Search Results - "Burchell, B"

In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance by Soars, M G, Burchell, B, Riley, R J

“…The glucuronidation of a number of commonly used hepatic uridine diphosphate glucuronosyltransferase drug substrates has been studied in human tissue…”
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Molecular genetic basis of Gilbert's syndrome by Burchell, B, Hume, R

“…Gilbert’s syndrome, an hereditary, chronic, mild, unconjugated hyperbilirubinaemia resulting from impaired hepatic bilirubin clearance and otherwise normal…”
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Substrate specificities of two stably expressed human liver UDP-glucuronosyltransferases of the UGT1 gene family by Ebner, T, Burchell, B

“…Two cloned human hepatic UDP-glucuronosyltransferase (UGT) cDNAs were stably expressed in chinese hamster V79 cells. More than 100 drugs and xenobiotics were…”
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ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2 by Jedlitschky, G, Leier, I, Buchholz, U, Hummel-Eisenbeiss, J, Burchell, B, Keppler, D

“…Bilirubin is secreted from the liver into bile mainly as monoglucuronosyl and bisglucuronosyl conjugates. We demonstrate for the first time that ATP-dependent…”
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Investigation of the substrate specificity of a cloned expressed human bilirubin UDP-glucuronosyltransferase: UDP-sugar specificity and involvement in steroid and xenobiotic glucuronidation by Senafi, S B, Clarke, D J, Burchell, B

“…A cloned human bilirubin UDP-glucuronosyltransferase (UGT) stably expressed in Chinese hamster V79 cells was used to assess the substrate specificity of the…”
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Genetic and Environmental Factors Associated with Variation of Human Xenobiotic Glucuronidation and Sulfation by Burchell, Brian, Michael W. H. Coughtrie

“…Glucuronidation and sulfation are phase 2 metabolic reactions catalyzed by large families of different isoenzymes in man. The textbook view that…”
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Genetic and Environmental Factors Associated with Variation of Human Xenobiotic Glucuronidation and Sulfation by Burchell, Brian, Coughtrie, Michael W. H.

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Characterization of the uridine diphosphate-glucuronosyltransferase-catalyzing thyroid hormone glucuronidation in man by FINDLAY, K. A. B, KAPTEIN, E, VISSER, T. J, BURCHELL, B

“…Increased thyroid hormone glucuronidation in rats caused by exposure to xenobiotics has stimulated a search for the individual uridine…”
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The quality of employment and decent work: definitions, methodologies, and ongoing debates by Burchell, Brendan, Sehnbruch, Kirsten, Piasna, Agnieszka, Agloni, Nurjk

“…This article explores the development of concepts related to the 'quality of employment' in the academic literature in terms of their definition,…”
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Trust, business relationships and the contractual environment by Burchell, Brendan, Wilkinson, Frank

“…The role of trust in vertical contractual relationships between firms in Britain, Germany and Italy is investigated with a survey of over 60 firms. After a…”
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Human bilirubin UDP-glucuronosyltransferase catalyzes the glucuronidation of ethinylestradiol by Ebner, T, Remmel, R P, Burchell, B

“…The synthetic estrogen ethinylestradiol is extensively eliminated as glucuronide metabolites in humans, but the UDP-glucuronosyltransferases (UGTs) catalyzing…”
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Cloning and Characterization of a Canine UDP-Glucuronosyltransferase by Soars, M.G., Smith, D.J., Riley, R.J., Burchell, B.

“…UDP-glucuronosyltransferases (UGTs) are a major family of enzymes catalyzing the transfer of glucuronic acid to a range of endogenous compounds and xenobiotics…”
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Expression of a functionally active human hepatic UDP-glucuronosyltransferase (UGT1A6) lacking the N-terminal signal sequence in the endoplasmic reticulum by Ouzzine, M., Magdalou, J., Burchell, B., Fournel-Gigleux, S.

“…UDP-glucuronosyltransferase 1A6 (UGT1A6) is a membrane glycoprotein of the endoplasmic reticulum playing a key role in drug metabolism. It is synthesized as a…”
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Cloning and stable expression of a new member of the human liver phenol/bilirubin : UDP-glucuronosyltransferase cDNA family by WOOSTER, SUTHERLAND, L, EBNER, T, CLARKE, D, DA CRUZ E SILVA, O, BURCHELL, B

“…A new human liver UDP-glucuronosyltransferase (HlugP4) has been cloned and expressed in cell culture. The expressed enzyme has a molecular mass of 56 kDa and…”
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The inadequacy of perinatal glucuronidation: immunoblot analysis of the developmental expression of individual UDP-glucuronosyltransferase isoenzymes in rat and human liver microsomes by Coughtrie, M W, Burchell, B, Leakey, J E, Hume, R

“…Two anti-rat UDP-glucuronosyltransferase (UDPGT) antibody preparations, exhibiting different specificity of recognition of UDPGT isoenzymes on immunoblot…”
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Cloning and Substrate Specificity of a Human Phenol UDP-Glucuronosyltransferase Expressed in COS-7 Cells by Harding, David, Fournel-Gigleux, Sylvie, Jackson, Michael R., Burchell, Brian

“…A rat kidney phenol UDP-glucuronosyltransferase cDNA was used to isolate a human liver phenol UDP-glucuronosyltransferase cDNA by screening of a human liver…”
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Osler, used and abused—an eponymic essay by Pierach, Claus A., Burchell, Howard B.

“…The controversy about the use of eponyms lingers on. A name frequently used and occasionall abused it that of Sir William Olser…”
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Reactivity of mefenamic acid 1-o-acyl glucuronide with proteins in vitro and ex vivo by McGurk, K A, Remmel, R P, Hosagrahara, V P, Tosh, D, Burchell, B

“…Mefenamic acid is a nonsteroidal anti-inflammatory drug commonly used in analgesia. The use of this drug has been implicated in several cases of nephrotoxicity…”
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Almokalant glucuronidation in human liver and kidney microsomes: evidence for the involvement of UGT1A9 and 2B7 by Gaiser, B. K., Lockley, D. J., Staines, A. G., Baarnhielm, C., Burchell, B.

“…1. Almokalant, a class III antiarrythmic drug, is metabolized to form isomeric glucuronides identified in human urine. Synthesis of the total glucuronide was…”
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Equal Pay as a Moving Target: International perspectives on forty-years of addressing the gender pay gap by O'Reilly, Jacqueline, Smith, Mark, Deakin, Simon, Burchell, Brendan

“…This paper provides an overview of the key factors impacting upon the gender pay gap in the UK, Europe and Australia. Forty years after the implementation of…”
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