Search Results - "Buraglio, Mauro"

Investigation of the Brain Biodistribution of the Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitor [18F]GSK2647544 in Healthy Male Subjects by Huiban, Mickael, Coello, Christopher, Wu, Kai, Xu, Yanmei, Lewis, Yvonne, Brown, Andrew P., Buraglio, Mauro, Guan, Chenbing, Shabbir, Shaila, Fong, Regan, Passchier, Jan, Rabiner, Eugenii A., Lockhart, Andrew

“…Purpose GSK2647544 is a potent and specific inhibitor of lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ), which was in development as a potential…”
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Effect of hemodialysis on pharmacokinetics of ezogabine/retigabine and its N-acetyl metabolite in patients with end stage renal disease by Tompson, Debra J, Buraglio, Mauro, Bullman, Jonathan, Crean, Christopher S, Rayner, Kirsty

“…Ezogabine (EZG)/retigabine (RTG) and its metabolites are mainly eliminated renally. This Phase I study assessed the effect of hemodialysis on the…”
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Investigation of the Brain Biodistribution of the Lipoprotein-Associated Phospholipase A^sub 2^ (Lp-PLA^sub 2^) Inhibitor [^sup 18^F]GSK2647544 in Healthy Male Subjects by Huiban, Mickael, Coello, Christopher, Wu, Kai, Xu, Yanmei, Lewis, Yvonne, Brown, Andrew P, Buraglio, Mauro, Guan, Chenbing, Shabbir, Shaila, Fong, Regan, Passchier, Jan, Rabiner, Eugenii A, Lockhart, Andrew

“…Purpose GSK2647544 is a potent and specific inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2), which was in development as a potential treatment…”
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Investigation of the Brain Biodistribution of the Lipoprotein-Associated Phospholipase A sub(2) (Lp-PLA sub(2)) Inhibitor [ super(18)F]GSK2647544 in Healthy Male Subjects by Huiban, Mickael, Coello, Christopher, Wu, Kai, Xu, Yanmei, Lewis, Yvonne, Brown, Andrew P, Buraglio, Mauro, Guan, Chenbing, Shabbir, Shaila, Fong, Regan, Passchier, Jan, Rabiner, Eugenii A, Lockhart, Andrew

“…GSK2647544 is a potent and specific inhibitor of lipoprotein-associated phospholipase A sub(2) (Lp-PLA sub(2)), which was in development as a potential…”
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The effect of ezogabine on the pharmacokinetics of an oral contraceptive agent by CREAN, Christopher S, TOMPSON, Debra J, BURAGLIO, Mauro

“…Ezogabine (EZG) is a potassium-channel opener that has been approved as adjunctive treatment for partial-onset seizures in adults with epilepsy. This Phase I…”
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Adolescent Clinical Development of Ezogabine/Retigabine as Adjunctive Therapy for Partial-Onset Seizures: Pharmacokinetics and Tolerability by Tompson, Debra J, Buraglio, Mauro, Andrews, Susan M, Wheless, James W

“…To explore the pharmacokinetic (PK) profile and safety of ezogabine (EZG)/retigabine (RTG) as adjunctive therapy for uncontrolled partial-onset seizures (POS)…”
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Investigation of the Brain Biodistribution of the Lipoprotein-Associated Phospholipase A 2 (Lp-PLA 2 ) Inhibitor [ 18 F]GSK2647544 in Healthy Male Subjects by Huiban, Mickael, Coello, Christopher, Wu, Kai, Xu, Yanmei, Lewis, Yvonne, Brown, Andrew P, Buraglio, Mauro, Guan, Chenbing, Shabbir, Shaila, Fong, Regan, Passchier, Jan, Rabiner, Eugenii A, Lockhart, Andrew

“…GSK2647544 is a potent and specific inhibitor of lipoprotein-associated phospholipase A (Lp-PLA ), which was in development as a potential treatment for…”
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A phase I study of the pharmacokinetics, pharmacodynamics, and safety of single- and multiple-dose anastrozole in healthy, premenopausal female volunteers by Tredway, Donald R, Buraglio, Mauro, Hemsey, George, Denton, Geoff

“…To evaluate the pharmacokinetic, pharmacodynamic, and safety profiles of the aromatase inhibitor anastrozole in healthy, premenopausal women. Phase I,…”
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Investigation of the impact of urine handling procedures on interpretation of urinalysis findings and product safety in subjects treated with ezogabine by Brickel, Neil, Derossett, Sarah, Buraglio, Mauro, Evans, Christopher, Jones, Siôn

“…Ezogabine (also known by the international nonproprietary name of retigabine) is an antiepileptic drug codeveloped and comarketed by Valeant Pharmaceuticals…”
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Lack of effect of ezogabine/retigabine on the pharmacokinetics of digoxin in healthy individuals: results from a drug-drug interaction study by Tompson, Debra J, Crean, Christopher S, Buraglio, Mauro, Arumugham, Thangam

“…The potential for ezogabine/retigabine (EZG/RTG) and its N-acetyl metabolite (NAMR) to inhibit the transporter protein P-glycoprotein-(P-gp)-mediated digoxin…”
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No Effect of the Novel Antidiabetic Agent Nateglinide on the Pharmacokinetics and Anticoagulant Properties of Warfarin in Healthy Volunteers by Anderson, Denise M., Shelley, Sarah, Crick, Nina, Buraglio, Mauro

“…The novel hypoglycemic agent nateglinide is pharmacologically distinct from oral hypoglycemic agents such as sulfonylureas and repaglinide. The present study…”
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Population pharmacokinetics of onercept in healthy subjects by GLATT, Sophie, FUSEAU, Eliane, BURAGLIO, Mauro, NGUYEN, Quyen T. X

“…To develop a population pharmacokinetic model and to determine the covariates affecting the pharmacokinetics of onercept (recombinant human tumour necrosis…”
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Comparative pharmacokinetics and pharmacodynamics of recombinant human interferon beta-1a after intramuscular and subcutaneous administration by Munafo, Alain, Trinchard-Lugan, Isabelle, Ho-Nguyen, Thi Xuan Quyen, Buraglio, Mauro

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Lack of Effect of Food on the Bioavailability of Oral Azithromycin Tablets by Simicevic, Velimir N., Erceg, Damir, Dohoczky, Csaba, Radosevic, Senka, Spaventi, Radan, Buraglio, Mauro, Canali, Sergio, Culig, Josip

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Absence of (-) [3H]desmethoxyverapamil binding sites on human platelets and lack of evidence for voltage-dependent calcium channels by Pannocchia, A, Praloran, N, Arduino, C, Della Dora, N, Bazzan, M, Schinco, P, Buraglio, M, Pileri, A, Tamponi, G

“…The two major pathways for Ca2+ entry into cells are potential-sensitive channels and receptor-operated channels. The main object of this investigation was to…”
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Congenital deficiency of alpha-2-adrenoceptors on human platelets: description of two cases by Tamponi, G, Pannocchia, A, Arduino, C, Bazzan, M, Della Dora, N, Schinco, P, Buraglio, M, Eandi, M

“…The biochemistry and functionality of platelets from two related subjects (mother and son) with alpha-2-adrenoceptor-deficient platelets has been evaluated…”
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