Search Results - "Buracchi, Chiara"

Megakaryocytes Contribute to the Bone Marrow‐Matrix Environment by Expressing Fibronectin, Type IV Collagen, and Laminin by Malara, Alessandro, Currao, Manuela, Gruppi, Cristian, Celesti, Giuseppe, Viarengo, Gianluca, Buracchi, Chiara, Laghi, Luigi, Kaplan, David L., Balduini, Alessandra

“…Megakaryocytes associate with the bone marrow vasculature where they convert their cytoplasm into proplatelets that protrude through the vascular endothelium…”
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Functional TRAIL receptors in monocytes and tumor-associated macrophages: A possible targeting pathway in the tumor microenvironment by Liguori, Manuela, Buracchi, Chiara, Pasqualini, Fabio, Bergomas, Francesca, Pesce, Samantha, Sironi, Marina, Grizzi, Fabio, Mantovani, Alberto, Belgiovine, Cristina, Allavena, Paola

“…Despite the accepted dogma that TRAIL kills only tumor cells and spares normal ones, we show in this study that mononuclear phagocytes are susceptible to…”
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Phenotypic profiling of CD34 + cells by advanced flow cytometry improves diagnosis of juvenile myelomonocytic leukemia by Bugarin, Cristina, Antolini, Laura, Buracchi, Chiara, Matarraz, Sergio, Coliva, Tiziana Angela, Van der Velden, Vincent H, Szczepanski, Tomasz, Da Costa, Elaine Sobral, Van der Sluijs, Alita, Novakova, Michaela, Mejstrikova, Ester, Nierkens, Stefan, De Mello, Fabiana Vieira, Fernandez, Paula, Aanei, Carmen, Sędek, Łukasz, Strocchio, Luisa, Masetti, Riccardo, Sainati, Laura, Philippé, Jan, Valsecchi, Maria Grazia, Locatelli, Franco, Van Dongen, Jacques J M, Biondi, Andrea, Orfao, Alberto, Gaipa, Giuseppe

“…Diagnostic criteria for juvenile myelomonocytic leukemia (JMML) are currently well defined, however in some patients diagnosis still remains a challenge. Flow…”
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P1361: SLEEPING BEAUTY PLATFORM FOR ENGINEERING CAR‐CIK CELLS TOWARD A MULTI‐TARGETING STRATEGY IN B‐ALL by Moretti, Alex, Landoni, Beatrice, Melita, Giusi, Buracchi, Chiara, Ponzo, Marianna, Biondi, Andrea, Gaipa, Giuseppe, Magnani, Chiara

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Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6 by Martinez de la Torre, Yeny, Buracchi, Chiara, Borroni, Elena M, Dupor, Jana, Bonecchi, Raffaella, Nebuloni, Manuela, Pasqualini, Fabio, Doni, Andrea, Lauri, Eleonora, Agostinis, Chiara, Bulla, Roberta, Cook, Donald N, Haribabu, Bodduluri, Meroni, Pierluigi, Rukavina, Daniel, Vago, Luca, Tedesco, Francesco, Vecchi, Annunciata, Lira, Sergio A, Locati, Massimo, Mantovani, Alberto

“…Fetal loss in animals and humans is frequently associated with inflammatory conditions. D6 is a promiscuous chemokine receptor with decoy function, expressed…”
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Intestinal Inflammation in Mice Deficient in Tir8, an Inhibitory Member of the IL-1 Receptor Family by Garlanda, Cecilia, Riva, Federica, Polentarutti, Nadia, Buracchi, Chiara, Sironi, Marina, De Bortoli, Maida, Muzio, Marta, Bergottini, Raffaella, Scanziani, Eugenio, Vecchi, Annunciata, Hirsch, Emilio, Mantovani, Alberto, Dinarello, Charles A.

“…TIR8, also known as single lg IL-1-related receptor, is a member of the IL-1 receptor/Toll-like receptor (TLR) superfamily, which acts as an intracellular…”
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Damping Excessive Inflammation and Tissue Damage in Mycobacterium tuberculosis Infection by Toll IL-1 Receptor 8/Single Ig IL-1-Related Receptor, a Negative Regulator of IL-1/TLR Signaling by Garlanda, Cecilia, Di Liberto, Diana, Vecchi, Annunciata, La Manna, Marco P, Buracchi, Chiara, Caccamo, Nadia, Salerno, Alfredo, Dieli, Francesco, Mantovani, Alberto

“…Toll IL-1R 8/single Ig IL-1-related receptor (TIR8/SIGIRR) is a member of the IL-1R family, expressed by epithelial tissues and immature dendritic cells, and…”
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Therapeutic afucosylated monoclonal antibody and bispecific T-cell engagers for T-cell acute lymphoblastic leukemia by Caracciolo, Daniele, Riillo, Caterina, Ballerini, Andrea, Gaipa, Giuseppe, Lhermitte, Ludovic, Rossi, Marco, Botta, Cirino, Duroyon, Eugénie, Grillone, Katia, Gallo Cantafio, Maria Eugenia, Buracchi, Chiara, Alampi, Greta, Gulino, Alessandro, Belmonte, Beatrice, Conforti, Francesco, Golino, Gaetanina, Juli, Giada, Altomare, Emanuela, Polerà, Nicoletta, Scionti, Francesca, Arbitrio, Mariamena, Iannone, Michelangelo, Martino, Massimo, Correale, Pierpaolo, Talarico, Gabriella, Ghelli Luserna di Rorà, Andrea, Ferrari, Anna, Concolino, Daniela, Sestito, Simona, Pensabene, Licia, Giordano, Antonio, Hildinger, Markus, Di Martino, Maria Teresa, Martinelli, Giovanni, Tripodo, Claudio, Asnafi, Vahid, Biondi, Andrea, Tagliaferri, Pierosandro, Tassone, Pierfrancesco

“…BackgroundT-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease with a poor cure rate for relapsed/resistant patients. Due to the lack of T-cell…”
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Increased inflammation in mice deficient for the chemokine decoy receptor D6 by de la Torre, Yeny Martinez, Locati, Massimo, Buracchi, Chiara, Dupor, Jana, Cook, Donald N., Bonecchi, Raffaella, Nebuloni, Manuela, Rukavina, Daniel, Vago, Luca, Vecchi, Annunciata, Lira, Sergio A., Mantovani, Alberto

“…Chemokines are chemotactic cytokines with a key role in the control of cell trafficking and positioning under homeostatic and inflammatory conditions. D6 is a…”
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Targeted Gene Correction in Osteopetrotic-Induced Pluripotent Stem Cells for the Generation of Functional Osteoclasts by Neri, Tui, Muggeo, Sharon, Paulis, Marianna, Caldana, Maria Elena, Crisafulli, Laura, Strina, Dario, Focarelli, Maria Luisa, Faggioli, Francesca, Recordati, Camilla, Scaramuzza, Samantha, Scanziani, Eugenio, Mantero, Stefano, Buracchi, Chiara, Sobacchi, Cristina, Lombardo, Angelo, Naldini, Luigi, Vezzoni, Paolo, Villa, Anna, Ficara, Francesca

“…Autosomal recessive osteopetrosis is a human bone disease mainly caused by TCIRG1 gene mutations that prevent osteoclasts resorbing activity, recapitulated by…”
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The CCL3 Family of Chemokines and Innate Immunity Cooperate In Vivo in the Eradication of an Established Lymphoma Xenograft by Rituximab by Cittera, Elena, Leidi, Marzia, Buracchi, Chiara, Pasqualini, Fabio, Sozzani, Silvano, Vecchi, Annunciata, Waterfield, J. Douglas, Introna, Martino, Golay, Josee

“…The therapeutic mAb rituximab induced the expression of the CCL3 and CCL4 chemokines in the human lymphoma line BJAB following binding to the CD20 Ag…”
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Differential Effects of Immunosuppressive Drugs on Chemokine Receptor CCR7 in Human Monocyte-Derived Dendritic Cells: Selective Upregulation by Rapamycin by Sordi, Valeria, Bianchi, Giancarlo, Buracchi, Chiara, Mercalli, Alessia, Marchesi, Federica, D'Amico, Giovanna, Yang, Cui-Hong, Luini, Walter, Vecchi, Annunciata, Mantovani, Alberto, Allavena, Paola, Piemonti, Lorenzo

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Sleeping Beauty-engineered CAR T cells achieve antileukemic activity without severe toxicities by Magnani, Chiara F, Gaipa, Giuseppe, Lussana, Federico, Belotti, Daniela, Gritti, Giuseppe, Napolitano, Sara, Matera, Giada, Cabiati, Benedetta, Buracchi, Chiara, Borleri, Gianmaria, Fazio, Grazia, Zaninelli, Silvia, Tettamanti, Sarah, Cesana, Stefania, Colombo, Valentina, Quaroni, Michele, Cazzaniga, Giovanni, Rovelli, Attilio, Biagi, Ettore, Galimberti, Stefania, Calabria, Andrea, Benedicenti, Fabrizio, Montini, Eugenio, Ferrari, Silvia, Introna, Martino, Balduzzi, Adriana, Valsecchi, Maria Grazia, Dastoli, Giuseppe, Rambaldi, Alessandro, Biondi, Andrea

“…BACKGROUNDChimeric antigen receptor (CAR) T cell immunotherapy has resulted in complete remission (CR) and durable response in highly refractory patients…”
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Standardized flow cytometry for highly sensitive MRD measurements in B-cell acute lymphoblastic leukemia by Theunissen, Prisca, Mejstrikova, Ester, Sedek, Lukasz, van der Sluijs-Gelling, Alita J., Gaipa, Giuseppe, Bartels, Marius, Sobral da Costa, Elaine, Kotrová, Michaela, Novakova, Michaela, Sonneveld, Edwin, Buracchi, Chiara, Bonaccorso, Paola, Oliveira, Elen, te Marvelde, Jeroen G., Szczepanski, Tomasz, Lhermitte, Ludovic, Hrusak, Ondrej, Lecrevisse, Quentin, Grigore, Georgiana Emilia, Froňková, Eva, Trka, Jan, Brüggemann, Monika, Orfao, Alberto, van Dongen, Jacques J.M., van der Velden, Vincent H.J.

“…A fully-standardized EuroFlow 8–color antibody panel and laboratory procedure was stepwise designed to measure minimal residual disease (MRD) in B-cell…”
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Diverse mechanisms of leukemogenesis associated with PAX5 germline mutation by Bettini, Laura Rachele, Fazio, Grazia, Saitta, Claudia, Piazza, Rocco, Palamini, Sonia, Buracchi, Chiara, Rebellato, Stefano, Santoro, Nicola, Simone, Cristiano, Biondi, Andrea, Cazzaniga, Giovanni

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Role of Microenvironment in Influencing the Activity of CD19 CAR T Cells in B-Cell Precursor Acute Lymphoblastic Leukemia (B-ALL) by Ponzo, Marianna, Drufuca, Lorenzo, Buracchi, Chiara, Nucera, Silvia, Bugarin, Cristina, Rossetti, Grazisa, Bonnal, Raoul, Rambaldi, Benedetta, Biondi, Andrea, Gaipa, Giuseppe, Pagani, Massimiliano, Magnani, Chiara Francesca

“…Background: As a therapy based on immune cells, CAR T cells treatment elicits an acute response involving both innate and adaptive immunity which is followed…”
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First Description of a Frameshift PAX5 Germline Variant in Two Siblings with B-Cell Precursor Acute Lymphoblastic Leukemia by Bettini, Laura Rachele, Fazio, Grazia, Saitta, Claudia, Palamini, Sonia, Buracchi, Chiara, Rebellato, Stefano, Santoro, Nicola, Simone, Cristiano, Biondi, Andrea, Cazzaniga, Giovanni

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Flow cytometry for minimal residual disease testing in acute leukemia: opportunities and challenges by Gaipa, Giuseppe, Buracchi, Chiara, Biondi, A

“…Flow cytometric quantification of minimal residual disease (MRD) in acute leukemia (AL) represents an indispensable tool to guide modern therapeutic protocols…”
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Targeting CD33 in Chemoresistant AML Patient-Derived Xenografts by CAR-CIK Cells Modified with an Improved SB Transposon System by Rotiroti, Maria Caterina, Buracchi, Chiara, Arcangeli, Silvia, Galimberti, Stefania, Valsecchi, Maria Grazia, Perriello, Vincenzo Maria, Rasko, Tamas, Alberti, Gaia, Magnani, Chiara Francesca, Cappuzzello, Claudia, Lundberg, Felix, Pande, Amit, Dastoli, Giuseppe, Introna, Martino, Serafini, Marta, Biagi, Ettore, Izsvák, Zsuzsanna, Biondi, Andrea, Tettamanti, Sarah

“…The successful implementation of chimeric antigen receptor (CAR)-T cell therapy in the clinical context of B cell malignancies has paved the way for further…”
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Single‐cell profiling of pediatric T‐cell acute lymphoblastic leukemia: Impact of PTEN exon 7 mutation on PI3K/Akt and JAK–STAT signaling pathways by Bonaccorso, Paola, Bugarin, Cristina, Buracchi, Chiara, Fazio, Grazia, Biondi, Andrea, Lo Nigro, Luca, Gaipa, Giuseppe

“…Background The PI3K/Akt/mTOR (PI3K) signaling pathway has a crucial role in T‐cell acute lymphoblastic leukemias (T‐ALLs). Although loss‐of‐function of…”
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