive Liquid-Core Waveguide UV Detector into an HPLC-UV System for Simultaneous Quantification of Differently Dosed Active Ingredients during Drug Release by Chamberlain, Rebecca, Windolf, Hellen, Burckhardt, Bjoern B, Breitkreutz, Jörg, Fischer, Björn

“…Individual dosing of pharmaceutics and personalized medicine have become important with regard to therapeutic safety. Dose adjustments, biorelevant drug…”
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Formulation Development of Sublingual Cyclobenzaprine Tablets Empowered by Standardized and Physiologically Relevant Ex Vivo Permeation Studies by Majid, Haidara, Puzik, Andreas, Maier, Tanja, Merk, Raphaela, Bartel, Anke, Mueller, Hans-Christian, Burckhardt, Bjoern

“…Suitable ex vivo models are required as predictive tools of oromucosal permeability between in vitro characterizations and in vivo studies in order to support…”
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Potential and Limitations of Atrial Natriuretic Peptide as Biomarker in Pediatric Heart Failure-A Comparative Review by Gangnus, Tanja, Burckhardt, Bjoern B

“…Although B-type Natriuretic Peptide (BNP), N-terminal-proBNP (NT-proBNP), and mid-regional-proANP (MR-proANP) are included in current guidelines on heart…”
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Development and evaluation of a composite dosage form containing desmopressin acetate for buccal administration by Kottke, Dina, Burckhardt, Bjoern B., Knaab, Tanja C., Breitkreutz, Jörg, Fischer, Björn

“…Desmopressin acetate (DDAVP) is an oligopeptide indicated for the treatment of primary nocturnal enuresis, for example. The poor oral bioavailability of DDAVP…”
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Total Synthesis of the Antimycobacterial Natural Product Chlorflavonin and Analogs via a Late-Stage Ruthenium(II)-Catalyzed ortho-C(sp2)-H-Hydroxylation by Berger, Alexander, Knak, Talea, Kiffe-Delf, Anna-Lene, Mudrovcic, Korana, Singh, Vinayak, Njoroge, Mathew, Burckhardt, Bjoern B., Gopalswamy, Mohanraj, Lungerich, Beate, Ackermann, Lutz, Gohlke, Holger, Chibale, Kelly, Kalscheuer, Rainer, Kurz, Thomas

“…The continuous, worldwide spread of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) endanger the World Health Organization’s…”
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Dysregulation of the kallikrein-kinin system in bronchoalveolar lavage fluid of patients with severe COVID-19 by Martens, Caroline P., Van Mol, Pierre, Wauters, Joost, Wauters, Els, Gangnus, Tanja, Noppen, Bernard, Callewaert, Hanne, Feyen, Jean H.M., Liesenborghs, Laurens, Heylen, Elisabeth, Jansen, Sander, Pereira, Leydi Carolina Velásquez, Kraisin, Sirima, Guler, Ipek, Engelen, Matthias M., Ockerman, Anna, Van Herck, Anke, Vos, Robin, Vandenbriele, Christophe, Meersseman, Philippe, Hermans, Greet, Wilmer, Alexander, Martinod, Kimberly, Burckhardt, Bjoern B., Vanhove, Marc, Jacquemin, Marc, Verhamme, Peter, Neyts, Johan, Vanassche, Thomas

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the angiotensin-converting enzyme 2 (ACE2) receptor, a critical component of the…”
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Self-Instruction Video Versus Face-to-Face Instruction of Pharmacy Students’ Skills in Blood Pressure Measurement by Farahani, Samieh, Farahani, Imaneh, Burckhardt, Bjoern B., Schwender, Holger, Laeer, Stephanie

“…A modern approach to clinical skill education is the use of educational videos, yet there is a shortage of literature investigating the effect of…”
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Enalapril and Enalaprilat Pharmacokinetics in Children with Heart Failure Due to Dilated Cardiomyopathy and Congestive Heart Failure after Administration of an Orodispersible Enalapril Minitablet (LENA-Studies) by Laeer, Stephanie, Cawello, Willi, Burckhardt, Bjoern B., Ablonczy, László, Bajcetic, Milica, Breur, Johannes M. P. J., Dalinghaus, Michiel, Male, Christoph, de Wildt, Saskia N., Breitkreutz, Jörg, Faisal, Muhammed, Keatley-Clarke, Anne, Klingmann, Ingrid, Lagler, Florian B.

“…Angiotensin-converting enzyme inhibitors (ACEI), such as enalapril, are a cornerstone of treatment for pediatric heart failure which is still used off-label…”
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Simulation Training to Improve Informed Consent and Pharmacokinetic/Pharmacodynamic Sampling in Pediatric Trials by Burckhardt, Bjoern B, Ciplea, Agnes Maria, Laven, Anna, Ablonczy, László, Klingmann, Ingrid, Läer, Stephanie, Kleine, Karl, Dalinghaus, Michiel, Đukić, Milan, Breur, Johannes M P J, van der Meulen, Marijke, Swoboda, Vanessa, Schwender, Holger, Lagler, Florian B

“…: Pediatric trials to add missing data for evidence-based pharmacotherapy are still scarce. A tailored training concept appears to be a promising tool to cope…”
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Improving sensitivity for the targeted LC-MS/MS analysis of the peptide bradykinin using a design of experiments approach by Gangnus, Tanja, Burckhardt, Bjoern B.

“…The nonapeptide bradykinin is endogenously present only in low picomolar plasma concentrations, subsequently making reliable detection using liquid…”
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Picomolar Sensitivity Analysis of Multiple Bradykinin-Related Peptides in the Blood Plasma of Patients With Hereditary Angioedema in Remission: A Pilot Study by Marceau, François, Rivard, Georges-Etienne, Hébert, Jacques, Gauthier, Julie, Bachelard, Hélène, Gangnus, Tanja, Burckhardt, Bjoern B

“…Hereditary angioedema (HAE) is a rare autosomal dominant disease; the most well understood forms concern the haplodeficiency of C1 esterase inhibitor (C1INH)…”
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Targeted LC-MS/MS platform for the comprehensive determination of peptides in the kallikrein-kinin system by Gangnus, Tanja, Burckhardt, Bjoern B.

“…The kallikrein-kinin system (KKS) is involved in many physiological and pathophysiological processes and is assumed to be connected to the development of…”
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Predictivity of standardized and controlled permeation studies: Ex vivo – In vitro – In vivo correlation for sublingual absorption of propranolol by Majid, Haidara, Bartel, Anke, Burckhardt, Bjoern B.

“…[Display omitted] •Assessment of the predictivity of standardized ex vivo vs. in vitro permeation studies.•Successful proof of concept for evaluation of…”
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Orodispersible minitablets of enalapril for use in children with heart failure (LENA): Rationale and protocol for a multicentre pharmacokinetic bridging study and follow-up safety study by Bajcetic, Milica, de Wildt, Saskia N, Dalinghaus, Michiel, Breitkreutz, Jörg, Klingmann, Ingrid, Lagler, Florian B, Keatley-Clarke, Anne, Breur, Johannes MPJ, Male, Christoph, Jovanovic, Ida, Szatmári, Andras, Ablonczy, László, Burckhardt, Bjoern B, Cawello, Willi, Kleine, Karl, Obarcanin, Emina, Spatenkova, Lucie, Swoboda, Vanessa, van der Meulen, Marijke, Wagner, Peter, Walsh, Jennifer, Läer, Stephanie

“…AbstractIntroductionTreatment of paediatric heart failure is based on paradigms extensively tested in the adult population assuming similar underlying…”
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Sample Preparation and Extraction in Small Sample Volumes Suitable for Pediatric Clinical Studies: Challenges, Advances, and Experiences of a Bioanalytical HPLC-MS/MS Method Validation Using Enalapril and Enalaprilat by Burckhardt, Bjoern B., Laeer, Stephanie

“…In USA and Europe, medicines agencies force the development of child-appropriate medications and intend to increase the availability of information on the…”
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Substance P in cardiovascular diseases – A bioanalytical review by Feickert, Martin, Burckhardt, Bjoern B.

“…Substance P has recently received much attention as a mediator of adverse heart remodelling and cardiac inflammation by releasing proinflammatory cytokines and…”
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