Search Results - "Buratto, Damiano"

Rapid Assessment of Binding Affinity of SARS-COV-2 Spike Protein to the Human Angiotensin-Converting Enzyme 2 Receptor and to Neutralizing Biomolecules Based on Computer Simulations by Buratto, Damiano, Saxena, Abhishek, Ji, Qun, Yang, Guang, Pantano, Sergio, Zonta, Francesco

“…SARS-CoV-2 infects humans and causes Coronavirus disease 2019 (COVID-19). The S1 domain of the spike glycoprotein of SARS-CoV-2 binds to human…”
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An inorganic mineral-based protocell with prebiotic radiation fitness by Dai, Shang, Xie, Zhenming, Wang, Binqiang, Ye, Rui, Ou, Xinwen, Wang, Chen, Yu, Ning, Huang, Cheng, Zhao, Jie, Cai, Chunhui, Zhang, Furong, Buratto, Damiano, Khan, Taimoor, Qiao, Yan, Hua, Yuejin, Zhou, Ruhong, Tian, Bing

“…Protocell fitness under extreme prebiotic conditions is critical in understanding the origin of life. However, little is known about protocell’s survival and…”
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Probing the electrostatic aggregation of nanoparticles with oppositely charged molecular ions by Huang, Jianxiang, Buratto, Damiano, Zhou, Ruhong

“…The co‐assembly of charged nanoparticles with oppositely charged molecular ions has emerged as a promising technique in the fabrication of nanoparticle…”
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In Silico Maturation of a Nanomolar Antibody against the Human CXCR2 by Buratto, Damiano, Wan, Yue, Shi, Xiaojie, Yang, Guang, Zonta, Francesco

“…The steady increase in computational power in the last 50 years is opening unprecedented opportunities in biology, as computer simulations of biological…”
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A pH‐responsive nanoparticle delivery system containing dihydralazine and doxorubicin‐based prodrug for enhancing antitumor efficacy by Zhang, Lianxue, Huang, Jianxiang, Buratto, Damiano, Han, Panli, Yang, Zaixing, Zhou, Ruhong

“…The efficacy of nanoparticle (NP)‐based drug delivery technology is hampered by aberrant tumor stromal microenvironments (TSMs) that hinder NP transportation…”
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Tuft cells utilize taste signaling molecules to respond to the pathobiont microbe Ruminococcus gnavus in the proximal colon by Lei, Hao, Yu, Defu, Xue, Yan-Bo, Li, Yi-Hong, Gong, Shi-Meng, Peng, Yuan-Yuan, Liu, Kai-Fang, Buratto, Damiano, Yang, Yisen, Zhang, Sai-Sai, Wu, Min, Zhou, Ruhong, Huang, Liquan

“…Tuft cells are a type of rare epithelial cells that have been recently found to utilize taste signal transduction pathways to detect and respond to various…”
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A Human-Derived Monoclonal Antibody Targeting Extracellular Connexin Domain Selectively Modulates Hemichannel Function by Ziraldo, Gaia, Buratto, Damiano, Kuang, Yuanyuan, Xu, Liang, Carrer, Andrea, Nardin, Chiara, Chiani, Francesco, Salvatore, Anna Maria, Paludetti, Gaetano, Lerner, Richard A, Yang, Guang, Zonta, Francesco, Mammano, Fabio

“…Connexin hemichannels, which are plasma membrane hexameric channels (connexons) composed of connexin protein protomers, have been implicated in a host of…”
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Inhibition of DEF‐p65 Interactions as a Potential Avenue to Suppress Tumor Growth in Pancreatic Cancer by Huang, Sicong, Yang, Jiaqi, Xie, Teng, Jiang, Yangwei, Hong, Yifan, Liu, Xinyuan, He, Xuyan, Buratto, Damiano, Zhang, Dong, Zhou, Ruhong, Liang, Tingbo, Bai, Xueli

“…The limited success of current targeted therapies for pancreatic cancer underscores an urgent demand for novel treatment modalities. The challenge in…”
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Cues to Opening Mechanisms From in Silico Electric Field Excitation of Cx26 Hemichannel and in Vitro Mutagenesis Studies in HeLa Transfectans by Zonta, Francesco, Buratto, Damiano, Crispino, Giulia, Carrer, Andrea, Bruno, Francesca, Yang, Guang, Mammano, Fabio, Pantano, Sergio

“…Connexin channels play numerous essential roles in virtually every organ by mediating solute exchange between adjacent cells, or between cytoplasm and…”
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Nuclear Morphological Remodeling in Human Granulocytes Is Linked to Prenylation Independently from Cytoskeleton by Martewicz, Sebastian, Luni, Camilla, Zhu, Xi, Cui, Meihua, Hu, Manli, Qu, Siqi, Buratto, Damiano, Yang, Guang, Grespan, Eleonora, Elvassore, Nicola

“…Nuclear shape modulates cell behavior and function, while aberrant nuclear morphologies correlate with pathological phenotype severity. Nevertheless, functions…”
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Design and Characterization of a Human Monoclonal Antibody that Modulates Mutant Connexin 26 Hemichannels Implicated in Deafness and Skin Disorders by Xu, Liang, Carrer, Andrea, Zonta, Francesco, Qu, Zhihu, Ma, Peixiang, Li, Sheng, Ceriani, Federico, Buratto, Damiano, Crispino, Giulia, Zorzi, Veronica, Ziraldo, Gaia, Bruno, Francesca, Nardin, Chiara, Peres, Chiara, Mazzarda, Flavia, Salvatore, Anna M, Raspa, Marcello, Scavizzi, Ferdinando, Chu, Youjun, Xie, Sichun, Yang, Xuemei, Liao, Jun, Liu, Xiao, Wang, Wei, Wang, Shanshan, Yang, Guang, Lerner, Richard A, Mammano, Fabio

“…Mutations leading to changes in properties, regulation, or expression of connexin-made channels have been implicated in 28 distinct human hereditary diseases…”
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Inhibitory to non-inhibitory evolution of the ζ subunit of the F1FO-ATPase of Paracoccus denitrificans and α-proteobacteria as related to mitochondrial endosymbiosis by Mendoza-Hoffmann, Francisco, Yang, Lingyun, Buratto, Damiano, Brito-Sánchez, Jorge, Garduño-Javier, Gilberto, Salinas-López, Emiliano, Uribe-Álvarez, Cristina, Ortega, Raquel, Sotelo-Serrano, Oliver, Cevallos, Miguel Ángel, Ramírez-Silva, Leticia, Uribe-Carvajal, Salvador, Pérez-Hernández, Gerardo, Celis-Sandoval, Heliodoro, García-Trejo, José J.

“…Introduction: The ζ subunit is a potent inhibitor of the F 1 F O -ATPase of Paracoccus denitrificans (PdF 1 F O -ATPase) and related α -proteobacteria…”
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The rigidity of a structural bridge on HLA-I binding groove explains its differential outcome in cancer immune response by Zhou, Hong, Chan, Kevin Chun, Buratto, Damiano, Zhou, Ruhong

“…The tremendous success of immune checkpoint blockade (ICB) therapy has raised the great demand for the development of predictive biomarkers. A recent cancer…”
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The ζ subunit from the F1FO-ATP synthase of Sinorhizobium meliloti is pH sensitive, as revealed by 2D-NMR by Mendoza-Hoffmann, Francisco, Yang, Lingyun, Buratto, Damiano, de Jesús García-Trejo, José

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Influence of Core Topologies on Poly‑l‑lysine Dendrimer Structures by Huang, Jianxiang, Su, Yuexin, Buratto, Damiano, Song, Wei, Zhou, Zhuxian, Shen, Youqing, Zhou, Ruhong

“…Poly-l-lysine (PLL) dendrimers have emerged as promising nanomaterials for gene/drug delivery, bioimaging, and biosensing due to their high efficacy and…”
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Unveiling the Role of Mechanical Microenvironment in Hepatocellular Carcinoma: Molecular Mechanisms and Implications for Therapeutic Strategies by Hong, Jiachen, Yu, Jiongjie, Buratto, Damiano, Chen, Wei, Zhou, Ruhong, Ling, Sunbin, Xu, Xiao

“…Hepatocellular carcinoma (HCC) is the sixth most common cancer in the world and the third leading cause of cancer deaths globally. More than 80% of HCC…”
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Functionality‐Independent DNA Encoding of Complex Natural Products by Ma, Peixiang, Xu, Hongtao, Li, Jie, Lu, Fengping, Ma, Fei, Wang, Shuyue, Xiong, Huan, Wang, Wei, Buratto, Damiano, Zonta, Francesco, Wang, Nan, Liu, Kaiwen, Hua, Tian, Liu, Zhi‐Jie, Yang, Guang, Lerner, Richard A.

“…DNA encoded chemical libraries (DELs) link the powers of genetics and chemical synthesis via combinatorial optimization. Through combinatorial chemistry, DELs…”
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Selection of an ASIC1a-blocking combinatorial antibody that protects cells from ischemic death by Qiang, Min, Dong, Xue, Zha, Zhao, Zuo, Xiao-Kun, Song, Xing-Lei, Zhao, Lixia, Yuan, Chao, Huang, Chen, Tao, Pingdong, Hu, Qin, Li, Wei-Guang, Hu, Wanhui, Li, Jie, Nie, Yan, Buratto, Damiano, Zonta, Francesco, Ma, Peixiang, Yu, Zheng, Liu, Lili, Zhang, Yi, Yang, Bei, Xie, Jia, Xu, Tian-Le, Qu, Zhihu, Yang, Guang, Lerner, Richard A.

“…Acid-sensing ion channels (ASICs) have emerged as important, albeit challenging therapeutic targets for pain, stroke, etc. One approach to developing…”
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Molecular dynamics simulations highlight structural and functional alterations in deafness-related M34T mutation of connexin 26 by Zonta, Francesco, Buratto, Damiano, Cassini, Chiara, Bortolozzi, Mario, Mammano, Fabio

“…Mutations of the GJB2 gene encoding the connexin 26 (Cx26) gap junction protein, which is widely expressed in the inner ear, are the primary cause of…”
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A potent antagonist antibody targeting connexin hemichannels alleviates Clouston syndrome symptoms in mutant mice by Kuang, Yuanyuan, Zorzi, Veronica, Buratto, Damiano, Ziraldo, Gaia, Mazzarda, Flavia, Peres, Chiara, Nardin, Chiara, Salvatore, Anna Maria, Chiani, Francesco, Scavizzi, Ferdinando, Raspa, Marcello, Qiang, Min, Chu, Youjun, Shi, Xiaojie, Li, Yu, Liu, Lili, Shi, Yaru, Zonta, Francesco, Yang, Guang, Lerner, Richard A., Mammano, Fabio

“…Numerous currently incurable human diseases have been causally linked to mutations in connexin (Cx) genes. In several instances, pathological mutations…”
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